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Harry Demopoulos
Harry B. Demopoulos is a researcher in the medical aspects of free radicals, especially in the areas of ischaemic injury, the toxicity of anticancer drugs, and in spinal cord injury. He has also been a film actor and is currently a member of the Board of Trustees of the Doris Duke Charitable Foundation. Free radical research Ischaemic injury (injury to cells due to oxygen deprivation) is an important cause of morbidity and mortality in humans. For example, most deaths in stroke and heart attack are secondary to ischaemic injury, a consequence of the ischemic cascade. Thus, much research has been done into the causes and treatment of ischaemic injury. One are of this research involves the essential role of free radicals (reactive oxygen species and the like) as modulators of ischaemic injury. This has resulted in therapeutic advances, such as the radical-scavenging neuroprotective agent NXY-059, which was under development for the treatment of stroke. Demopoulos and his coworker ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Free Radicals
In chemistry, a radical, also known as a free radical, is an atom, molecule, or ion that has at least one unpaired valence electron. With some exceptions, these unpaired electrons make radicals highly chemically reactive. Many radicals spontaneously dimerize. Most organic radicals have short lifetimes. A notable example of a radical is the hydroxyl radical (HO·), a molecule that has one unpaired electron on the oxygen atom. Two other examples are triplet oxygen and triplet carbene (꞉) which have two unpaired electrons. Radicals may be generated in a number of ways, but typical methods involve redox reactions. Ionizing radiation, heat, electrical discharges, and electrolysis are known to produce radicals. Radicals are intermediates in many chemical reactions, more so than is apparent from the balanced equations. Radicals are important in combustion, atmospheric chemistry, polymerization, plasma chemistry, biochemistry, and many other chemical processes. A majori ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clint Eastwood
Clinton Eastwood Jr. (born May 31, 1930) is an American actor and film director. After achieving success in the Western TV series '' Rawhide'', he rose to international fame with his role as the " Man with No Name" in Sergio Leone's "'' Dollars Trilogy''" of Spaghetti Westerns during the mid-1960s and as antihero cop Harry Callahan in the five '' Dirty Harry'' films throughout the 1970s and 1980s. These roles, among others, have made Eastwood an enduring cultural icon of masculinity. Elected in 1986, Eastwood served for two years as the mayor of Carmel-by-the-Sea, California. An Academy Award nominee for Best Actor, Eastwood won Best Director and Best Picture for his Western film '' Unforgiven'' (1992) and his sports drama '' Million Dollar Baby'' (2004). His greatest commercial successes are the adventure comedy '' Every Which Way but Loose'' (1978) and its action comedy sequel '' Any Which Way You Can'' (1980). Other popular Eastwood films include the Westerns ''H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Medical Researchers
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Affidavit
An ( ; Medieval Latin for "he has declared under oath") is a written statement voluntarily made by an ''affiant'' or '' deponent'' under an oath or affirmation which is administered by a person who is authorized to do so by law. Such a statement is witnessed as to the authenticity of the affiant's signature by a taker of oaths, such as a notary public or commissioner of oaths. An affidavit is a type of verified statement or showing, or in other words, it contains a verification, which means that it is made under oath on penalty of perjury, and this serves as evidence for its veracity and is required in court proceedings. Definition An affidavit is typically defined as a written declaration or statement that is sworn or affirmed before a person who has authority to administer an oath. There is no general defined form for an affidavit, although for some proceedings an affidavit must satisfy legal or statutory requirements in order to be considered. An affidavit may include, * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bernard Lafferty
Bernard Lafferty (14 April 1945 – 4 November 1996) was an Irish butler and heir to American tobacco heiress and philanthropist, Doris Duke. Duke hired Lafferty in 1987 and named him the executor of her $1.2 billion estate six months prior to her death in October 1993. Their unorthodox relationship sparked controversy and speculation, although no charges were ever filed against Lafferty regarding her death. Early life Bernard Lafferty was born on April 14, 1945, in Creeslough, County Donegal, Ireland. He was the only child of Edward Lafferty (1901-1964) and Angela McCalliog (1915-1965). He was a first cousin of Scottish former footballer Jim McCalliog. He moved to Glasgow, Scotland, with his mother shortly after his father's death in September 1964. Lafferty was orphaned at 20 years old when his mother was hit by a motorcycle the following August. Career and Doris Duke Lafferty emigrated to the United States to live with his aunt in Philadelphia around 1980. Lafferty became ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doris Duke
Doris Duke (November 22, 1912 – October 28, 1993) was an American billionaire tobacco heiress, philanthropist, art collector, horticulturalist, and socialite. She was often called "the richest girl in the world". Her great wealth, luxurious lifestyle, and love life attracted significant press coverage, both during her life and after her death. Duke's passions varied wildly. Briefly a news correspondent in the 1940s, she also played jazz piano and learned to surf competitively. At her father's estate in Hillsborough Township, New Jersey, she created one of America's largest indoor botanical displays. She was also active in preserving more than 80 historic buildings in Newport, Rhode Island. Duke was close friends with former First Lady Jacqueline Kennedy Onassis, and in 1968, when Duke created the Newport Restoration Foundation, Kennedy Onassis was appointed the vice president and championed the foundation. Her philanthropic work in AIDS research, medicine, and child welfa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Dead Pool
''The Dead Pool'' is a 1988 American neo-noir vigilante action thriller film directed by Buddy Van Horn, written by Steve Sharon, and starring Clint Eastwood as Inspector "Dirty" Harry Callahan. It is the fifth and final film in the ''Dirty Harry'' film series and is set in San Francisco, California. The story concerns the manipulation of a dead pool game by a serial killer, whose efforts are confronted by the hardened detective Callahan. It co-stars Liam Neeson (in his first action film) and Patricia Clarkson, with Jim Carrey in his first dramatic role. It is the only film in the series not to feature Albert Popwell, an actor who had played a different character in each of the previous four films. At 91 minutes, it is the shortest of the five ''Dirty Harry'' films. Like those films, ''The Dead Pool'' is notable for coining catchphrases uttered by Clint Eastwood's gun-wielding character, one of which is: "Opinions are like assholes; everybody has one". Plot Inspector ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sylvester Stallone
Sylvester Enzio Stallone (; born Michael Sylvester Gardenzio Stallone, ) is an American actor and filmmaker. After his beginnings as a struggling actor for a number of years upon arriving to New York City in 1969 and later Hollywood in 1974, he won his first critical acclaim as an actor for his co-starring role as Stanley Rosiello in ''The Lords of Flatbush''. Stallone subsequently found gradual work as an extra or side character in films with a sizable budget until he achieved his greatest critical and commercial success as an actor and screenwriter, starting in 1976 with his role as boxer Rocky Balboa, in the first film of the successful ''Rocky'' series (1976–present), for which he also wrote the screenplays. In the films, Rocky is portrayed as an underdog boxer who fights numerous brutal opponents, and wins the world heavyweight championship twice. In 1977, Stallone was the third actor in cinema to be nominated for two Academy Awards for Best Original Screenplay and B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cobra (1986 Film)
''Cobra'' is a 1986 American action film directed by George P. Cosmatos and written by Sylvester Stallone, who also starred in the title role. The film co-stars Reni Santoni, Brigitte Nielsen and Andrew Robinson. It is the first film in which Brian Thompson plays a prominent role. The film was loosely based on the novel ''Fair Game'' by Paula Gosling, which was later filmed under that title in 1995. However, Stallone's screenplay was originally conceived from ideas he had during pre-production of '' Beverly Hills Cop'', whose screenplay he heavily revised. He had wanted to make ''Beverly Hills Cop'' a less comedic and more action-oriented film, which the studio rejected as being far too expensive. When he left that project, Eddie Murphy was brought in to play the lead role. The film received generally negative reviews, with much criticism focused on the overuse of genre tropes and excessive violence. It debuted at the number one spot on the U.S. box office, and earned $49 mil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
City Heat
''City Heat'' is a 1984 American buddy-crime-comedy film starring Clint Eastwood and Burt Reynolds, written by Blake Edwards, and directed by Richard Benjamin. The film was released in North America in December 1984. The pairing of Eastwood and Reynolds was expected to be a major box-office hit, but the film earned a disappointing $38.3 million against a $25 million budget. Plot In Kansas City, 1933, police lieutenant Speer goes to a diner for coffee. Two men arrive, looking for a former cop turned private eye named Mike Murphy. Speer and Murphy were good friends until the latter left the force. The men pounce on Murphy the minute he arrives. Speer ignores them until a goon causes him to spill his coffee. Both goons are thrown through the front door. Murphy sarcastically thanks Speer for saving his life. The two rivals have eyes for Murphy's secretary Addy. She loves both and proves it when, after tenderly kissing Murphy goodbye, she goes on a date with Speer. Murphy has a new ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sudden Impact
''Sudden Impact'' is a 1983 American vigilante action thriller film, the fourth in the ''Dirty Harry'' series, directed, produced by and starring Clint Eastwood (making it the only ''Dirty Harry'' film to be directed by Eastwood himself) and co-starring Sondra Locke. The film tells the story of a gang rape victim (Locke) who decides to seek revenge on the rapists ten years after the attack by killing them one by one. Inspector Callahan (Eastwood), famous for his unconventional and often brutal crime-fighting tactics, is tasked with tracking down the serial killer. The film is notable for the catchphrase "Go ahead, make my day", written by John Milius and uttered by Clint Eastwood's gun-wielding character in the beginning of the film as he stares down an armed robber who is holding a hostage. Plot In 1973, artist Jennifer Spencer and her sister, Beth, are gang-raped. The attack leaves Beth in a catatonic state. Ten years later, an enraged Spencer seeks revenge and kills Georg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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