|
Human Protein Atlas
The Human Protein Atlas (HPA) is a Swedish-based program started in 2003 with the aim to map all the human proteins in cells, tissues and organs using integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome. In June 2023, version 23 was launched where a new Interaction section was introduced containing human protein-protein interaction networks for more than 11,000 genes that will add new aspects in terms of protein function. The resource now includes twelve separate sections with complementary information about all human proteins. All data has been updated on the approximately 5 million individual web pages. The Human Protein Atlas program has already contributed to several thousands of publications in the field of human ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Human Protein Atlas
The Human Protein Atlas (HPA) is a Swedish-based program started in 2003 with the aim to map all the human proteins in cells, tissues and organs using integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome. In June 2023, version 23 was launched where a new Interaction section was introduced containing human protein-protein interaction networks for more than 11,000 genes that will add new aspects in terms of protein function. The resource now includes twelve separate sections with complementary information about all human proteins. All data has been updated on the approximately 5 million individual web pages. The Human Protein Atlas program has already contributed to several thousands of publications in the field of human ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systems Biology
Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionist, reductionism) to biological research. This multifaceted research domain necessitates the collaborative efforts of chemists, biologists, mathematicians, physicists, and engineers to decipher the biology of intricate living systems by merging various quantitative molecular measurements with carefully constructed mathematical models. It represents a comprehensive method for comprehending the complex relationships within biological systems. In contrast to conventional biological studies that typically center on isolated elements, systems biology seeks to combine different biological data to create models that illustrate and elucidate the dynamic interactions with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Databases
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residues i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CC BY-SA Icon
CC, cc, or C-C may refer to: Arts, entertainment, and media Fictional characters * C.C. (''Code Geass''), a character in the ''Code Geass'' anime series, pronounced "C-two" * C.C. Babcock, a character in the American sitcom ''The Nanny'' * Comedy Chimp, a character in ''Sonic Boom'', called "CC" by Doctor Eggman Gaming * ''Command & Conquer'' (''C&C''), a series of real-time strategy games and the first game in the series * Crowd control (video gaming), the ability to limit the number of mobs actively fighting during an encounter Other arts, music, entertainment, and media * Cannibal Corpse, an American death metal band. * CC Media Holdings, the former name of iHeartMedia * Closed captioning, a process of displaying text on a visual display, such as a TV screen * Comedy Central, an American television network (URL is cc.com) * '' Creative Camera'', defunct British photography magazine * "Cc", a song by Ecco2K from his album '' E'' Brands and enterprises Food and drink * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Cancer Genome Atlas
The Cancer Genome Atlas (TCGA) is a project to catalogue the genomic alterations responsible for cancer using genome sequencing and bioinformatics. The overarching goal was to apply high-throughput genome analysis techniques to improve the ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of the disease. TCGA was supervised by the National Cancer Institute's Center for Cancer Genomics and the National Human Genome Research Institute funded by the US government. A three-year pilot project, begun in 2006, focused on characterization of three types of human cancers: glioblastoma multiforme, lung squamous carcinoma, and ovarian serous adenocarcinoma. In 2009, it expanded into phase II, which planned to complete the genomic characterization and sequence analysis of 20–25 different tumor types by 2014. Ultimately, TCGA surpassed that goal, characterizing 33 cancer types including 10 rare cancers. The project initially set out to co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Expression Atlas
The Expression Atlas is a database maintained by the European Bioinformatics Institute that provides information on gene expression patterns from RNA-Seq and Microarray studies, and protein expression from Proteomics studies. The Expression Atlas allows searches by gene, splice variant, protein attribute, disease, treatment or organism part (cell types/tissues). Individual genes or gene sets can be searched for. All datasets in Expression Atlas have its metadata manually curated and its data analysed through standardised analysis pipelines. There are two components to the Expression Atlas, the Baseline Atlas and the Differential Atlas: Baseline Atlas The Baseline Atlas provides information about which gene products are present (and at what abundance) under "normal" conditions. This component of the Expression Atlas consists of RNA-seq experiments from ArrayExpress repositories. It aims to answer questions such as: * Which genes are specifically expressed in kidney? * What is t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mathias Uhlén
Mathias Uhlén (born May 1954) is a Swedish scientist and Professor of Microbiology at Royal Institute of Technology (KTH), Stockholm. After a post-doc period at the EMBL in Heidelberg, Germany, he became professor in microbiology at KTH in 1988. His research is focused on protein science, antibody engineering and precision medicine and range from basic research in human and microbial biology to more applied research, including clinical applications. He is member of several academies and societies, including Royal Swedish Academy of Science (KVA), National Academy of Engineering (NAE) and the Swedish Academy of Engineering Science (IVA). Dr Uhlen was the Founding Director of the national infrastructure Science for Life Laboratory ( SciLifeLab) from 2010 to 2015. Research His group was the first to describe a number of innovations in science including: Protein engineering This broad concept of Affinity-based protein engineering was developed to use specific binding (affin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Institute Of Technology
KTH Royal Institute of Technology (), abbreviated KTH, is a public research university in Stockholm, Sweden. KTH conducts research and education in engineering and technology and is Sweden's largest technical university. Since 2018, KTH consists of five schools with four campuses in and around Stockholm. KTH was established in 1827 as the ''Teknologiska institutet'' (Institute of Technology) and had its roots in the ''Mekaniska skolan'' (School of Mechanics) that was established in 1798 in Stockholm. But the origin of KTH dates back to the predecessor of the ''Mekaniska skolan'', the ''Laboratorium mechanicum'', which was established in 1697 by the Swedish scientist and innovator Christopher Polhem. The ''Laboratorium mechanicum'' combined education technology, a laboratory, and an exhibition space for innovations. In 1877, KTH received its current name, ''Kungliga Tekniska högskolan'' (KTH Royal Institute of Technology). The Swedish king, His Majesty Carl XVI Gustaf, is the pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunohistochemistry
Immunohistochemistry is a form of immunostaining. It involves the process of selectively identifying antigens in cells and tissue, by exploiting the principle of Antibody, antibodies binding specifically to antigens in biological tissues. Albert Coons, Albert Hewett Coons, Ernst Berliner, Ernest Berliner, Norman Jones and Hugh J Creech was the first to develop immunofluorescence in 1941. This led to the later development of immunohistochemistry. Immunohistochemical staining is widely used in the diagnosis of abnormal cells such as those found in cancerous tumors. In some cancer cells certain tumor antigens are expressed which make it possible to detect. Immunohistochemistry is also widely used in basic research, to understand the distribution and localization of biomarkers and differentially expressed proteins in different parts of a biological tissue. Sample preparation Immunohistochemistry can be performed on tissue that has been fixed and embedded in Paraffin wax, paraffin, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Knut And Alice Wallenberg Foundation
Knut and Alice Wallenberg Foundation (KAW) () is a Swedish public and private foundation formed in 1917 by Knut Agathon Wallenberg and his wife Alice Wallenberg. It was created to support research in the natural sciences, technology and medicine by awarding long-term grants to basic research of the highest international class. Governance From its start in 1917 to 1971 the board members of the Foundation were mostly from the Wallenberg family. In 1971 a Council of Principals was established which changed the membership pattern, and the academics began to serve as board members of the KAW. Then politicians from the Centre Party were also assigned to the board, including , Anders Dahlgren, and Thorbjörn Fälldin. Funding Since its establishment it has approved funding of just over SEK 27.2 billion to Swedish research and education. Almost SEK 14.5 billion of this was awarded between 2008 and 2018. The funding allocated annually in recent years of almost SEK 2 billion has given ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ELIXIR
An elixir is a sweet liquid used for medical purposes, to be taken orally and intended to cure one's illness. When used as a dosage form, pharmaceutical preparation, an elixir contains at least one active ingredient designed to be taken orally. Etymology The word was introduced in late Middle English, through Medieval Latin, Latin from the Arabic Language, Arabic (), which in turn is the Arabization of the Ancient Greek () (from () ). For centuries, ''elixir'' primarily meant an ingredient used in alchemy, either referring to a liquid which purportedly converts lead to gold, or a substance or liquid which is believed to cure all ills and Elixir of immortality, give eternal life. Types Non-medicated elixirs These are used as solvents or vehicles for the preparation of medicated elixirs. Active ingredients are dissolved in a 15–50% by volume solution of Ethanol, ethyl alcohol: *aromatic elixirs (United States Pharmacopeia, USP) *isoalcoholic elixirs (Formulary (pharm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteome
A proteome is the entire set of proteins that is, or can be, expressed by a genome, cell, tissue, or organism at a certain time. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. Proteomics is the study of the proteome. Types of proteomes While proteome generally refers to the proteome of an organism, multicellular organisms may have very different proteomes in different cells, hence it is important to distinguish proteomes in cells and organisms. A cellular proteome is the collection of proteins found in a particular cell (biology), cell type under a particular set of environmental conditions such as exposure to hormone, hormone stimulation. It can also be useful to consider an organism's complete proteome, which can be conceptualized as the complete set of proteins from all of the various cellular proteomes. This is very roughly the protein equivalent of the genome. The term ''proteome'' has also been used to r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
