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Harry Demopoulos
Harry B. Demopoulos was an American researcher in the medical aspects of free radicals, especially in the areas of ischaemic injury, the toxicity of anticancer drugs, and in spinal cord injury. He was also a film actor, appearing in Clint Eastwood films. Free radical research Ischaemic injury (injury to cells due to oxygen deprivation) is an important cause of morbidity and mortality in humans. For example, most deaths in stroke and heart attack are secondary to ischaemic injury, a consequence of the ischemic cascade. Thus, much research has been done into the causes and treatment of ischaemic injury. One are of this research involves the essential role of free radicals (reactive oxygen species and the like) as modulators of ischaemic injury. This has resulted in therapeutic advances, such as the radical-scavenging neuroprotective agent NXY-059, which was under development for the treatment of stroke. Demopoulos and his coworkers were active in this research. The opening sentence ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Free Radicals
In chemistry, a radical, also known as a free radical, is an atom, molecule, or ion that has at least one unpaired electron, unpaired valence electron. With some exceptions, these unpaired electrons make radicals highly chemical reaction, chemically reactive. Many radicals spontaneously dimer (chemistry), dimerize. Most organic radicals have short lifetimes. A notable example of a radical is the hydroxyl radical (HO·), a molecule that has one unpaired electron on the oxygen atom. Two other examples are triplet oxygen and methylene radical, triplet carbene (꞉) which have two unpaired electrons. Radicals may be generated in a number of ways, but typical methods involve redox reactions. Ionizing radiation, heat, electrical discharges, and electrolysis are known to produce radicals. Radicals are intermediates in many chemical reactions, more so than is apparent from the balanced equations. Radicals are important in combustion, atmospheric chemistry, polymerization, Plasma (phy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bernard Lafferty
Bernard Lafferty (14 April 1945 – 4 November 1996) was an Irish butler and heir to American tobacco heiress and philanthropist, Doris Duke. Duke hired Lafferty in 1987 and named him the executor of her $1.2 billion estate six months prior to her death in October 1993. Their unorthodox relationship sparked controversy and speculation, although no charges were ever filed against Lafferty regarding her death. Early life Bernard Lafferty was born on April 14, 1945, in Creeslough, County Donegal, Ireland. He was the only child of Edward Lafferty (1901–1964) and Angela McCalliog (1915–1965). He was a first cousin of Scottish former footballer Jim McCalliog. He moved to Glasgow, Scotland, with his mother shortly after his father's death in September 1964. One year later, Lafferty was orphaned at 20 years old when his mother was hit by a motorcycle the following August. Career and Doris Duke Lafferty emigrated to the United States to live with his aunt in Philadelphia around 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Male Film Actors
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports tea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2016 Deaths
This is a list of lists of deaths of notable people, organized by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked below. 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 Earlier years ''Deaths in years earlier than this can usually be found in the main articles of the years.'' See also * Lists of deaths by day * Deaths by year (category) {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Dead Pool
''The Dead Pool'' is a 1988 American action-thriller film directed by Buddy Van Horn, written by Steve Sharon, and starring Clint Eastwood as Inspector "Dirty" Harry Callahan. It is the fifth and final film in the ''Dirty Harry'' film series and is set in San Francisco, California. The story concerns the manipulation of a dead pool game by a serial killer, whose efforts are confronted by the hardened detective Callahan. It co-stars Liam Neeson (in his first action film) and Patricia Clarkson, with Jim Carrey in his first dramatic role. The film also features an appearance by future Mario voice actor Charles Martinet. It is the only film in the series not to feature Albert Popwell, an actor who had played a different character in each of the previous four films, as well as the only one to be recorded in Dolby Stereo. At 91 minutes, it is the shortest of the five ''Dirty Harry'' films. Like those films, ''The Dead Pool'' is notable for coining catchphrases uttered by Clint ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sylvester Stallone
Sylvester Gardenzio "Sly" Stallone (; born July 6, 1946) is an American actor and filmmaker. In a Sylvester Stallone filmography, film career spanning more than fifty years, Stallone has received List of awards and nominations received by Sylvester Stallone, numerous accolades, including a Golden Globe Awards, Golden Globe Award and a Critics' Choice Movie Awards, Critics' Choice Award, as well as nominations for three Academy Awards and two British Academy Film Awards, BAFTA Awards. Stallone is one of only two actors in history (alongside Harrison Ford) to have starred in a box-office No.1 film across six consecutive decades. Films in which he has appeared in have grossed over $7.5 billion worldwide. Struggling as an actor for a number of years upon moving to New York City in 1969, Stallone found gradual work in films such as ''The Lords of Flatbush'' (1974). He achieved his greatest critical and commercial success starting in 1976 with his iconic role as boxer Rocky Balboa i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cobra (1986 Film)
''Cobra'' is a 1986 American action film directed by George P. Cosmatos and written by Sylvester Stallone, who stars in the titular role. The film, loosely based on the 1974 novel ''A Running Duck'' by Paula Gosling (later published as ''Fair Game'' and filmed under that title in 1995), co-stars Reni Santoni, Brigitte Nielsen and Andrew Robinson. ''Cobra'' follows Los Angeles police Lt. Marion "Cobra" Cobretti, who investigates a string of violent crimes and also protects a witness targeted by the perpetrators. ''Cobra'' is the final film which featured the collaboration between Stallone and Nielsen after ''Rocky IV'' (1985) and until ''Creed II'' (2018), and the only film the pair are both featured in while married to one another in real life, before their divorce a year later. The script was largely inspired by Stallone's original script for ''Beverly Hills Cop'' (1984). ''Cobra'' was released to generally negative reviews with criticism on its excessive violence and ove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
City Heat
''City Heat'' is a 1984 American buddy- crime comedy film starring Clint Eastwood and Burt Reynolds, written by Blake Edwards and directed by Richard Benjamin. The film was released in North America in December 1984. The pairing of Eastwood and Reynolds was expected to be a major box-office hit, but the film earned a disappointing $38.3 million against a $25 million budget, making it a net money loser after production, promotion and distribution costs. Plot In Kansas City, 1933, police lieutenant Speer goes to a diner for coffee. Two men arrive, looking for a former cop turned private eye named Mike Murphy. Speer and Murphy were good friends until the latter left the force. The men pounce on Murphy the minute he arrives. Speer ignores them until a goon causes him to spill his coffee. Both goons are thrown through the front door. Murphy sarcastically thanks Speer for saving his life. The two rivals have eyes for Murphy's secretary Addy. She loves both and proves it when, after ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sudden Impact
''Sudden Impact'' is a 1983 American action-thriller film, the fourth in the ''Dirty Harry'' series, directed, produced by, and starring Clint Eastwood (making it the only ''Dirty Harry'' film to be directed by Eastwood himself) and co-starring Sondra Locke. The film tells the story of a gang-rape victim (Locke) who decides to seek revenge on her rapists 10 years after the attack by killing them one by one. Inspector Callahan (Eastwood), famous for his unconventional and often brutal crime-fighting tactics, is tasked with tracking down the serial killer. The film is notable for the catchphrase " Go ahead, make my day", written by John Milius and uttered by Clint Eastwood's gun-wielding character in the beginning of the film as he stares down an armed robber who is holding a hostage. This is the last ''Dirty Harry'' film to feature Albert Popwell. Plot In 1973, artist Jennifer Spencer and her sister, Beth, are gang raped; the attack leaves Beth in a catatonic state. Ten years ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Board Of Trustees
A board of directors is a governing body that supervises the activities of a business, a nonprofit organization, or a government agency. The powers, duties, and responsibilities of a board of directors are determined by government regulations (including the jurisdiction's corporate law) and the organization's own constitution and by-laws. These authorities may specify the number of members of the board, how they are to be chosen, and how often they are to meet. In an organization with voting members, the board is accountable to, and may be subordinate to, the organization's full membership, which usually elect the members of the board. In a stock corporation, non-executive directors are elected by the shareholders, and the board has ultimate responsibility for the management of the corporation. In nations with codetermination (such as Germany and Sweden), the workers of a corporation elect a set fraction of the board's members. The board of directors appoints the chief e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doris Duke
Doris Duke (November 22, 1912 – October 28, 1993) was an American billionaire tobacco heiress, philanthropist, and socialite. She was often called "the richest girl in the world". Her great wealth, luxurious lifestyle, and love life attracted significant press coverage, both during her life and after her death. Duke's passions varied wildly. Briefly a news correspondent in the 1940s, she also played jazz piano and learned to surf competitively. At her father's estate in Hillsborough Township, New Jersey, she created one of the largest indoor botanical displays in the United States. She was also active in preserving more than 80 historic buildings in Newport, Rhode Island. Duke was close friends with former First Lady Jacqueline Kennedy Onassis. In 1968, Duke created the Newport Restoration Foundation, and Kennedy Onassis was appointed the vice president and championed the foundation. Her philanthropic work in AIDS research, medicine, and child welfare continued into her ol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
