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Fox Chase Cancer Center
Fox Chase Cancer Center is a National Cancer Institute-designated Comprehensive Cancer Center research facility and hospital located in the Fox Chase section of Philadelphia, Pennsylvania, United States. The main facilities of the center are located on property adjoining Burholme Park. The center is part of the Temple University Health System (TUHS) and specializes in the treatment and prevention of cancer. History The center was formed in 1974 by the merger of the American Oncologic Hospital, which was founded in 1904 as the first cancer hospital in the United States, and the Institute for Cancer Research, founded in 1927. In 1967 a large wing of the hospital was constructed based on a design by Vincent G. Kling using steep slopes of poured concrete and roof tiles by Ludowici. In 1995, Fox Chase also became a founding member of the National Comprehensive Cancer Network, an alliance of 21 of the nation's leading academic cancer centers. The center was an independent, no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Temple University Health System
Temple Health also known as Temple University Health System is a non-profit academic healthcare network based in the Philadelphia, Pennsylvania, United States. The healthcare network serves Pennsylvania and its flagship hospital is Temple University Hospital, a safety net hospital, located in Philadelphia. Research activities are carried out by the affiliates of Temple University Health System and the Lewis Katz School of Medicine at Temple University. Locations Temple Health operates the following hospitals: *Temple University Hospital *Temple University Hospital – Jeanes Campus *Temple University Hospital – Episcopal Campus *Temple University Hospital – Northeastern Campus *Temple Health - Fox Chase Cancer Center *Temple Health - Chestnut Hill Hospital History Temple Health began in 1891 as a way for the poor to get needed medical care. Samaritan Hospital was founded by Grace Baptist of Philadelphia and its leader Russell Conwell. In the hospital’s first year, it was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Comprehensive Cancer Network
The National Comprehensive Cancer Network (NCCN) is an alliance of 33 cancer centers in the United States, most of which are designated by the National Cancer Institute (one of the U.S. National Institutes of Health) as comprehensive cancer centers. It is a non-profit organization with offices in Plymouth Meeting, Pennsylvania. John W. Sweetenham, MD, FRCP, FACP, FASCO, from UT Southwestern Simmons Comprehensive Cancer Center, is chairman of the NCCN Board of Directors. It publishes a peer-reviewed medical journal called ''Journal of the National Comprehensive Cancer Network''. History The NCCN was publicly announced in 1995. The first edition of the Journal of the National Comprehensive Cancer Network was published in 2003. NCCN Member Institutions Experts from the 33 NCCN Member Institutions are recognized for dealing with complex, aggressive, or rare cancers. The 33 NCCN Member Institutions are: * Perelman Center for Advanced Medicine, Abramson Cancer Center of the Univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AKT1
RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the ''AKT1'' gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. It is commonly referred to as PKB, or by both names as "Akt/PKB". Function The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ubiquitin
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A. The addition of ubiquitin to a substrate protein is called ubiquitylation (or ubiquitination or ubiquitinylation). Ubiquitylation affects proteins in many ways: it can mark them for degradation via the 26S proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitylation involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade is to bind ubiquitin to lysine residues on the protein substrate via an isopeptide bond, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Avram Hershko
Avram Hershko (, ; born December 31, 1937) is an Hungarian-born Israeli biochemist who received the Nobel Prize in Chemistry in 2004. Biography He was born Herskó Ferenc in Karcag, Hungary, into a Jewish family, the son of Shoshana/Margit 'Manci' (née Wulc) and Moshe Hershko, both teachers. including the Nobel Lecture ''The Ubiquitin System for Protein Degradation and some of its Roles in the Control of the Cell Division Cycle'' During the Second World War, his father was forced into labor service in the Hungarian army and then taken as a prisoner by the Soviet Army. For years, Avram's family didn't known anything about what had happened to his father. Avram, his mother and older brother Chaim/Laszlo 'Laci' were put in a ghetto in Szolnok. During the final days of the ghetto, most Jews were sent to be murdered in Auschwitz, but Avram and his family managed to board trains that took them to a concentration camp in Austria, where they were forced into labor until the end o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aaron Ciechanover
Aaron Ciechanover ( ; ; born October 1, 1947) is an Israeli biologist who won the Nobel Prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin. Biography Early life Ciechanover was born in Haifa, British Mandate of Palestine on 1 October 1947 into a Jewish family. He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker in a law firm. His parents immigrated to Israel from Poland in the 1920s. Education He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981 to 1984. Recent Ciechanover is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Med ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irwin Rose
Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. Education and early life Rose was born in Brooklyn, New York, into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store. including the Nobel Lecture on December 8, 2004 ''Ubiquitin at Fox Chase'' Rose attended Washington State University for one year prior to serving in the Navy during World War II. Upon returning from the war he received his Bachelor of Science degree in 1948 and his PhD in biochemistry in 1952, both from the University of Chicago. He did his post-doctoral studies at NYU. Career and research Rose served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined the Fox Chase Cancer Center in 1963 and stayed there until he retired in 199 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Chemistry
The Nobel Prize in Chemistry () is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature, peace, and physiology or medicine. This award is administered by the Nobel Foundation and awarded by the Royal Swedish Academy of Sciences on proposal of the Nobel Committee for Chemistry, which consists of five members elected by the Academy. The award is presented in Stockholm at an annual ceremony on December 10th, the anniversary of Nobel's death. The first Nobel Prize in Chemistry was awarded in 1901 to Jacobus Henricus van 't Hoff, of the Netherlands, "for his discovery of the laws of chemical dynamics and osmotic pressure in solutions". From 1901 to 2024, the award has been bestowed on a total of 195 individuals. The 2024 Nobel Prize in Chemistry was awarded to Demis Hassabis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alfred G
Alfred may refer to: Arts and entertainment *'' Alfred J. Kwak'', Dutch-German-Japanese anime television series * ''Alfred'' (Arne opera), a 1740 masque by Thomas Arne * ''Alfred'' (Dvořák), an 1870 opera by Antonín Dvořák *"Alfred (Interlude)" and "Alfred (Outro)", songs by Eminem from the 2020 album '' Music to Be Murdered By'' Business and organisations * Alfred, a radio station in Shaftesbury, England * Alfred Music, an American music publisher * Alfred University, New York, U.S. * The Alfred Hospital, a hospital in Melbourne, Australia People * Alfred (name) includes a list of people and fictional characters called Alfred * Alfred the Great (848/49 – 899), or Alfred I, a king of the West Saxons and of the Anglo-Saxons Places Antarctica * Mount Alfred (Antarctica) Australia * Alfredtown, New South Wales * County of Alfred, South Australia Canada * Alfred and Plantagenet, Ontario ** Alfred, Ontario, a community in Alfred and Plantagenet * Alfred Island, Nunavu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kyoto Prize
The is Japan's highest private award for lifetime achievement in the arts and sciences. It is given not only to those that are top representatives of their own respective fields, but to "those who have contributed significantly to the scientific, cultural, and spiritual betterment of mankind". The Kyoto Prize was established in 1984, and the laureates have been annually awarded since 1985. It is regarded by many as Japan's version of the Nobel Prize, representing one of the most prestigious awards available in fields that are not traditionally honored with a Nobel. The prizes are endowed with 100 million yen per category and have been awarded annually since 1985 by the Inamori Foundation, founded by Kazuo Inamori. The laureates are announced each June; the prize presentation ceremony and related events are held in Kyoto, Japan, each November. Categories and fields The Kyoto Prize consists of three different categories, each with four subfields. The subfields rotate every ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Foundation For Cancer Research
National Foundation for Cancer Research (NFCR) is an American nonprofit organization founded in 1973. It provides funds to cancer scientists and researchers, with the ultimate goal of a cure for cancer. Awards The Szent-Györgyi Prize for Progress in Cancer Research, established by the NFCR and named in honor of Albert Szent-Györgyi Albert Imre Szent-Györgyi de Rapoltu Mare, Nagyrápolt (; September 16, 1893 – October 22, 1986) was a Hungarian biochemist who won the Nobel Prize in Physiology or Medicine in 1937. He is credited with first isolating vitamin C and disc ..., Nobel Laureate and co-founder of NFCR, has been awarded annually since 2006 to outstanding researchers whose scientific achievements have expanded the understanding of cancer and whose vision has moved cancer research in new directions. The Szent-Györgyi Prize honors researchers whose discoveries have made possible new approaches to preventing, diagnosing and/or treating cancer. References Exter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beatrice Mintz
Beatrice Mintz (January 24, 1921 – January 3, 2022) was an American embryologist who contributed to the understanding of genetic modification, cellular differentiation, and cancer, particularly melanoma.Martha J. Bailey, ''American women in science: a biographical dictionary, Vol. 1'', ABC-CLIO, 1994, p. 252, Mintz was a pioneer of genetic engineering techniques and was among the first scientists to generate both Chimera (genetics), chimeric and transgenic mammals. In 1996, she shared the inaugural March of Dimes Prize in Developmental Biology with Ralph L. Brinster for their work in developing transgenic mice. Much of her career was spent at Fox Chase Cancer Center in Philadelphia where, in 2002, she was appointed to the Jack Schultz Chair in Basic Science.Alumni Fellows, 2002 Recipients , The University of I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
