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F-statistics
In population genetics, ''F''-statistics (also known as fixation indices) describe the statistically expected level of heterozygosity in a population; more specifically the expected degree of (usually) a reduction in heterozygosity when compared to Hardy–Weinberg expectation. ''F''-statistics can also be thought of as a measure of the correlation between genes drawn at different levels of a (hierarchically) subdivided population. This correlation is influenced by several evolutionary processes, such as genetic drift, founder effect, bottleneck, genetic hitchhiking, meiotic drive, mutation, gene flow, inbreeding, natural selection, or the Wahlund effect, but it was originally designed to measure the amount of allelic fixation owing to genetic drift. The concept of ''F''-statistics was developed during the 1920s by the American geneticist Sewall Wright, who was interested in inbreeding in cattle. However, because complete dominance causes the phenotypes of homozygote dominan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
F-statistics
In population genetics, ''F''-statistics (also known as fixation indices) describe the statistically expected level of heterozygosity in a population; more specifically the expected degree of (usually) a reduction in heterozygosity when compared to Hardy–Weinberg expectation. ''F''-statistics can also be thought of as a measure of the correlation between genes drawn at different levels of a (hierarchically) subdivided population. This correlation is influenced by several evolutionary processes, such as genetic drift, founder effect, bottleneck, genetic hitchhiking, meiotic drive, mutation, gene flow, inbreeding, natural selection, or the Wahlund effect, but it was originally designed to measure the amount of allelic fixation owing to genetic drift. The concept of ''F''-statistics was developed during the 1920s by the American geneticist Sewall Wright, who was interested in inbreeding in cattle. However, because complete dominance causes the phenotypes of homozygote dominan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sewall Wright
Sewall Green Wright FRS(For) Honorary FRSE (December 21, 1889March 3, 1988) was an American geneticist known for his influential work on evolutionary theory and also for his work on path analysis. He was a founder of population genetics alongside Ronald Fisher and J. B. S. Haldane, which was a major step in the development of the modern synthesis combining genetics with evolution. He discovered the inbreeding coefficient and methods of computing it in pedigree animals. He extended this work to populations, computing the amount of inbreeding between members of populations as a result of random genetic drift, and along with Fisher he pioneered methods for computing the distribution of gene frequencies among populations as a result of the interaction of natural selection, mutation, migration and genetic drift. Wright also made major contributions to mammalian and biochemical genetics. Biography Sewall Wright was born in Melrose, Massachusetts to Philip Green Wright and Elizabeth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hardy–Weinberg Principle
In population genetics, the Hardy–Weinberg principle, also known as the Hardy–Weinberg equilibrium, model, theorem, or law, states that allele and genotype frequencies in a population will remain constant from generation to generation in the absence of other evolutionary influences. These influences include ''genetic drift'', '' mate choice'', ''assortative mating'', ''natural selection'', ''sexual selection'', ''mutation'', ''gene flow'', '' meiotic drive'', ''genetic hitchhiking'', ''population bottleneck'', ''founder effect,'' ''inbreeding and outbreeding depression''. In the simplest case of a single locus with two alleles denoted ''A'' and ''a'' with frequencies and , respectively, the expected genotype frequencies under random mating are for the AA homozygotes, for the aa homozygotes, and for the heterozygotes. In the absence of selection, mutation, genetic drift, or other forces, allele frequencies ''p'' and ''q'' are constant between generations, so equilibriu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Population Genetics
Population genetics is a subfield of genetics that deals with genetic differences within and between populations, and is a part of evolutionary biology. Studies in this branch of biology examine such phenomena as adaptation, speciation, and population structure. Population genetics was a vital ingredient in the emergence of the modern evolutionary synthesis. Its primary founders were Sewall Wright, J. B. S. Haldane and Ronald Fisher, who also laid the foundations for the related discipline of quantitative genetics. Traditionally a highly mathematical discipline, modern population genetics encompasses theoretical, laboratory, and field work. Population genetic models are used both for statistical inference from DNA sequence data and for proof/disproof of concept. What sets population genetics apart from newer, more phenotypic approaches to modelling evolution, such as evolutionary game theory and adaptive dynamics, is its emphasis on such genetic phenomena as dominance, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coefficient Of Relationship
The coefficient of relationship is a measure of the degree of consanguinity (or biological relationship) between two individuals. The term coefficient of relationship was defined by Sewall Wright in 1922, and was derived from his definition of the coefficient of inbreeding of 1921. The measure is most commonly used in genetics and genealogy. A coefficient of inbreeding can be calculated for an individual, and is typically one-half the coefficient of relationship between the parents. In general, the higher the level of inbreeding the closer the coefficient of relationship between the parents approaches a value of 1, expressed as a percentage, and approaches a value of 0 for individuals with arbitrarily remote common ancestors. Coefficient of relationship The coefficient of relationship ( r ) between two individuals B and C is obtained by a summation of coefficients calculated for every line by which they are connected to their common ancestors. Each such line connects the two i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fixation Index
The fixation index (FST) is a measure of population differentiation due to genetic structure. It is frequently estimated from genetic polymorphism data, such as single-nucleotide polymorphisms (SNP) or microsatellites. Developed as a special case of Wright's F-statistics, it is one of the most commonly used statistics in population genetics. Definition Two of the most commonly used definitions for FST at a given locus are based on 1) the variance of allele frequencies between populations, and on 2) the probability of Identity by descent. If \bar is the average frequency of an allele in the total population, \sigma^2_S is the variance in the frequency of the allele between different subpopulations, weighted by the sizes of the subpopulations, and \sigma^2_T is the variance of the allelic state in the total population, FST is defined as : F_ = \frac = \frac Wright's definition illustrates that FST measures the amount of genetic variance that can be explained by population stru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inbreeding
Inbreeding is the production of offspring from the mating or breeding of individuals or organisms that are closely related genetically. By analogy, the term is used in human reproduction, but more commonly refers to the genetic disorders and other consequences that may arise from expression of deleterious or recessive traits resulting from incestuous sexual relationships and consanguinity. Animals avoid incest only rarely. Inbreeding results in homozygosity, which can increase the chances of offspring being affected by recessive traits. In extreme cases, this usually leads to at least temporarily decreased biological fitness of a population (called inbreeding depression), which is its ability to survive and reproduce. An individual who inherits such deleterious traits is colloquially referred to as ''inbred''. The avoidance of expression of such deleterious recessive alleles caused by inbreeding, via inbreeding avoidance mechanisms, is the main selective reason fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Effective Population Size
The effective population size (''N''''e'') is a number that, in some simplified scenarios, corresponds to the number of breeding individuals in the population. More generally, ''N''''e'' is the number of individuals that an idealised population would need to have in order for some specified quantity of interest (typically change of genetic diversity or inbreeding rates) to be the same as in the real population. Idealised populations are based on unrealistic but convenient simplifications such as random mating, simultaneous birth of each new generation, constant population size, and equal numbers of children per parent. For most quantities of interest and most real populations, the effective population size ''N''''e'' is usually smaller than the census population size ''N'' of a real population. The same population may have multiple effective population sizes, for different properties of interest, including for different genetic loci. The effective population size is most commonly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wahlund Effect
In population genetics, the Wahlund effect is a reduction of heterozygosity (that is when an organism has two different alleles at a locus) in a population caused by subpopulation structure. Namely, if two or more subpopulations are in a Hardy–Weinberg equilibrium but have different allele frequencies, the overall heterozygosity is reduced compared to if the whole population was in equilibrium. The underlying causes of this population subdivision could be geographic barriers to gene flow followed by genetic drift in the subpopulations. The Wahlund effect was first described by the Swedish geneticist Sten Wahlund in 1928. Simplest example Suppose there is a population P, with allele frequencies of A and a given by p and q respectively (p + q = 1). Suppose this population is split into two equally-sized subpopulations, P_1 and P_2, and that all the ''A'' alleles are in subpopulation P_1 and all the ''a'' alleles are in subpopulation P_2 (this could occur due to drift). Then, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
F-distribution
In probability theory and statistics, the ''F''-distribution or F-ratio, also known as Snedecor's ''F'' distribution or the Fisher–Snedecor distribution (after Ronald Fisher and George W. Snedecor) is a continuous probability distribution that arises frequently as the null distribution of a test statistic, most notably in the analysis of variance (ANOVA) and other ''F''-tests. Definition The F-distribution with ''d''1 and ''d''2 degrees of freedom is the distribution of : X = \frac where S_1 and S_2 are independent random variables with chi-square distributions with respective degrees of freedom d_1 and d_2. It can be shown to follow that the probability density function (pdf) for ''X'' is given by : \begin f(x; d_1,d_2) &= \frac \\ pt&=\frac \left(\frac\right)^ x^ \left(1+\frac \, x \right)^ \end for real ''x'' > 0. Here \mathrm is the beta function. In many applications, the parameters ''d''1 and ''d''2 are positive integers, but the distribution is well- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenotype
In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology (biology), morphology or physical form and structure, its Developmental biology, developmental processes, its biochemical and physiological properties, its behavior, and the products of behavior. An organism's phenotype results from two basic factors: the Gene expression, expression of an organism's genetic code, or its genotype, and the influence of environmental factors. Both factors may interact, further affecting phenotype. When two or more clearly different phenotypes exist in the same population of a species, the species is called Polymorphism (biology), polymorphic. A well-documented example of polymorphism is Labrador Retriever coat colour genetics, Labrador Retriever coloring; while the coat color depends on many genes, it is clearly seen in the environment as yellow, black, and brown. Richard Dawkins in 1978 and then again i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scarlet Tiger Moth
The scarlet tiger moth (''Callimorpha dominula'', formerly ''Panaxia dominula'') is a colorful moth belonging to the tiger moth subfamily, Arctiinae. The species was first described by Carl Linnaeus in his 1758 10th edition of ''Systema Naturae''. Subspecies Subspecies within this species include: * ''Callimorpha dominula dominula'' (Linnaeus, 1758) (Baltic, Belarus, Ukraine, Moldova, western Russia and central Europe) * ''Callimorpha dominula lusitanica'' Staudinger, 1894 (Portugal) * ''Callimorpha dominula pompalis'' Nitsche, 926/small> (valleys of the southern Alps) * ''Callimorpha dominula persona'' (Hübner, 1790) (Italy south of the Alps, excluding Piedmont and southern Alpine valleys) * ''Callimorpha dominula trinacriae'' Nardelli & Giandolfo, 1996 (Sicily) * ''Callimorpha dominula profuga'' (Goeze, 1781) (Balkans: Macedonia (Scopje); Albania; Greece; western Turkey) * ''Callimorpha dominula rossica'' Kolenati, 1846 (Caucasus, Transcaucasia, except Talysh Mountains; north ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
