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Edwin Goldmann
Edwin Goldmann (12 November 1862 – 13 August 1913) was a biomedical researcher and surgeon most famous for his contributions in first characterizing the blood–brain barrier. Discovery of the blood–brain barrier Goldmann's mentor, Paul Ehrlich, was studying staining in his bacteriological studies by injecting aniline dyes in several species of animal. While most of the anatomy stained equally well, the brain tissue exhibited less staining in many species. Goldmann discovered that when the dye (namely, trypan blue) was injected directly into the central nervous system instead of into the other organs, the brain would stain equally well as other organs — but the stain would not travel to the rest of the body. This suggested the presence of a compartmentalization between the cerebrospinal fluid and the vasculature of the rest of the body. This barrier was first hypothesized by a Berlin physician, Max Lewandowsky, in 1900 (prior to Goldmann's empirical evidence). Edwi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burgersdorp
Burgersdorp is a medium-sized town in Walter Sisulu in the Joe Gqabi District Municipality of the Eastern Cape province of South Africa. In 1869 a Theological Seminary was established here by the ''Gereformeerde Kerk'', but in 1905 it was moved to Potchefstroom, acting as an instrument in the formation of the PUK in 1919, then becoming the Potchefstroom University for Christian Higher Education in 1951. The Afrikaner Bond political party was founded in Burgersdorp in 1881. Demographics According to the 2011 census, the town of Burgersdorp proper has a population of 5,240, while the adjacent townships of Mzamomhle and Tembisa have populations of 4,656 and 6,094 respectively, giving the urban area a population of 15,990. Of this population 78.1% described themselves as Black African, 11.98% as Coloured and 9.4% as White. 69.2% spoke Xhosa as their home language, 20.1% spoke Afrikaans, 3.3% spoke Sotho, 1.4% spoke English as their home language and 6.0% spoke some other languag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organ (anatomy)
In biology, an organ is a collection of tissues joined in a structural unit to serve a common function. In the hierarchy of life, an organ lies between tissue and an organ system. Tissues are formed from same type cells to act together in a function. Tissues of different types combine to form an organ which has a specific function. The intestinal wall for example is formed by epithelial tissue and smooth muscle tissue. Two or more organs working together in the execution of a specific body function form an organ system, also called a biological system or body system. An organ's tissues can be broadly categorized as parenchyma, the functional tissue, and stroma, the structural tissue with supportive, connective, or ancillary functions. For example, the gland's tissue that makes the hormones is the parenchyma, whereas the stroma includes the nerves that innervate the parenchyma, the blood vessels that oxygenate and nourish it and carry away its metabolic wastes, and the con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1862 Births
Year 186 ( CLXXXVI) was a common year starting on Saturday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Aurelius and Glabrio (or, less frequently, year 939 ''Ab urbe condita''). The denomination 186 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Peasants in Gaul stage an anti-tax uprising under Maternus. * Roman governor Pertinax escapes an assassination attempt, by British usurpers. New Zealand * The Hatepe volcanic eruption extends Lake Taupō and makes skies red across the world. However, recent radiocarbon dating by R. Sparks has put the date at 233 AD ± 13 (95% confidence). Births * Ma Liang, Chinese official of the Shu Han state (d. 222) Deaths * April 21 – Apollonius the Apologist, Christian martyr * Bian Zhang, Chinese official and g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
South African Surgeons
South is one of the cardinal directions or compass points. The direction is the opposite of north and is perpendicular to both east and west. Etymology The word ''south'' comes from Old English ''sūþ'', from earlier Proto-Germanic ''*sunþaz'' ("south"), possibly related to the same Proto-Indo-European root that the word ''sun'' derived from. Some languages describe south in the same way, from the fact that it is the direction of the sun at noon (in the Northern Hemisphere), like Latin meridies 'noon, south' (from medius 'middle' + dies 'day', cf English meridional), while others describe south as the right-hand side of the rising sun, like Biblical Hebrew תֵּימָן teiman 'south' from יָמִין yamin 'right', Aramaic תַּימנַא taymna from יָמִין yamin 'right' and Syriac ܬܰܝܡܢܳܐ taymna from ܝܰܡܝܺܢܳܐ yamina (hence the name of Yemen, the land to the south/right of the Levant). Navigation By convention, the ''bottom or down-facing side'' of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Baltimore Sun
''The Baltimore Sun'' is the largest general-circulation daily newspaper based in the U.S. state of Maryland and provides coverage of local and regional news, events, issues, people, and industries. Founded in 1837, it is currently owned by Tribune Publishing. The ''Baltimore Sun's'' parent company, '' Tribune Publishing'', was acquired by Alden Global Capital, which operates its media properties through Digital First Media, in May 2021. History ''The Sun'' was founded on May 17, 1837, by printer/editor/publisher/owner Arunah Shepherdson Abell (often listed as "A. S. Abell") and two associates, William Moseley Swain, and Azariah H. Simmons, recently from Philadelphia, where they had started and published the '' Public Ledger'' the year before. Abell was born in Rhode Island, became a journalist with the ''Providence Patriot'' and later worked with newspapers in New York City and Boston.Van Doren, Charles and Robert McKendry, ed., ''Webster's American Biographies''. (Spring ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Lewandowsky
upPortrait of Lewandowsky Max Lewandowsky (28 June 1876 – 4 April 1916) was a German neurologist, who was a native of Berlin, born into a Jewish family. Personal life Lewandowsky studied medicine at the Universities of Marburg, Berlin and Halle, earning his medical doctorate at Halle in 1898. In 1902 he obtained his post-graduate qualification for physiology, and in 1904, received training in clinical neurology and psychiatry under Karl Bonhoeffer and Franz Nissl at the University of Heidelberg. Afterwards he travelled to Paris, where he studied under neurologist Pierre Marie. Beginning in 1905 he worked in the Berlin-Friedrichshain hospital.Deutschsprachige Neurologen und Psychiater: Ein biographisch by Alma Kreuter During |
Berlin
Berlin ( , ) is the capital and List of cities in Germany by population, largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's List of cities in the European Union by population within city limits, most populous city, according to population within city limits. One of Germany's States of Germany, sixteen constituent states, Berlin is surrounded by the Brandenburg, State of Brandenburg and contiguous with Potsdam, Brandenburg's capital. Berlin's urban area, which has a population of around 4.5 million, is the second most populous urban area in Germany after the Ruhr. The Berlin/Brandenburg Metropolitan Region, Berlin-Brandenburg capital region has around 6.2 million inhabitants and is Metropolitan regions in Germany, Germany's third-largest metropolitan region after the Rhine-Ruhr and Frankfurt Rhine-Main, Rhine-Main regions. Berlin straddles the banks of the Spree (river), Spree, which flows into the Havel (a tributary of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Circulatory System
The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, that consists of the heart and blood vessels (from Greek ''kardia'' meaning ''heart'', and from Latin ''vascula'' meaning ''vessels''). The circulatory system has two divisions, a systemic circulation or circuit, and a pulmonary circulation or circuit. Some sources use the terms ''cardiovascular system'' and ''vascular system'' interchangeably with the ''circulatory system''. The network of blood vessels are the great vessels of the heart including large elastic arteries, and large veins; other arteries, smaller arterioles, capillaries that join with venules (small veins), and other veins. The circulatory system is closed in vertebrates, which means that the blood never leaves the network of blood vessels. Some invertebrates such as a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the brain, and absorbed in the arachnoid granulations. There is about 125 mL of CSF at any one time, and about 500 mL is generated every day. CSF acts as a shock absorber, cushion or buffer, providing basic mechanical and immunological protection to the brain inside the skull. CSF also serves a vital function in the cerebral autoregulation of cerebral blood flow. CSF occupies the subarachnoid space (between the arachnoid mater and the pia mater) and the ventricular system around and inside the brain and spinal cord. It fills the ventricles of the brain, cisterns, and sulci, as well as the central canal of the spinal cord. There is also a connection from the subarachnoid space to the bony labyrinth of the inner ear via the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Central Nervous System
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and diploblasts. It is a structure composed of nervous tissue positioned along the rostral (nose end) to caudal (tail end) axis of the body and may have an enlarged section at the rostral end which is a brain. Only arthropods, cephalopods and vertebrates have a true brain (precursor structures exist in onychophorans, gastropods and lancelets). The rest of this article exclusively discusses the vertebrate central nervous system, which is radically distinct from all other animals. Overview In vertebrates, the brain and spinal cord are both enclosed in the meninges. The meninges provide a barrier to chemicals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Freiburg Im Breisgau
Freiburg im Breisgau (; abbreviated as Freiburg i. Br. or Freiburg i. B.; Low Alemannic: ''Friburg im Brisgau''), commonly referred to as Freiburg, is an independent city in Baden-Württemberg, Germany. With a population of about 230,000 (as of 31 December 2018), Freiburg is the fourth-largest city in Baden-Württemberg after Stuttgart, Mannheim, and Karlsruhe. The population of the Freiburg metropolitan area was 656,753 in 2018. In the south-west of the country, it straddles the Dreisam river, at the foot of the Schlossberg. Historically, the city has acted as the hub of the Breisgau region on the western edge of the Black Forest in the Upper Rhine Plain. A famous old German university town, and archiepiscopal seat, Freiburg was incorporated in the early twelfth century and developed into a major commercial, intellectual, and ecclesiastical center of the upper Rhine region. The city is known for its medieval minster and Renaissance university, as well as for its high stand ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypan Blue
Trypan blue is an azo dye. It is a direct dye for cotton textiles. In biosciences, it is used as a vital stain to selectively colour dead tissues or cells blue. Live cells or tissues with intact cell membranes are not coloured. Since cells are very selective in the compounds that pass through the membrane, in a viable cell trypan blue is not absorbed; however, it traverses the membrane in a dead cell. Hence, dead cells appear as a distinctive blue colour under a microscope. Since live cells are excluded from staining, this staining method is also described as a dye exclusion method. Background and chemistry Trypan blue is derived from toluidine, that is, any of several isomeric bases, C14H16N2, derived from toluene. Trypan blue is so-called because it can kill trypanosomes, the parasites that cause sleeping sickness. An analog of trypan blue, suramin, is used pharmacologically against trypanosomiasis. Trypan blue is also known as diamine blue and Niagara blue. The extincti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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