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EFSH
eFSH is a follicle-stimulating hormone obtained from equine species, used to stimulate fertility. Clinical studies The effects of eFSH on mares is observed by creating a treatment group that received 12.5 milligrams of eFSA injections twice a day when the follicle of the mare was 25 mm in diameter then received human chorionic gonadotropin(hCG) at 35 mm follicle diameter while a control group only receives hCG at 35 mm follicle diameter. Embryo transfer The application of utilizing eFSH to increase the efficiency of equine embryo transfer was tested at the University of Saskatchewan. Embryos from 12 donor mares at 8 days of ovulation were recovered, scored, then transferred to 37 recipients mares who were tested for pregnancy after 7-10 days. 5 pregnancies resulted from the 15 embryos were recovered from the eFSA treatment group and 4 pregnancies occurred from the 6 embryos collected from the control. The usage of eFSA in the study had a correlation with a lower score. E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Follicle-stimulating Hormone
Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone. FSH is synthesized and secreted by the gonadotropic cells of the anterior pituitary gland and regulates the development, growth, pubertal maturation, and reproductive processes of the body. FSH and luteinizing hormone (LH) work together in the reproductive system. Structure FSH is a 35.5 kDa glycoprotein heterodimer, consisting of two polypeptide units, alpha and beta. Its structure is similar to those of luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist of 96 amino acids, while the beta subunits vary. Both subunits are required for biological activity. FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor. The sugar p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Horse
The horse (''Equus ferus caballus'') is a domesticated, one-toed, hoofed mammal. It belongs to the taxonomic family Equidae and is one of two extant subspecies of ''Equus ferus''. The horse has evolved over the past 45 to 55 million years from a small multi-toed creature, '' Eohippus'', into the large, single-toed animal of today. Humans began domesticating horses around 4000 BCE, and their domestication is believed to have been widespread by 3000 BCE. Horses in the subspecies ''caballus'' are domesticated, although some domesticated populations live in the wild as feral horses. These feral populations are not true wild horses, as this term is used to describe horses that have never been domesticated. There is an extensive, specialized vocabulary used to describe equine-related concepts, covering everything from anatomy to life stages, size, colors, markings, breeds, locomotion, and behavior. Horses are adapted to run, allowing them to quickly escape predators, and po ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mare
A mare is an adult female horse or other equine. In most cases, a mare is a female horse over the age of three, and a filly is a female horse three and younger. In Thoroughbred horse racing, a mare is defined as a female horse more than four years old. The word can also be used for other female equine animals, particularly mules and zebras, but a female donkey is usually called a "jenny". A broodmare is a mare used for breeding. A horse's female parent is known as its dam. Reproductive cycle Mares carry their young (called foals) for approximately 11 months from conception to birth. (Average range 320–370 days.)Ensminger, M. E. ''Horses and Horsemanship: Animal Agriculture Series.'' Sixth Edition. Interstate Publishers, 1990. p. 156 Usually just one young is born; twins are rare. When a domesticated mare foals, she nurses the foal for at least four to six months before it is weaned, though mares in the wild may allow a foal to nurse for up to a year. The estro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Treatment Group
In the design of experiments, hypotheses are applied to experimental units in a treatment group. In comparative experiments, members of a control group receive a standard treatment, a placebo, or no treatment at all. There may be more than one treatment group, more than one control group, or both. A placebo control group can be used to support a double-blind study, in which some subjects are given an ineffective treatment (in medical studies typically a sugar pill) to minimize differences in the experiences of subjects in the different groups; this is done in a way that ensures no participant in the experiment (subject or experimenter) knows to which group each subject belongs. In such cases, a third, non-treatment control group can be used to measure the placebo effect directly, as the difference between the responses of placebo subjects and untreated subjects, perhaps paired by age group or other factors (such as being twins). For the conclusions drawn from the results of an e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ovarian Follicle
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle. At the time of puberty, women have approximately 200,000 to 300,000 follicles, each with the potential to release an egg cell (ovum) at ovulation for fertilization. These eggs are developed once every menstrual cycle with around 450–500 being ovulated during a woman's reproductive lifetime. Structure Ovarian follicles are the basic units of female reproductive biology. Each of them contains a single oocyte (immature ovum or egg cell). These structures are periodically initiated to grow and develop, culminating in ovulation of usually a single competent oocyte in humans. They also consist of granulosa cells and theca of follicle. Oocyte Once a month, one of the ovaries releases a mature egg (ovum), known as an oocyte. The nucleus of such an oocyte is called a '' germinal vesicle (see picture).'' Cumulus oophorus C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Chorionic Gonadotropin
Human chorionic gonadotropin (hCG) is a hormone for the maternal recognition of pregnancy produced by trophoblast cells that are surrounding a growing embryo (syncytiotrophoblast initially), which eventually forms the placenta after implantation. The presence of hCG is detected in some pregnancy tests (HCG pregnancy strip tests). Some cancerous tumors produce this hormone; therefore, elevated levels measured when the patient is not pregnant may lead to a cancer diagnosis and, if high enough, paraneoplastic syndromes, however, it is not known whether this production is a contributing cause, or an effect of carcinogenesis. The pituitary analog of hCG, known as luteinizing hormone (LH), is produced in the pituitary gland of males and females of all ages. Various endogenous forms of hCG exist. The measurement of these diverse forms is used in the diagnosis of pregnancy and a variety of disease states. Preparations of hCG from various sources have also been used therapeutically, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Saskatchewan
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The universit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Embryo Quality
Embryo quality is the ability of an embryo to perform successfully in terms of conferring a high pregnancy rate and/or resulting in a healthy person. Embryo profiling is the estimation of embryo quality by qualification and/or quantification of various parameters. Estimations of embryo quality guides the choice in embryo selection in ''in vitro'' fertilization. In general, embryo profiling for prediction of pregnancy rates focuses mainly on visual profiles and short-term biomarkers including expression of RNA and proteins, preferably in the surroundings of embryos to avoid any damage to them. On the other hand, embryo profiling for health prediction puts more focus on the genome, and where there is a risk of a genetic disorder it more often involves cell sampling from the embryo for preimplantation genetic diagnosis. Prediction of pregnancy rates Microscopy Embryo quality is mainly evaluated by microscopy at certain time points using a morphological scoring system. This has sho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Kentucky
The University of Kentucky (UK, UKY, or U of K) is a public land-grant research university in Lexington, Kentucky. Founded in 1865 by John Bryan Bowman as the Agricultural and Mechanical College of Kentucky, the university is one of the state's two land-grant universities (the other being Kentucky State University) and the institution with the highest enrollment in the state, with 30,545 students as of fall 2019. The institution comprises 16 colleges, a graduate school, 93 undergraduate programs, 99 master programs, 66 doctoral programs, and four professional programs. It is classified among "R1: Doctoral Universities – Very high research activity". According to the National Science Foundation, Kentucky spent $393 million on research and development in 2018, ranking it 63rd in the nation. The University of Kentucky has fifteen libraries on campus. The largest is the William T. Young Library, a federal depository, hosting subjects related to social sciences, humanities, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Superovulation
Controlled ovarian hyperstimulation is a technique used in assisted reproduction involving the use of fertility medications to induce ovulation by multiple ovarian follicles. These multiple follicles can be taken out by oocyte retrieval (egg collection) for use in ''in vitro'' fertilisation (IVF), or be given time to ovulate, resulting in superovulation which is the ovulation of a larger-than-normal number of eggs, generally in the sense of at least two. When ovulated follicles are fertilised ''in vivo'', whether by natural or artificial insemination, there is a very high risk of a multiple pregnancy. In this article, unless otherwise specified, hyperstimulation will refer to hyperstimulation as part of IVF. In contrast, ovulation induction is ovarian stimulation without subsequent IVF, with the aim of developing one or two ovulatory follicles (the maximum number before recommending sexual abstinence with such treatment). Procedure Response prediction Response predictors determi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Equine Chorionic Gonadotropin
Equine chorionic gonadotropin (acronym given as eCG but not to be confused with ECG) is a gonadotropic hormone produced in the chorion of pregnant mares. Previously referred to as pregnant mare's serum gonadotropin (PMSG), the hormone is commonly used in concert with progestogen to induce ovulation in livestock prior to artificial insemination. Pregnant mares secrete the hormone from their endometrial cups between 40 and 130 days into their gestation, and once collected, it has been used to artificially induce estrus in female sheep, goats, cattle, and swine. Despite being less pure than pituitary extracts from sheep, goats or swine, PMSG tends to be used because of its longer circulatory half-life. In equids PMSG has only LH like activity, but in other species it has activity like both follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Equine CG, like all glycoprotein hormones, is composed of two dissimilar subunits named alpha and beta. The alpha subunit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Samples
In medicine, venipuncture or venepuncture is the process of obtaining intravenous access for the purpose of venous blood sampling (also called ''phlebotomy'') or intravenous therapy. In healthcare, this procedure is performed by medical laboratory scientists, medical practitioners, some EMTs, paramedics, phlebotomists, dialysis technicians, and other nursing staff. In veterinary medicine, the procedure is performed by veterinarians and veterinary technicians. It is essential to follow a standard procedure for the collection of blood specimens to get accurate laboratory results. Any error in collecting the blood or filling the test tubes may lead to erroneous laboratory results. Venipuncture is one of the most routinely performed invasive procedures and is carried out for any of five reasons: # to obtain blood for diagnostic purposes; # to monitor levels of blood components; # to administer therapeutic treatments including medications, nutrition, or chemotherapy; # to remov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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