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European Reference Genome Atlas
The European Reference Genome Atlas (ERGA) is a community initiative coordinating the production of a reference genome for all eukaryotic species in Europe. This involves field sampling and DNA sequencing, followed by sequence assembly and annotation, to generate a catalogue of genomes that meet reference quality standards. As the European regional node of the Earth BioGenome Project (EBP), ERGA collaborates with other genome projects worldwide, such as the African BioGenome Project and the Vertebrate Genomes Project __TOC__ Background ERGA was launched in 2020 to build a European initiative with a focus on reference genome production. Community formalisation included establishing the Council of representatives from all participating countries and setting up the Committees to oversee the main stages of the genome generation workflow. Community establishment continued through activities of the Council and Committees, setting up of Core Projects, partnering with technology provid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reference Genome
A reference genome (also known as a reference assembly) is a digital nucleic acid sequence database, assembled by scientists as a representative example of the genome, set of genes in one idealized individual organism of a species. As they are assembled from the sequencing of DNA from a number of individual donors, reference genomes do not accurately represent the set of genes of any single individual organism. Instead, a reference provides a haploid mosaic of different DNA sequences from each donor. For example, one of the most recent human reference genomes, assembly ''GRCh38, GRCh38/hg38'', is derived from >60 genomic library, genomic clone libraries. There are reference genomes for multiple species of viruses, bacteria, fungus, plants, and animals. Reference genomes are typically used as a guide on which new genomes are built, enabling them to be assembled much more quickly and cheaply than the initial Human Genome Project. Reference genomes can be accessed online at several ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eukaryote
The eukaryotes ( ) constitute the Domain (biology), domain of Eukaryota or Eukarya, organisms whose Cell (biology), cells have a membrane-bound cell nucleus, nucleus. All animals, plants, Fungus, fungi, seaweeds, and many unicellular organisms are eukaryotes. They constitute a major group of Outline of life forms, life forms alongside the two groups of prokaryotes: the Bacteria and the Archaea. Eukaryotes represent a small minority of the number of organisms, but given their generally much larger size, their collective global biomass is much larger than that of prokaryotes. The eukaryotes emerged within the archaeal Kingdom (biology), kingdom Asgard (Archaea), Promethearchaeati and its sole phylum Promethearchaeota. This implies that there are only Two-domain system, two domains of life, Bacteria and Archaea, with eukaryotes incorporated among the Archaea. Eukaryotes first emerged during the Paleoproterozoic, likely as Flagellated cell, flagellated cells. The leading evolutiona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Europe
Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere. It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, the Mediterranean Sea to the south, and Asia to the east. Europe shares the landmass of Eurasia with Asia, and of Afro-Eurasia with both Africa and Asia. Europe is commonly considered to be Boundaries between the continents#Asia and Europe, separated from Asia by the Drainage divide, watershed of the Ural Mountains, the Ural (river), Ural River, the Caspian Sea, the Greater Caucasus, the Black Sea, and the waterway of the Bosporus, Bosporus Strait. "Europe" (pp. 68–69); "Asia" (pp. 90–91): "A commonly accepted division between Asia and Europe ... is formed by the Ural Mountains, Ural River, Caspian Sea, Caucasus Mountains, and the Black Sea with its outlets, the Bosporus and Dardanelles." Europe covers approx. , or 2% of Earth#Surface, Earth's surface (6.8% of Earth's land area), making it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, thymine, cytosine, and guanine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, Genographic Project, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid advancements in DNA seque ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sequence Assembly
In bioinformatics, sequence assembly refers to aligning and merging fragments from a longer DNA sequence in order to reconstruct the original sequence. This is needed as DNA sequencing technology might not be able to 'read' whole genomes in one go, but rather reads small pieces of between 20 and 30,000 bases, depending on the technology used. Typically, the short fragments (reads) result from shotgun sequencing genomic DNA, or gene transcript ( ESTs). The problem of sequence assembly can be compared to taking many copies of a book, passing each of them through a shredder with a different cutter, and piecing the text of the book back together just by looking at the shredded pieces. Besides the obvious difficulty of this task, there are some extra practical issues: the original may have many repeated paragraphs, and some shreds may be modified during shredding to have typos. Excerpts from another book may also be added in, and some shreds may be completely unrecognizable. Types ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Earth BioGenome Project
The Earth BioGenome Project (EBP) is an initiative that aims to sequence and catalog the genomes of all of Earth's currently described eukaryotic species over a period of ten years. The initiative would produce an open DNA database of biological information that provides a platform for scientific research and supports environmental and conservation initiatives. A scientific paper presenting the vision for the project was published in ''PNAS'' in April 2018, and the project officially launched November 1, 2018. The initiative was inspired by Human Genome Project, and emerged during November 2015 meeting between Harris Lewin ( UCD), Gene E. Robinson ( IGB) and W. John Kress (Smithsonian Institution's National Museum of Natural History). In February 2017, at major conference on genomics and biodiversity organized by the Smithsonian Institution and BGI in Washington, D.C. was supported project's 10-year plan and organizational structure. Summary The project is projected to cost ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
African BioGenome Project
The African BioGenome Project, or AfricaBP, is an international effort to sequence the genomes of all animals, all plants, all fungi, and all protists (and so, collectively, all eukaryotes) that are native to Africa at an estimated cost of $1 billion U.S. dollars. The project prioritizes doing its sequencing work and data storage within the African continent. Background The project was originally started by a group of scientists including ThankGod Echezona Ebenezer, and has partnered with other major sequencing efforts such as the Vertebrate Genomes Project The Vertebrate Genomes Project (VGP) is a project which aims to generate high-quality, complete reference genomes of all 66,000 vertebrate species. It is an international cooperation project with members from more than 50 separate institutions and ... and the 10,000 Plant Genomes Project. References {{bioinformatics-stub Genome projects Genomics Bioinformatics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vertebrate Genomes Project
The Vertebrate Genomes Project (VGP) is a project which aims to generate high-quality, complete reference genomes of all 66,000 vertebrate species. It is an international cooperation project with members from more than 50 separate institutions and was launched in February 2017. In October 2021, VGP partnered with Colossal Biosciences to sequence and assemble elephant genomes for preservation purposes. In April 2022, VGP partnered with the Human Genome Project and the African BioGenome Project for sequencing research. In July 2022, VGP and Colossal Biosciences announced that they successfully sequenced the entire Asian elephant genome; this is the first time that mammalian genetic code has been fully sequenced to this degree since the Human Genome Project was completed in the early 2000s. In November 2022, VGP successfully sequenced the Nile Rat genome in order to facilitate research on type 2 diabetes and the health effects of circadian rhythm disruption. Not only did research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pacific Biosciences
Pacific Biosciences of California, Inc. (aka PacBio) is an American biotechnology company founded in 2004 that develops and manufactures systems for gene sequencing and some novel real time biological observation. PacBio has two principal sequencing platforms: single-molecule real-time sequencing (SMRT), based on the properties of zero-mode waveguides and sequencing by binding (SBB) chemistry, which uses native nucleotides and scarless incorporation for DNA binding and extension. History The company was founded based on research done at Cornell University that combined semiconductor processing and photonics with biotechnology research. Three graduate students in the lab of Professors Watt W. Webb — Jonas Korlach — and Harold Craighead — Steve Turner and Mathieu Foquet — became the first employees. It began under the name Nanofluidics, Inc. The company raised nearly in six rounds of primarily venture capital financing, making it one of the most cap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Horizon Europe
Horizon Europe is a seven-year European Union scientific research initiative to help develop a sustainable and livable society in Europe. It is the ninth of the Framework Programmes for Research and Technological Development (FP9), and the successor of the Horizon 2020 programme (FP8). The European Commission drafted and approved a plan for Horizon Europe to raise EU science spending levels by 50% over the years 2021–2027. Objectives Horizon Europe adopts five missions: #Adaptation to Climate Change: support at least 150 European regions and communities to become climate resilient by 2030 #Cancer: working with Europe's Beating Cancer Plan to improve the lives of more than 3 million people by 2030 through disease prevention, cure and solutions to live longer and better #Restore our Ocean and Waters by 2030 #100 Climate-Neutral and Smart Cities by 2030 #A Soil Deal for Europe: 100 living labs and lighthouses to lead the transition towards healthy soils by 2030 Budget In May 201 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
