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Ergosine
400px, Alpha- and beta-ergosine. Ergosines are ergoloid-like chemicals made by ''Claviceps purpurea ''Claviceps purpurea'' is an ergot fungus that grows on the ear (botany), ears of rye and related cereal and forage plants. Consumption of Cereal, grains or seeds contaminated with the survival structure of this fungus, the ergot sclerotium, can ...''. External links Incorporation of thiazolidine-4-carbozylic acid into ergosine by Claviceps purpurea Ergopeptines Ergot alkaloids Indolizidines Lactams {{alkaloid-stub ...
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Ergopeptines
Ergoline is a core structure in many alkaloids and their synthetic derivatives. Ergoline alkaloids were first characterized in ergot. Some of these are implicated in the condition of ergotism, which can take a convulsive form or a gangrenous form. Even so, many ergoline alkaloids have been found to be clinically useful. Annual world production of ergot alkaloids has been estimated at 5,000–8,000 kg of all ergopeptines and 10,000–15,000 kg of lysergic acid, used primarily in the manufacture of semi-synthetic derivatives. Others, such as lysergic acid diethylamide, better known as LSD, a semi-synthetic derivative, and ergine, a natural derivative found in '' Argyreia nervosa'', ''Ipomoea tricolor'' and related species, are known psychedelic substances. Natural occurrence Ergoline alkaloids are found in fungi such as Claviceps purpurea, Claviceps paspali, and the related Periglandula, which have a permanent, symbiotic bond with numerous flowering vines, most notably, ...
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Ergosine (alpha + Beta)
400px, Alpha- and beta-ergosine. Ergosines are ergoloid-like chemicals made by ''Claviceps purpurea ''Claviceps purpurea'' is an ergot fungus that grows on the ear (botany), ears of rye and related cereal and forage plants. Consumption of Cereal, grains or seeds contaminated with the survival structure of this fungus, the ergot sclerotium, can ...''. External links Incorporation of thiazolidine-4-carbozylic acid into ergosine by Claviceps purpurea Ergopeptines Ergot alkaloids Indolizidines Lactams {{alkaloid-stub ...
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Ergoloid
Ergoloid mesylates (USAN), co-dergocrine mesilate ( BAN) or dihydroergotoxine mesylate, trade name Hydergine, is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids ( dihydroergocristine, dihydroergocornine, and alpha- and beta-dihydroergocryptine). It was developed by Albert Hofmann (the discoverer of LSD) for Sandoz (now part of Novartis). Medical uses It has been used to treat dementia and age-related cognitive impairment (such as in Alzheimer disease), as well as to aid in recovery after stroke. A systematic review published in 1994 found little evidence to support the use of ergoloid mesylates, concluding only that potentially effective doses may be higher than those currently approved in dementia treatment. Ergoloid Mesylate Tablets USP for sublingual use contain 1 mg of Ergoloid Mesylates USP, a mixture of the methanesulfonate salt of the following hydrogenated alkaloids: Dihydroergocornine mesylate 0.333 mg, Dihydroergocristine ...
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Claviceps Purpurea
''Claviceps purpurea'' is an ergot fungus that grows on the ear (botany), ears of rye and related cereal and forage plants. Consumption of Cereal, grains or seeds contaminated with the survival structure of this fungus, the ergot sclerotium, can cause ergotism in humans and other mammals. ''C. purpurea'' most commonly affects Open pollination, outcrossing species such as rye (its most common host), as well as triticale, wheat and barley. It affects oats only rarely. Life cycle An ''ergot kernel'' called ''Sclerotium clavus'' develops when a floret of flowering grass or cereal is infected by an ascospore of ''C. purpurea''. The infection process mimics a pollen grain growing into an ovary (plants), ovary during fertilization. Because infection requires access of the fungal spore to the Gynoecium, stigma, plants infected by ''C. purpurea'' are mainly outcrossing species with Anemophily, open flowers, such as rye (''Secale, Secale cereale'') and Alopecurus. The proliferating fun ...
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Ergot Alkaloids
Ergot ( ) or ergot fungi refers to a group of fungus, fungi of the genus ''Claviceps''. The most prominent member of this group is ''Claviceps purpurea'' ("rye ergot fungus"). This fungus grows on rye and related plants, and produces alkaloids that can cause ergotism in humans and other mammals who consume grains contaminated with its fruiting structure (called ''ergot sclerotium''). ''Claviceps'' includes about 50 known species, mostly in the tropical regions. Economically significant species include ''C. purpurea'' (parasitic on Poaceae, grasses and cereals), ''C. fusiformis'' (on pearl millet, buffel grass), ''C. paspali'' (on dallis grass), ''C. africana'' (on sorghum) and ''C. lutea'' (on paspalum). ''C. purpurea'' most commonly affects Open pollination, outcrossing species such as rye (its most common host), as well as triticale, wheat and barley. It affects oats only rarely. ''C. purpurea'' has at least three races or varieties, which differ in their host specificity: *G ...
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