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Eliezer Masliah
Eliezer Masliah (born ) is a neuropathologist who was the director of the division of neuroscience at the National Institute on Aging from 2016 to 2024. In September 2024, an investigation exposed image manipulation across 132 of Masliah's research papers, raising concerns about data integrity in studies influencing Alzheimer's and Parkinson's disease treatments, pharmaceutical patents, and clinical trials. As of March 2025 he has 4 retractions. Background He received his medical degree in 1982 from the National Autonomous University of Mexico. After postdoctoral training at University of California, San Diego (UCSD) he became a tenure-track Professor at UCSD's Department of Neuroscience, with a joint appointment in Pathology. He also directed the neuropathology core of the Shirley-Marcos Alzheimer’s Disease Research Center at UCSD. He was appointed head of the U.S. National Institute on Aging's Division of Neuroscience in 2016. He has a prolific body of work — over 800 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eliezer Masliah-2016-FINAL For Blog
Eliezer () was the name of at least three different individuals in the Hebrew Bible. Eliezer of Damascus Eliezer of Damascus () was, according to Targum Jonathan Bereishit, 14:14, the son of Nimrod. As mentioned in Genesis 15:2, Eliezer was head of the patriarch Abraham's household. Medieval biblical exegetes have explained the noun ''ben mešeq'' as meaning "butler; steward; overseer", while the name ''Damméseq Eliʿézer'' is explained by Targum Onkelos as meaning "Eliezer the Damascene." Others say that he was given the name "Damascus" by Abraham, who purchased Eliezer from Nimrod and had passed through the city of Damascus while returning with his servant from Babylonia. Other translations of Genesis describe Eliezer as Abraham's heir. There is an interpretation in Genesis Rabbah (43:2), cited by Rashi, that Eliezer went alone with Abraham to rescue Lot, about "his initiates" stated to be 318 in number () being the numerical value of Eliezer's name in Hebrew, interpr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prasinezumab
Prasinezumab (, ; developmental code names NEOD002, PRX-002, RG-7935, RO-7046015) is an anti-α-synuclein drug acting as a monoclonal antibody against α-synuclein which is under development for the treatment of Parkinson's disease. No significant effect on disease progression was seen in a 52-week phase 2 clinical trial.There have been concerns about research misconduct and data fabrication relevant to prasinezumab. As of May 2024, prasinezumab is in phase 3 clinical trials for Parkinson's disease. It is under development by Prothena Biosciences and Roche. Mechanism of action Prasinezumab is a humanized IgG1 monoclonal antibody that selectively binds to aggregated forms of alpha-synuclein while sparing the physiological monomeric form. The antibody recognizes the C-terminus of α-synuclein and preferentially targets pathological aggregates that form insoluble fibrils and Lewy bodies—hallmark features of Parkinson's disease pathology. Development history Prasinezumab was or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People Involved In Scientific Misconduct Incidents
The term "the people" refers to the public or common mass of people of a polity. As such it is a concept of human rights law, international law as well as constitutional law, particularly used for claims of popular sovereignty. In contrast, a people is any plurality of persons considered as a whole. Used in politics and law, the term "a people" refers to the collective or community of an ethnic group or nation. Concepts Legal Chapter One, Article One of the Charter of the United Nations states that "peoples" have the right to self-determination. Though the mere status as peoples and the right to self-determination, as for example in the case of Indigenous peoples (''peoples'', as in all groups of indigenous people, not merely all indigenous persons as in ''indigenous people''), does not automatically provide for independent sovereignty and therefore secession. Indeed, judge Ivor Jennings identified the inherent problems in the right of "peoples" to self-determination, as i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1950s Births
Year 195 ( CXCV) was a common year starting on Wednesday of the Julian calendar. At the time, it was known in Rome as the Year of the Consulship of Scrapula and Clemens (or, less frequently, year 948 ''Ab urbe condita''). The denomination 195 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Emperor Septimius Severus has the Roman Senate deify the previous emperor Commodus, in an attempt to gain favor with the family of Marcus Aurelius. * King Vologases V and other eastern princes support the claims of Pescennius Niger. The Roman province of Mesopotamia rises in revolt with Parthian support. Severus marches to Mesopotamia to battle the Parthians. * The Roman province of Syria is divided and the role of Antioch is diminished. The Romans annex the Syrian cities of Edessa and Nisibis. Severus re-establishes his headquarters and the colonies th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Neuroscientists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports teams S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Minzasolmin
Minzasolmin (development names DLX313 and UCB0599) is an experimental small-molecule drug in development for Parkinson's disease that is designed to prevent misfolding of α-synuclein. See also * Anti-α-synuclein drug An anti-α-synuclein drug, or an α-synuclein inhibitor, is a drug which blocks or inhibits α-synuclein. α-Synuclein is a protein which is thought to be involved in the development and progression of α-synucleinopathies including Parkinson's d ... References {{reflist Experimental drugs Small-molecule drugs Parkinson's disease Indoles Thiazoles 4-Methylpiperazin-1-yl compounds Carboxamides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebrolysin
Cerebrolysin (developmental code name FPF-1070) is an experimental mixture of enzymatically-treated peptides derived from pig brain whose constituents can include brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF). Although it is under preliminary study for its potential to treat various brain diseases, it is used as a therapy in dozens of countries in Eurasia. Cerebrolysin has been studied for potential treatment of several neurodegenerative diseases, with only preliminary research, as of 2023. No clear benefit in the treatment of acute stroke has been found, and an increased rate of spontaneous adverse effects requiring hospitalization is reported. Some positive effects have been reported when cerebrolysin is used to treat vascular dementia. Research Stroke A 2023 review indicated that cerebrolysin or cerebrolysin-like peptide mixtures from cattle brain likely provide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synucleinopathy
Synucleinopathies (also called α-Synucleinopathies) are neurodegenerative diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. There are three main types of synucleinopathy: Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Other rare disorders, such as various neuroaxonal dystrophies, also have α-synuclein pathologies. Additionally, autopsy studies have shown that around 6% of sporadic Alzheimer's Disease exhibit α-synuclein positive Lewy pathology, and are sub-classed as Alzheimer's Disease with Amygdalar Restricted Lewy Bodies (AD/ALB). Presentation The synucleinopathies have shared features of parkinsonism, impaired cognition, sleep disorders, and visual hallucinations. Synucleinopathies can sometimes overlap with tauopathies, possibly because of interaction between the synuclein and tau proteins. REM sleep behavior disorder (RBD) is a parasomnia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HHS Office Of Research Integrity
The Office of Research Integrity (ORI) is a U.S. government agency that focuses on research integrity, especially in health. It was created when the Office of Scientific Integrity (OSI) in the National Institutes of Health (NIH) and the Office of Scientific Integrity Review (OSIR) in the Office of the Assistant Secretary for Health merged in May 1992. The Office of Research Integrity oversees and directs Public Health Service (PHS) research integrity activities on behalf of the Secretary of Health and Human Services, except for the regulatory research integrity activities of the Food and Drug Administration. Organizationally, ORI is located within the Office of the Assistant Secretary for Health (OASH) within the Office of the Secretary of Health and Human Services (OS), in the Department of Health and Human Services (HHS). Activities ORI carries out its responsibility by: * Developing policies, procedures and regulations related to the detection, investigation, and prevention of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuropathologist
Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies. Neuropathologists usually work in a department of anatomic pathology, but work closely with the clinical disciplines of neurology, and neurosurgery, which often depend on neuropathology for a diagnosis. Neuropathology also relates to forensic pathology because brain disease or brain injury can be related to cause of death. Neuropathology should not be confused with neuropathy, which refers to disorders of the nerves themselves (usually in the peripheral nervous system) rather than the tissues. In neuropathology, the branches of the specializations of nervous system as well as the tissues come together into one field of study. Methodology The work of the neuropathologist consists largely of examining autopsy or biopsy tissue from the brain and spinal cord to aid in diagnosis of disease. In addition to brain and spinal cord, tissues of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-synuclein
Alpha-synuclein (aSyn) is a protein that in humans is encoded by the ''SNCA'' gene. It is a neuronal protein involved in the regulation of synaptic vesicle trafficking and the release of neurotransmitters. Alpha-synuclein is abundant in the brain, with smaller amounts present in the heart, muscles, and other tissues. Within the brain, it is primarily localized to the axon terminals of presynaptic neurons. There, it interacts with phospholipids and other proteins. Presynaptic terminals release neurotransmitters from specialized compartments called synaptic vesicles, a process essential for neuronal communication and normal brain function. In Parkinson's disease and related synucleinopathies, abnormal, insoluble forms of alpha-synuclein accumulate within neurons as inclusion bodies, inclusions known as Lewy body, Lewy bodies. Mutations in the ''SNCA'' gene are linked to familial forms of Parkinson's disease. During the process of seeded nucleation, alpha-synuclein adopts a cross-be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
