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Dsup
Dsup (contraction of ''damage suppressor'') is a DNA-associating protein, unique to the tardigrade, that suppresses the occurrence of DNA breaks by radiation. When human HEK293 cells were engineered with Dsup proteins, they showed approximately 40% more tolerance against X-ray radiation. Tardigrades can withstand 1,000 times more radiation than other animals, median lethal doses of 5,000 Gy (of gamma rays) and 6,200 Gy (of heavy ions) in hydrated animals (5 to 10 Gy could be fatal to a human). The only explanation found in earlier experiments for this ability was that their lowered water state provides fewer reactants for ionizing radiation. However, subsequent research found that tardigrades, when hydrated, still remain highly resistant to shortwave UV radiation in comparison to other animals, and that one factor for this is their ability to efficiently repair damage to their DNA resulting from that exposure. A landmark study on Dsup protein showed that it can bind nucleosomes i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tardigrade
Tardigrades (), known colloquially as water bears or moss piglets, are a phylum of eight-legged segmented micro-animals. They were first described by the German zoologist Johann August Ephraim Goeze in 1773, who called them Kleiner Wasserbär ("little water bear"). In 1777, the Italian biologist Lazzaro Spallanzani named them Tardigrada (), which means "slow steppers". They have been found in diverse regions of Earth's biospheremountaintops, the deep sea, tropical rainforests, and the Antarctic. Tardigrades are among the most resilient animals known, with individual species able to survive extreme conditions – such as exposure to extreme temperatures, extreme pressures (both high and low), air deprivation, radiation, dehydration, and starvation – that would quickly kill most other known forms of life. Tardigrades have survived exposure to outer space. There are about 1,300 known species in the phylum Tardigrada, a part of the superphylum Ecdysozoa consisting of ani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vice (magazine)
''Vice'' (stylized in all caps) is a Canadian-American magazine focused on lifestyle, arts, culture, and news/politics. Founded in 1994 in Montreal as an alternative punk magazine, the founders later launched the youth media company Vice Media, which consists of divisions including the printed magazine as well as a website, broadcast news unit, a film production company, a record label, and a publishing imprint. As of February 2015, the magazine's editor-in-chief is Ellis Jones. History Founded by Suroosh Alvi, Gavin McInnes, and Shane Smith (the latter two being childhood friends), the magazine was launched in 1994 as the ''Voice of Montreal'' with government funding. The intention of the founders was to provide work and a community service. When the editors later sought to dissolve their commitments with the original publisher, Alix Laurent, they bought him out and changed the name to ''Vice'' in 1996. Richard Szalwinski, a Canadian software millionaire, acquired the ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gray (unit)
The gray (symbol: Gy) is the unit of ionizing radiation dose in the International System of Units (SI), defined as the absorption of one joule of radiation energy per kilogram of matter. It is used as a unit of the radiation quantity absorbed dose that measures the energy deposited by ionizing radiation in a unit mass of matter being irradiated, and is used for measuring the delivered dose in radiotherapy, food irradiation and radiation sterilization. It is important in predicting likely acute health effects, such as acute radiation syndrome and is used to calculate equivalent dose using the sievert, which is a measure of the stochastic health effect on the human body. The gray is also used in radiation metrology as a unit of the radiation quantity kerma; defined as the sum of the initial kinetic energies of all the charged particles liberated by uncharged ionizing radiation in a sample of matter per unit mass. The gray is an important unit in ionising radiation measurem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ionizing Radiation
Ionizing radiation (or ionising radiation), including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them. Some particles can travel up to 99% of the speed of light, and the electromagnetic waves are on the high-energy portion of the electromagnetic spectrum. Gamma rays, X-rays, and the higher energy ultraviolet part of the electromagnetic spectrum are ionizing radiation, whereas the lower energy ultraviolet, visible light, nearly all types of laser light, infrared, microwaves, and radio waves are non-ionizing radiation. The boundary between ionizing and non-ionizing radiation in the ultraviolet area is not sharply defined, as different molecules and atoms ionize at different energies. The energy of ionizing radiation starts between 10 electronvolts (eV) and 33 eV. Typical ionizing subatomic particles include alpha particles, beta particles, and neutrons. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UV Radiation
Ultraviolet (UV) is a form of electromagnetic radiation with wavelength from 10 nm (with a corresponding frequency around 30 PHz) to 400 nm (750 THz), shorter than that of visible light, but longer than X-rays. UV radiation is present in sunlight, and constitutes about 10% of the total electromagnetic radiation output from the Sun. It is also produced by electric arcs and specialized lights, such as mercury-vapor lamps, tanning lamps, and black lights. Although long-wavelength ultraviolet is not considered an ionizing radiation because its photons lack the energy to ionize atoms, it can cause chemical reactions and causes many substances to glow or fluoresce. Consequently, the chemical and biological effects of UV are greater than simple heating effects, and many practical applications of UV radiation derive from its interactions with organic molecules. Short-wave ultraviolet light damages DNA and sterilizes surfaces with which it comes into contact. For h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ramazzottius
''Ramazzottius'' is a genus of water bear or moss piglet, a tardigrade in the class Eutardigrada Eutardigrada are a class of tardigrades (Tardigrada) without lateral appendices. Primarily freshwater bound, some species have secondarily gained the ability to live in marine environments (''Halobiotus''). By cryptobiosis many species are able t .... Species * '' Ramazzottius affinis'' Bertolani, Guidetti and Rebecchi, 1993 * '' Ramazzottius andreevi'' Biserov, 1998 * '' Ramazzottius anomalus'' Ramazzotti, 1962) * '' Ramazzottius baumanni'' Ramazzotti, 1962) * '' Ramazzottius bunikowskae'' Kaczmarek, Michalczyk and Diduszko, 2006 * '' Ramazzottius cataphractus'' Maucci, 1974) * '' Ramazzottius caucasicus'' Biserov, 1998 * '' Ramazzottius edmondabouti'' Séméria, 1993 * '' Ramazzottius horningi'' Binda and Pilato, 1995 * '' Ramazzottius ljudmilae'' Biserov, 1998 * '' Ramazzottius montivagus'' Dastych, 1983) * '' Ramazzottius novemcinctus'' Marcus, 1936) * '' Ramazzottius oberhaeuse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypsibius Exemplaris
''Hypsibius dujardini sensu lato'' is a species complex of tardigrade in the class Eutardigrada Eutardigrada are a class of tardigrades (Tardigrada) without lateral appendices. Primarily freshwater bound, some species have secondarily gained the ability to live in marine environments (''Halobiotus''). By cryptobiosis many species are able t .... A member of this complex, ''Hypsibius exemplaris'', is widely used for various research projects pertaining to evolutionary biology and astrobiology. ''H. exemplaris'' was differentiated from ''H. dujardini sensu stricto'' in 2018. Earlier studies refer to this lab species from northwest England as ''H. dujardini''. ''H. dujardini s.s.'' is found in France, and has differences in 18S rRNA sequence and morphological details. Habitat The species, ''Hypsibius dujardini'', is a tardigrade that prefers freshwater lakes, rivers, and streams. Because they are considered cosmopolitan, their geographical range is immense. They can be found ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleosomes
A nucleosome is the basic structural unit of DNA packaging in eukaryotes. The structure of a nucleosome consists of a segment of DNA wound around eight histone proteins and resembles thread wrapped around a spool. The nucleosome is the fundamental subunit of chromatin. Each nucleosome is composed of a little less than two turns of DNA wrapped around a set of eight proteins called histones, which are known as a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. DNA must be compacted into nucleosomes to fit within the cell nucleus. In addition to nucleosome wrapping, eukaryotic chromatin is further compacted by being folded into a series of more complex structures, eventually forming a chromosome. Each human cell contains about 30 million nucleosomes. Nucleosomes are thought to carry epigenetically inherited information in the form of covalent modifications of their core histones. Nucleosome positions in the gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HMGN
HMGN (High Mobility Group Nucleosome-binding) proteins are members of the broader class of high mobility group (HMG) chromosomal proteins that are involved in regulation of Transcription (biology), transcription, DNA replication, replication, Genetic recombination, recombination, and DNA repair. HMGN1 and HMGN2 (initially designated HMG-14 and HMG-17 respectively) were discovered by E.W. Johns research group in the early 1970s. HMGN3, HMGN4, and HMGN5 were discovered later and are less abundant. HMGNs are nucleosome binding proteins that help in transcription, replication, recombination, and DNA repair. They can also alter the chromatin epigenetic landscape, helping to stabilize cell identity. There is still relatively little known about their structure and function. HMGN proteins are found in all vertebrates, and play a role in chromatin structure and histone modification. HMGNs come in long chains of amino acids, containing around 100 for HMGN1-4, and roughly 200 in HMGN5. Rec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Dynamic
A molecule is a group of two or more atoms held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions which satisfy this criterion. In quantum physics, organic chemistry, and biochemistry, the distinction from ions is dropped and ''molecule'' is often used when referring to polyatomic ions. A molecule may be homonuclear, that is, it consists of atoms of one chemical element, e.g. two atoms in the oxygen molecule (O2); or it may be heteronuclear, a chemical compound composed of more than one element, e.g. water (two hydrogen atoms and one oxygen atom; H2O). In the kinetic theory of gases, the term ''molecule'' is often used for any gaseous particle regardless of its composition. This relaxes the requirement that a molecule contains two or more atoms, since the noble gases are individual atoms. Atoms and complexes connected by non-covalent interactions, such as hydrogen bonds or ionic bonds, are typically not consid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intrinsically Disordered Protein
In molecular biology, an intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure, typically in the absence of its macromolecular interaction partners, such as other proteins or RNA. IDPs range from fully unstructured to partially structured and include random coil, molten globule-like aggregates, or flexible linkers in large multi-domain proteins. They are sometimes considered as a separate class of proteins along with globular, fibrous and membrane proteins. IDPs are a very large and functionally important class of proteins and their discovery has disproved the idea that three-dimensional structures of proteins must be fixed to accomplish their biological functions. For example, IDPs have been identified to participate in weak multivalent interactions that are highly cooperative and dynamic, lending them importance in DNA regulation and in cell signaling. Many IDPs can also adopt a fixed three-dimensional structure after ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
