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Dmitry Gabrilovich
Dmitry Gabrilovich is currently a Chief Scientist, Cancer Immunology at AstraZeneca in Gaithersburg, MD, USA. His research is focused on methods by which tumors are able to suppress the immune system and how to develop new immune therapies to combat this ability. Gabrilovich described the defective ability of dendritic cells in induce immune responses in cancer, and was one of the discoverers of myeloid-derived suppressor cells (MDSC). The Gabrilovich lab focuses on immature myeloid cell biology and its relation to cancer. MDSC have been linked to a number of signaling pathways associated with cancer, including NF-κB, Jak-STAT, Notch, Wnt, and Rb, among others. His research has found that tumor cells can go through a mechanism that produces a free radical peroxynitrite, causing them to become resistant to certain types of cancer immunotherapy. His research has also focused on monocytic-myeloid derived suppressor cells and polymorphonuclear-myeloid derived suppressor cells and what ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Minsk, USSR
Minsk ( be, Мінск ; russian: Минск) is the capital and the largest city of Belarus, located on the Svislach (Berezina), Svislach and the now subterranean Nyamiha, Niamiha rivers. As the capital, Minsk has a special administrative status in Belarus and is the administrative centre of Minsk Region (oblast, voblast) and Minsk District (Raion, raion). As of January 2021, its population was 2 million, making Minsk the Largest cities in Europe, 11th most populous city in Europe. Minsk is one of the administrative capitals of the Commonwealth of Independent States (CIS) and the Eurasian Economic Union (EAEU). First documented in 1067, Minsk became the capital of the Principality of Minsk before being annexed by the Grand Duchy of Lithuania in 1242. It received town privileges in 1499. From 1569, it was the capital of the Minsk Voivodeship, an administrative division of the Polish–Lithuanian Commonwealth. It was part of a region annexed by the Russian Empire in 1793, as a c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumors
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, when it may be called a tumor. ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word is from Ancient Greek 'new' and 'formation, creation'. Types A neoplasm can be benign, potentially ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myeloid-derived Suppressor Cell
Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage (a family of cells that originate from bone marrow stem cells). MDSCs expand under pathologic conditions such as chronic infection and cancer, as a result of altered haematopoiesis. MDSCs differ from other myeloid cell types in that they have immunosuppressive activities, as opposed to immune-stimulatory properties. Similar to other myeloid cells, MDSCs interact with immune cell types such as T cells, dendritic cells, macrophages and natural killer cells to regulate their functions. Tumors with high levels of infiltration by MDSCs have been associated with poor patient outcome and resistance to therapies. MDSCs can also be detected in the blood. In patients with breast cancer, levels of MDSC in blood are about 10-fold higher than normal. The size of the myeloid suppressor compartment is considered to be an important factor in the success or failure of cancer immunotherapy, h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myeloid
Myeloid tissue, in the bone marrow sense of the word ''myeloid'' ('' myelo-'' + '' -oid''), is tissue of bone marrow, of bone marrow cell lineage, or resembling bone marrow, and myelogenous tissue (''myelo-'' + '' -genous'') is any tissue of, or arising from, bone marrow; in these senses the terms are usually used synonymously, as for example with chronic myeloid/myelogenous leukemia. In hematopoiesis, myeloid or myelogenous cells are blood cells that arise from a progenitor cell for granulocytes, monocytes, erythrocytes, or platelets (the common myeloid progenitor, that is, CMP or CFU-GEMM), or in a narrower sense also often used, specifically from the lineage of the myeloblast (the myelocytes, monocytes, and their daughter types). Thus, although all blood cells, even lymphocytes, are normally born in the bone marrow in adults, myeloid cells in the narrowest sense of the term can be distinguished from lymphoid cells, that is, lymphocytes, which come from common ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunopharmacology
Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there is a difference of human immunology and comparative immunology in veterinary medicine and animal biosciences. Immunology measures, uses charts and differentiate in context in medicine the studies of immunity on cell and molecular level, and the immune system as part of the physiological level as its functioning is of major importance. In the different states of both health, occurring symptoms and diseases; the functioning of the immune system and immunological responses such as autoimmune diseases, allergic hypersensitivities, or in some cases malfunctioning of immune system as for example in immunological disorders or in immune deficiency, and the specific transplant rejection) Immunology has applications in numerous disciplines of med ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science Daily
''Science Daily'' is an American website launched in 1995 that aggregates press releases and publishes lightly edited press releases (a practice called churnalism) about science, similar to Phys.org and EurekAlert!. The site was founded by married couple Dan and Michele Hogan in 1995; Dan Hogan formerly worked in the public affairs department of Jackson Laboratory The Jackson Laboratory (often abbreviated as JAX) is an independent, non-profit biomedical research institution which was founded by a eugenicist. It employs more than 3,000 employees in Bar Harbor, Maine; Sacramento, California; Farmington, Con ... writing press releases. The site makes money from selling advertisements. As of 2010, the site said that it had grown "from a two-person operation to a full-fledged news business with worldwide contributors". At the time, it was run out of the Hogans' home, had no reporters, and only reprinted press releases. In 2012, Quantcast ranked it at 614 with 2.6 million U.S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Asia
Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are part of nature, human activity is often understood as a separate category from other natural phenomena. The word ''nature'' is borrowed from the Old French ''nature'' and is derived from the Latin word ''natura'', or "essential qualities, innate disposition", and in ancient times, literally meant "birth". In ancient philosophy, ''natura'' is mostly used as the Latin translation of the Greek word ''physis'' (φύσις), which originally related to the intrinsic characteristics of plants, animals, and other features of the world to develop of their own accord. The concept of nature as a whole, the physical universe, is one of several expansions of the original notion; it began with certain core applications of the word φύσις by pre-Socr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Wistar Institute
The Wistar Institute () is an independent, nonprofit research institution in biomedical science, with expertise in oncology, immunology, infectious disease and vaccine research. Located on the campus of the University of Pennsylvania, Wistar was founded in 1892 as America's first nonprofit institution solely focused on biomedical research and training. The institute ties with the university, reflected in research collaboration and shared access to facilities. Since 1972, Wistar has been a National Cancer Institute (NCI)-designated cancer center. It has received the highest rating of "exceptional" in two consecutive terms in 2013 and 2018 by the Cancer Center Support Grant. Known worldwide for vaccine development, some of the institute's accomplishments are its contributions to the creation of vaccines for rubella (German Measles), rotavirus and rabies. Research Cancer research Working at The Wistar Institute Cancer Center spans from basic to translational and disease-relevant c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philadelphia
Philadelphia, often called Philly, is the largest city in the Commonwealth of Pennsylvania, the sixth-largest city in the U.S., the second-largest city in both the Northeast megalopolis and Mid-Atlantic regions after New York City. Since 1854, the city has been coextensive with Philadelphia County, the most populous county in Pennsylvania and the urban core of the Delaware Valley, the nation's seventh-largest and one of world's largest metropolitan regions, with 6.245 million residents . The city's population at the 2020 census was 1,603,797, and over 56 million people live within of Philadelphia. Philadelphia was founded in 1682 by William Penn, an English Quaker. The city served as capital of the Pennsylvania Colony during the British colonial era and went on to play a historic and vital role as the central meeting place for the nation's founding fathers whose plans and actions in Philadelphia ultimately inspired the American Revolution and the nation's inde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Vaccine Institute
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, sedentary lifestyle, lack of physical activity or Alcohol abuse, excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the Developing country, developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and HIV, human immunodeficiency virus (HIV). These factor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moffitt Cancer Center
Houston Lee Moffitt Cancer Center & Research Institute is a nonprofit cancer treatment and research center located in Tampa, Florida. Established in 1981 by the Florida Legislature, the hospital opened in October 1986 on the University of South Florida's campus. Moffitt is one of two National Cancer Institute-designated Comprehensive Cancer Centers based in Florida. In 2021, '' U.S. News & World Report'' ranked Moffitt Cancer Center as a top 30 cancer hospital in the United States. History Funding for construction of the initial $70 million facility came primarily from the state of Florida's cigarette tax, while the momentum to create the center came from a cadre of legislators, physicians, educators, and business leaders who envisioned a new dimension of cancer care and research in Florida. In late 1978, H. Lee Moffitt, a Florida state representative, recognized the need for a comprehensive cancer center within the state after several friends died from cancer. An excellent neg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tampa
Tampa () is a city on the Gulf Coast of the U.S. state of Florida. The city's borders include the north shore of Tampa Bay and the east shore of Old Tampa Bay. Tampa is the largest city in the Tampa Bay area and the seat of Hillsborough County. With a population of 384,959 according to the 2020 census, Tampa is the third-most populated city in Florida after Jacksonville and Miami and is the 52nd most populated city in the United States. Tampa functioned as a military center during the 19th century with the establishment of Fort Brooke. The cigar industry was also brought to the city by Vincente Martinez Ybor, after whom Ybor City is named. Tampa was formally reincorporated as a city in 1887, following the Civil War. Today, Tampa's economy is driven by tourism, health care, finance, insurance, technology, construction, and the maritime industry. The bay's port is the largest in the state, responsible for over $15 billion in economic impact. The city is part of the Tamp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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