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Diphtheria Antitoxin
Diphtheria antitoxin (DAT) is a medication made up of antibodies used in the treatment of diphtheria. It is no longer recommended for prevention of diphtheria. It is administered through injection into a vein or muscle. Side effects are common. They include serum sickness and allergic reactions including anaphylaxis. Diphtheria antitoxin is made from the blood plasma of horses that have been immunized against diphtheria toxin. It works by neutralizing the toxins produced by ''Corynebacterium diphtheriae''. Diphtheria antitoxin was developed and came into medical use in the late 1800s. The 1901 diphtheria antitoxin contamination incident, in which the milk wagon horse used to culture the antitoxin became infected with tetanus, which contaminated vials of the antitoxin leading to the deaths of several children in the midwest United States, led to the passage of the Biologics Control Act of 1902 and the 1906 formation of the U.S. Food and Drug Administration (FDA). The cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intramuscular
Intramuscular injection, often abbreviated IM, is the injection of a substance into a muscle. In medicine, it is one of several methods for parenteral administration of medications. Intramuscular injection may be preferred because muscles have larger and more numerous blood vessels than subcutaneous tissue, leading to faster absorption than subcutaneous or intradermal injections. Medication administered via intramuscular injection is not subject to the first-pass metabolism effect which affects oral medications. Common sites for intramuscular injections include the deltoid muscle of the upper arm and the gluteal muscle of the buttock. In infants, the vastus lateralis muscle of the thigh is commonly used. The injection site must be cleaned before administering the injection, and the injection is then administered in a fast, darting motion to decrease the discomfort to the individual. The volume to be injected in the muscle is usually limited to 2–5 milliliters, depending ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C). However, the agency also enforces other laws, notably Section 361 of the Public Health Service Act as well as associated regulations. Much of this regulatory-enforcement work is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diphtheria
Diphtheria is an infection caused by the bacteria, bacterium ''Corynebacterium diphtheriae''. Most infections are asymptomatic or have a mild Course (medicine), clinical course, but in some outbreaks, the mortality rate approaches 10%. Signs and symptoms may vary from mild to severe, and usually start two to five days after exposure. Symptoms often develop gradually, beginning with a sore throat and fever. In severe cases, a grey or white patch develops in the throat, which can block the airway, and create a barking cough similar to what is observed in croup. The neck may also swell, in part due to the enlargement of the facial lymph nodes. Diphtheria can also involve the skin, eyes, or genitals, and can cause complications, including myocarditis (which in itself can result in an cardiac arrhythmia, abnormal heart rate), peripheral neuropathy, inflammation of nerves (which can result in paralysis), proteinuria, kidney problems, and bleeding problems due to thrombocytopenia, low ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Globulins
The globulins are a family of globular proteins that have higher molecular weights than albumins and are insoluble in pure water but dissolve in dilute salt solutions. Some globulins are produced in the liver, while others are made by the immune system. Globulins, albumins, and fibrinogen are the major blood proteins. The normal concentration of globulins in human blood is about 2.6-3.5 g/dL. The term "globulin" is sometimes used synonymously with "globular protein". However, albumins are also globular proteins, but are ''not'' globulins. All other serum globular proteins are globulins. Types of globulin All globulins fall into one of three categories: * Alpha globulins * Beta globulins * Gamma globulins (one group of gamma globulins is the immunoglobulins, which are also known as "antibodies") Globulins can be distinguished from one another using serum protein electrophoresis. Globulins exert oncotic pressure. Their deficiency results in loss of carrier functions of g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antitoxin Diphtheria
An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants, and bacteria in response to toxin exposure. Although they are most effective in neutralizing toxins, they can also kill bacteria and other microorganisms. Antitoxins are made within organisms, and can be injected into other organisms, including humans, to treat an infectious disease. This procedure involves injecting an animal with a safe amount of a particular toxin. The animal's body then makes the antitoxin needed to neutralize the toxin. Later, blood is withdrawn from the animal. When the antitoxin is obtained from the blood, it is purified and injected into a human or other animal, inducing temporary passive immunity. To prevent serum sickness, it is often best to use an antitoxin obtained from the same species (e.g. use human antitoxin to treat humans). Most antitoxin preparations are prepared from donors with high titers of antibody against th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Europe
Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere. It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, the Mediterranean Sea to the south, and Asia to the east. Europe shares the landmass of Eurasia with Asia, and of Afro-Eurasia with both Africa and Asia. Europe is commonly considered to be Boundaries between the continents#Asia and Europe, separated from Asia by the Drainage divide, watershed of the Ural Mountains, the Ural (river), Ural River, the Caspian Sea, the Greater Caucasus, the Black Sea, and the waterway of the Bosporus, Bosporus Strait. "Europe" (pp. 68–69); "Asia" (pp. 90–91): "A commonly accepted division between Asia and Europe ... is formed by the Ural Mountains, Ural River, Caspian Sea, Caucasus Mountains, and the Black Sea with its outlets, the Bosporus and Dardanelles." Europe covers approx. , or 2% of Earth#Surface, Earth's surface (6.8% of Earth's land area), making it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Centers For Disease Control
The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency under the Department of Health and Human Services (HHS), and is headquartered in Atlanta, Georgia. The CDC's current nominee for director is Susan Monarez. She became acting director on January 23, 2025, but stepped down on March 24, 2025 when nominated for the director position. On May 14, 2025, Robert F. Kennedy Jr. stated that lawyer Matthew Buzzelli is acting CDC director. However, the CDC web site does not state the acting director's name. The agency's main goal is the protection of public health and safety through the control and prevention of disease, injury, and disability in the US and worldwide. The CDC focuses national attention on developing and applying disease control and prevention. It especially focuses its attention on infectious disease, Foodborne illness, food borne pathogens, environmental health, occupat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WHO Model List Of Essential Medicines
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. The list is frequently used by countries to help develop their own local lists of essential medicines. , more than 155 countries have created national lists of essential medicines based on the World Health Organization's model list. This includes both Developed country, developed and Developing country, developing countries. The list is divided into core items and complementary items. The core items are deemed to be the most cost-effective options for key health problems and are usable with little additional health care resources. The complementary items either require additional infrastructure such as specially trained health care providers or diagnostic equipment or have a lower cost–benefit ratio. About 25% of items are in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nome, Alaska
Nome (; , , also ''Sitŋazuaq'', ''Siqnazuaq'') is a city in the Nome Census Area, Alaska, Nome Census Area in the Unorganized Borough, Alaska, Unorganized Borough of the US state of Alaska. The city is located on the southern Seward Peninsula coast on Norton Sound of the Bering Sea. It had a population of 3,699 in 2020, up from 3,598 in 2010. Nome was incorporation (municipal government), incorporated on April 9, 1901. It was once the most-populous city in Alaska. Nome lies within the region of the Bering Straits Native Corporation, which is headquartered in Nome. Prior to being settled by non-indigenous people, the area around Nome was home to Iñupiat natives. The area came to world attention in 1898, when three Nordic-Americans discovered gold on the ocean shores of Nome, prompting the Nome Gold Rush. Within a year, the area became popular among miners of European descent, who built and incorporated the city. Nome quickly reached a population of 10,000 or greater. Gold mining ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alaska Territory
The Territory of Alaska or Alaska Territory was an organized incorporated territory of the United States from August 24, 1912, until Alaska was granted statehood on January 3, 1959. The territory was previously Russian America, 1784–1867; the Department of Alaska, 1867–1884; and the District of Alaska, 1884–1912. Origin Passage of the 1899 Criminal Code which, among other things, included a tax on liquor, led to increased calls for Alaskan representation in Congress, and the debate finally ended on August 24, 1912, when the Alaska District became an organized, incorporated territory of the United States. The ''Second Organic Act of 1912'' renamed the District to the Territory of Alaska. By 1916, its population was about 58,000. James Wickersham, a Delegate to Congress, introduced Alaska's first statehood bill, but it failed for lack of interest from Alaskans. Even President Warren G. Harding's unprecedented visit in 1923 (just days before his death) could not cre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dog Sled
A dog sled or dog sleigh is a sled pulled by one or more sled dogs used to travel over ice and through snow, a practice known as mushing. Numerous types of sleds are used, depending on their function. They can be used for Sled dog racing, dog sled racing. Traditionally in Greenland and the eastern Canadian Arctic the Inuit had the dogs pull in a fan shape in front of the sled, while in other regions, such as Alaska and the western part of Northern Canada the dogs pull side by side in pairs. History Dog power has been used by humans for hunting and traveling for over 9,000 years. While dog sledding is an ancient tradition, it remains a crucial practice for remote communities that depend on it both culturally and economically, such as Qaanaaq and Ittoqqortoormiit, remote settlements in Greenland. With sea ice surrounding these areas for nine months each year, mushing is a skill passed down from a young age. Sled dogs continue to play a vital role as hunting and fishing companions, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1925 Serum Run To Nome
The 1925 serum run to Nome, also known as the Great Race of Mercy and The Serum Run, was a transport of diphtheria antitoxin by dog sled relay across the territory of Alaska, US territory of Alaska by 20 mushing, mushers and about 150 sled dogs across in 5½ days, saving the small town of Nome, Alaska, Nome and the surrounding communities from a developing epidemic of diphtheria. Both the mushers and their dogs were portrayed as heroes in the newly popular medium of radio and received headline coverage in newspapers across the United States. Balto, the lead sled dog on the final stretch into Nome, became the most famous List of individual dogs, canine celebrity of the era after Rin Tin Tin, and Statue of Balto, his statue is a popular tourist attraction in both New York City's Central Park and downtown Anchorage, Alaska. Togo (dog), Togo's team covered much of the most dangerous parts of the route and ran the farthest: Togo's team covered while Balto's team ran . Location and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
