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David W. Green (biochemist)
David W. Green ( - 1976) was a crystallographer at the Medical Research Council Unit for the Study of the Molecular Structure of Biological Systems, Cavendish Laboratory, University of Cambridge. David W. Green was a graduate student in the laboratory of Max Perutz at the University of Cambridge from 1952 to 1955 and obtained a Ph.D. He is known for demonstrating the first use of isomorphous replacement to solve the phase problem in X-ray crystallography. After completing his Ph.D., Green moved to the Davy-Faraday Research Laboratory at The Royal Institution in autumn 1955. He was recruited by Linus Pauling but ultimately moved to MIT to work with Alexander Rich. With Rich, Green solved the structure of N-methyluracil. After his postdoctoral work, he returned to the Davy-Faraday Research Laboratory at The Royal Institution in London, England to continue his crystallographic research. Later he moved to the Department of Physics at the University of Edinburgh The Un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Research Council (United Kingdom)
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy. The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date. History The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a conseq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cavendish Laboratory
The Cavendish Laboratory is the Department of Physics at the University of Cambridge, and is part of the School of Physical Sciences. The laboratory was opened in 1874 on the New Museums Site as a laboratory for experimental physics and is named after the British chemist and physicist Henry Cavendish. The laboratory has had a huge influence on research in the disciplines of physics and biology. The laboratory moved to its present site in West Cambridge in 1974. , 30 Cavendish researchers have won Nobel Prizes. Notable discoveries to have occurred at the Cavendish Laboratory include the discovery of the electron, neutron, and structure of DNA. Founding The Cavendish Laboratory was initially located on the New Museums Site, Free School Lane, in the centre of Cambridge. It is named after British chemist and physicist Henry Cavendish for contributions to science and his relative William Cavendish, 7th Duke of Devonshire, who served as chancellor of the university and donated fu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Cambridge
The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, world's third-oldest university in continuous operation. The university's founding followed the arrival of scholars who left the University of Oxford for Cambridge after a dispute with local townspeople. The two ancient university, ancient English universities, although sometimes described as rivals, share many common features and are often jointly referred to as Oxbridge. In 1231, 22 years after its founding, the university was recognised with a royal charter, granted by Henry III of England, King Henry III. The University of Cambridge includes colleges of the University of Cambridge, 31 semi-autonomous constituent colleges and List of institutions of the University of Cambridge#Schools, Faculties, and Departments, over 150 academic departm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Perutz
Max Ferdinand Perutz (19 May 1914 – 6 February 2002) was an Austrian-born British molecular biologist, who shared the 1962 Nobel Prize for Chemistry with John Kendrew, for their studies of the structures of haemoglobin and myoglobin. He went on to win the Royal Medal of the Royal Society in 1971 and the Copley Medal in 1979. At Cambridge he founded and chaired (1962–79) The MRC Laboratory of Molecular Biology (LMB), fourteen of whose scientists have won Nobel Prizes. Early life and education Perutz was born in Vienna, the son of Adele "Dely" (Goldschmidt) and Hugo Perutz, a textile manufacturer. His parents were Jewish by ancestry, but had baptised Perutz in the Catholic religion. Although Perutz rejected religion and was an atheist in his later years, he was against offending others for their religious beliefs. His parents hoped that he would become a lawyer, but he became interested in chemistry while at school. Overcoming his parents' objections he enrolled as a chemi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isomorphous Replacement
Isomorphous replacement (IR) is historically the most common approach to solving the phase problem in X-ray crystallography studies of proteins. For protein crystals this method is conducted by soaking the crystal of a sample to be analyzed with a heavy atom solution or co-crystallization with the heavy atom. The addition of the heavy atom (or ion) to the structure should not affect the crystal formation or unit cell dimensions in comparison to its native form, hence, they should be isomorphic. Data sets from the native and heavy-atom derivative of the sample are first collected. Then the interpretation of the Patterson difference map reveals the heavy atom's location in the unit cell. This allows both the amplitude and the phase of the heavy-atom contribution to be determined. Since the structure factor of the heavy atom derivative (Fph) of the crystal is the vector sum of the lone heavy atom (Fh) and the native crystal (Fp) then the phase of the native Fp and Fph vectors can be s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phase Problem
In physics, the phase problem is the problem of loss of information concerning the phase that can occur when making a physical measurement. The name comes from the field of X-ray crystallography, where the phase problem has to be solved for the determination of a structure from diffraction data. The phase problem is also met in the fields of imaging and signal processing. Various approaches of phase retrieval have been developed over the years. Overview Light detectors, such as photographic plates or CCDs, measure only the intensity of the light that hits them. This measurement is incomplete (even when neglecting other degrees of freedom such as polarization and angle of incidence) because a light wave has not only an amplitude (related to the intensity), but also a phase (related to the direction), and polarization which are systematically lost in a measurement. In diffraction or microscopy experiments, the phase part of the wave often contains valuable information on the stu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X-ray Crystallography
X-ray crystallography is the experimental science of determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to Diffraction, diffract in specific directions. By measuring the angles and intensities of the X-ray diffraction, a crystallography, crystallographer can produce a three-dimensional picture of the density of electrons within the crystal and the positions of the atoms, as well as their chemical bonds, crystallographic disorder, and other information. X-ray crystallography has been fundamental in the development of many scientific fields. In its first decades of use, this method determined the size of atoms, the lengths and types of chemical bonds, and the atomic-scale differences between various materials, especially minerals and alloys. The method has also revealed the structure and function of many biological molecules, including vitamins, drugs, proteins and nucleic acids such as DNA. X-ray crystall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Institution
The Royal Institution of Great Britain (often the Royal Institution, Ri or RI) is an organisation for scientific education and research, based in the City of Westminster. It was founded in 1799 by the leading British scientists of the age, including Henry Cavendish and its first president, George Finch. Its foundational principles were diffusing the knowledge of, and facilitating the general introduction of useful mechanical inventions and improvements, as well as enhancing the application of science to the common purposes of life (including through teaching, courses of philosophical lectures, and experiments). Much of the Institution's initial funding and the initial proposal for its founding were given by the Society for Bettering the Conditions and Improving the Comforts of the Poor, under the guidance of philanthropist Sir Thomas Bernard and American-born British scientist Sir Benjamin Thompson, Count Rumford. Since its founding it has been based at 21 Albemarle Stree ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linus Pauling
Linus Carl Pauling ( ; February 28, 1901August 19, 1994) was an American chemist and peace activist. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. ''New Scientist'' called him one of the 20 greatest scientists of all time. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of five people to have Nobel Prize#Multiple laureates, won more than one Nobel Prize. Of these, he is the only person to have been awarded two unshared Nobel Prizes, and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie. Pauling was one of the founders of the fields of quantum chemistry and molecular biology. His contributions to the theory of the chemical bond include the concept of orbital hybridisation and the first accurate scale of electronegativity, electronegativities of the elements. Pauling also wo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexander Rich
Alexander Rich (15 November 1924 – 27 April 2015) was an American biologist and biophysicist. He was the William Thompson Sedgwick Professor of Biophysics at MIT (since 1958) and Harvard Medical School. Rich earned an A.B. ('' magna cum laude'') and an M.D. ('' cum laude'') from Harvard University. He was a post-doc of Linus Pauling. During this time he was a member of the RNA Tie Club, a social and discussion group which attacked the question of how DNA encodes proteins. He has over 600 publications to his name. Born in Hartford, Connecticut, Rich was the founder of Alkermes and was a director beginning in 1987. Rich was co-chairman of the board of directors of Repligen, a biopharmaceutical company. He also served on the editorial board of ''Genomics'' and the ''Journal of Biomolecular Structure and Dynamics''. Personal life Rich spent his early life in Springfield, Massachusetts. He grew up in a working-class family and worked in the U.S. Armory while he was in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Edinburgh
The University of Edinburgh (, ; abbreviated as ''Edin.'' in Post-nominal letters, post-nominals) is a Public university, public research university based in Edinburgh, Scotland. Founded by the City of Edinburgh Council, town council under the authority of a royal charter from King James VI and I, James VI in 1582 and officially opened in 1583, it is one of Scotland's Ancient universities of Scotland, four ancient universities and the List of oldest universities in continuous operation, sixth-oldest university in continuous operation in the English-speaking world. The university played a crucial role in Edinburgh becoming a leading intellectual centre during the Scottish Enlightenment and contributed to the city being nicknamed the "Etymology of Edinburgh#Athens of the North, Athens of the North". The three main global university rankings (Academic Ranking of World Universities, ARWU, Times Higher Education World University Rankings, THE, and QS World University Rankings, QS) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1976 Deaths
Events January * January 2 – The International Covenant on Economic, Social and Cultural Rights enters into force. * January 5 – The Pol Pot regime proclaims a new constitution for Democratic Kampuchea. * January 18 – Full diplomatic relations are established between Bangladesh and Pakistan 5 years after the Bangladesh Liberation War. * January 27 ** The United States vetoes a United Nations resolution that calls for an independent Palestinian state. ** The First Battle of Amgala breaks out between Morocco and Algeria in the Spanish Sahara. February * February 4 ** The 1976 Winter Olympics begin in Innsbruck, Austria. ** The 7.5 Guatemala earthquake affects Guatemala and Honduras with a maximum Mercalli intensity of IX (''Violent''), leaving 23,000 dead and 76,000 injured. * February 9 – The Australian Defence Force is formed by unification of the Australian Army, the Royal Australian Navy and the Royal Australian Air Force. * February 13 – General ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
