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David Gottlieb (biologist)
David Gottlieb (1911–1982), a professor of plant pathology at the University of Illinois at Urbana-Champaign (1946–1982), was a pioneer in the field of fungal physiology and antibiotics for plants. Gottlieb is best known for isolation in the 1940s of the strain of Streptomyces from which chloramphenicol was developed, for his mentoring in the field, and for his editorial work. He used plant-pathogenic fungi in studies of sterol biosynthesis, respiration, aging, spore germination, and the mechanism of action of antifungal antibiotics. Gottlieb discovered or co-discovered several new antibiotics in addition to chloramphenicol, including filipin, levomycin, and tetrin, and he described the mechanism of action and biosynthesis of several of these and other antibiotics. Honors *Guggenheim Fellow, Biology-Plant Science, 1963. *Fellow, The American Phytopathological Society, 1966. *Editor for the ''Annual Review of Phytopathology'', 1969–1974. In his memory, the "David Gottl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Illinois At Urbana-Champaign
The University of Illinois Urbana-Champaign (UIUC, U of I, Illinois, or University of Illinois) is a public land-grant research university in the Champaign–Urbana metropolitan area, Illinois, United States. Established in 1867, it is the founding campus and flagship institution of the University of Illinois System. With over 59,000 students, the University of Illinois is one of the largest public universities by enrollment in the United States. The university contains 16 schools and colleges and offers more than 150 undergraduate and over 100 graduate programs of study. The university holds 651 buildings on and its annual operating budget in 2016 was over $2 billion. The University of Illinois Urbana-Champaign also operates a research park home to innovation centers for over 90 start-up companies and multinational corporations. The University of Illinois Urbana-Champaign is a member of the Association of American Universities and is classified among "R1: Doctoral Univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Filipin
Filipin is a mixture of chemical compounds first isolated by chemists at the Upjohn company in 1955 from the mycelium and culture filtrates of a previously unknown actinomycete, '' Streptomyces filipinensis''. It was discovered in a soil sample collected in the Philippine Islands, hence the name filipin. The isolate possessed potent antifungal activity. It was identified as a polyene macrolide based on its characteristic UV-Vis and IR spectra. Functions Although the polyene macrolide antibiotics exhibit potent antifungal activity, most are too toxic for therapeutic applications, with the exceptions of amphotericin B and nystatin A1. Unlike amphotericin B and nystatin A1 which form sterol-dependent ion channels, filipin is thought to be a simple membrane disrupter. Since filipin is highly fluorescent and binds specifically to cholesterol, it has found widespread use as a histochemical stain for cholesterol. This method of detecting cholesterol in cell membranes is used cli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1911 Births
Events January * January 1 – A decade after federation, the Northern Territory and the Australian Capital Territory are added to the Commonwealth of Australia. * January 3 ** 1911 Kebin earthquake: An earthquake of 7.7 Moment magnitude scale, moment magnitude strikes near Almaty in Russian Turkestan, killing 450 or more people. ** Siege of Sidney Street in London: Two Latvian people, Latvian anarchists die, after a seven-hour siege against a combined police and military force. Home Secretary Winston Churchill arrives to oversee events. * January 4 – Comparison of the Amundsen and Scott expeditions, Amundsen and Scott expeditions: Robert Falcon Scott's British Terra Nova Expedition, ''Terra Nova'' Expedition to the South Pole arrives in the Antarctic and establishes a base camp at Cape Evans on Ross Island. * January 5 – Egypt's Zamalek SC is founded as a general sports and Association football club by Belgian lawyer George Merzbach as Q ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Illinois Urbana-Champaign Faculty
A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law and notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens, Hilde''A History of the University in Europe: Volume 1, Universities in the Midd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Phytopathologists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports teams S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mechanism Of Action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical Drug interaction, interaction through which a Medication, drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor (biochemistry), receptor. Receptor sites have specific affinities for drugs based on the chemical structure of the drug, as well as the specific action that occurs there. Drugs that do not bind to receptors produce their corresponding therapeutic effect by simply interacting with chemical or physical properties in the body. Common examples of drugs that work in this way are antacids and laxatives. In contrast, a Mode of action, mode of action (MoA) describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living organism to a substance. Importance Elucidating the mechanism of action of novel drugs and medicati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fu-Kuen Lin
Fu-Kuen Lin (; born 1941 in Keelung, Taiwan) is a Taiwanese mycological physiologist, nephrologist and hematologist. Education and career Lin received his B.S. from National Taiwan University in 1964 and then a M.S. in plant pathology in 1967. That year, he moved to the United States to study fungi physiology under Professor David Gottlieb at the University of Illinois at Urbana-Champaign. Lin was awarded a doctorate in plant pathology in 1971. He held postdoctoral and visiting scientist positions at several institutions between 1971 and 1981. He was an associate research fellow at the Institute of Botany of Academia Sinica in Taiwan from 1975 to 1977 and was an adjunct associate professor at National Taiwan University from 1976 to 1977. Fu-Kuen Lin joined Amgen, a biotech company as a research scientist in August 1981. He was involved with Amgen's recombinant human erythropoietin (EPO) project from the start, and was soon leading the team, which was developing EPO based on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spore Germination
Germination is the process by which an organism grows from a seed or spore. The term is applied to the sprouting of a seedling from a seed of an angiosperm or gymnosperm, the growth of a sporeling from a spore, such as the spores of fungi, ferns, bacteria, and the growth of the pollen tube from the pollen grain of a seed plant. Seed plants Germination is usually the growth of a plant contained within a seed resulting in the formation of the seedling. It is also the process of reactivation of metabolic machinery of the seed resulting in the emergence of radicle and plumule. The seed of a vascular plant is a small package produced in a fruit or cone after the union of male and female reproductive cells. All fully developed seeds contain an embryo and, in most plant species some store of food reserves, wrapped in a seed coat. Dormant seeds are viable seeds that do not germinate because they require specific internal or environmental stimuli to resume growth. Under proper ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
