Cyril Clarke
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Cyril Clarke
Sir Cyril Astley Clarke, KBE, FRCP, FRCOG, (Hon) FRC Path, FRS (22 August 1907 – 21 November 2000) was a British physician, geneticist and lepidopterist. He was honoured for his pioneering work on prevention of Rh disease of the newborn, and also for his work on the genetics of the Lepidoptera ( butterflies and moths). Biography Cyril Clarke was born on 22 August 1907 in Leicester, England and received his school education at Wyggeston Grammar School for Boys, Leicester and at the independent Oundle School near Peterborough. His interest in butterflies and moths began at school. His studied natural science at Gonville and Caius College, Cambridge, graduating in 1929, and then medicine at Guy's Hospital, London, graduating in 1932. During the Second World War he worked as a medical specialist in the Royal Naval Volunteer Reserve. After the war Clarke worked as a registrar at the Queen Elizabeth Hospital in Birmingham and then as Consultant Physician at the United Liverpoo ...
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Leicester
Leicester ( ) is a city status in the United Kingdom, city, Unitary authorities of England, unitary authority and the county town of Leicestershire in the East Midlands of England. It is the largest settlement in the East Midlands. The city lies on the River Soar and close to the eastern end of the National Forest, England, National Forest. It is situated to the north-east of Birmingham and Coventry, south of Nottingham and west of Peterborough. The population size has increased by 38,800 ( 11.8%) from around 329,800 in 2011 to 368,600 in 2021 making it the most populous municipality in the East Midlands region. The associated Urban area#United Kingdom, urban area is also the 11th most populous in England and the List of urban areas in the United Kingdom, 13th most populous in the United Kingdom. Leicester is at the intersection of two railway lines: the Midland Main Line and the Birmingham to London Stansted Airport line. It is also at the confluence of the M1 motorway, M1/M ...
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Lepidopterist
Lepidopterology ()) is a branch of entomology concerning the scientific study of moths and the three superfamilies of butterflies. Someone who studies in this field is a lepidopterist or, archaically, an aurelian. Origins Post-Renaissance, the rise of the "lepidopterist" can be attributed to the expanding interest in science, nature and the surroundings. When Linnaeus wrote the tenth edition of the '' Systema Naturae'' in 1758, there was already "a substantial body of published work on Lepidopteran natural history" (Kristensen, 1999). These included: * ''Insectorum sive Minimorum Animalium Theatrum'' – Thomas Mouffet (1634) * ''Metamorphosis Naturalis'' – Jan Goedart (1662–67 ) * ''Metamorphosis insectorum Surinamensium'' – Maria S. Merian (1705), whose work included illustrated accounts of European Lepidoptera * ''Historia Insectorum'' – John Ray (1710) * ''Papilionum Brittaniae icones'' – James Petiver (1717) History Scholars 1758–1900 was the era of th ...
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Philip Sheppard (biologist)
Professor Philip MacDonald Sheppard, F.R.S. (27 July 1921 – 17 October 1976) was a British geneticist and lepidopterist. He made advances in ecological and population genetics in lepidopterans, pulmonate land snails and humans. In medical genetics, he worked with Sir Cyril Clarke on Rh disease. He was born on 27 July 1921 in Marlborough, Wiltshire, England and attended Marlborough College from 1935 to 1939. *1940 to 1945 - Royal Air Force Volunteer Reserve (prisoner-of-war from 1942 to 1945). Participated, as an earth-bearer, in one of the famous tunnel escapes; it is unclear whether this was the "Wooden Horse" escape, or the "Great" EscapeDictionary of Scientific Biography vol 17, supplement 2 pp 814–816 *1946 to 1948 - Studied Zoology at Worcester College, University of Oxford. *1956 to 1959 - Lecturer at Liverpool University *1959 to 1962 - Reader at Liverpool University *1963 to 1976 - Professor of genetics at Liverpool University *18 March 1965 - FRS *1974 - Da ...
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Pupae
A pupa ( la, pupa, "doll"; plural: ''pupae'') is the life stage of some insects undergoing transformation between immature and mature stages. Insects that go through a pupal stage are holometabolous: they go through four distinct stages in their life cycle, the stages thereof being egg, larva, pupa, and imago. The processes of entering and completing the pupal stage are controlled by the insect's hormones, especially juvenile hormone, prothoracicotropic hormone, and ecdysone. The act of becoming a pupa is called pupation, and the act of emerging from the pupal case is called eclosion or emergence. The pupae of different groups of insects have different names such as ''chrysalis'' for the pupae of butterflies and ''tumbler'' for those of the mosquito family. Pupae may further be enclosed in other structures such as cocoons, nests, or shells. Position in life cycle The pupal stage follows the larval stage and precedes adulthood (''imago'') in insects with complete metamorphosi ...
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Swallowtail Butterfly
Swallowtail butterflies are large, colorful butterflies in the family Papilionidae, and include over 550 species. Though the majority are tropical, members of the family inhabit every continent except Antarctica. The family includes the largest butterflies in the world, the birdwing butterflies of the genus ''Ornithoptera''. Swallowtails have a number of distinctive features; for example, the papilionid caterpillar bears a repugnatorial organ called the osmeterium on its prothorax. The osmeterium normally remains hidden, but when threatened, the larva turns it outward through a transverse dorsal groove by inflating it with fluid. The forked appearance in some of the swallowtails' hindwings, which can be seen when the butterfly is resting with its wings spread, gave rise to the common name ''swallowtail''. As for its formal name, Linnaeus chose ''Papilio'' for the type genus, as ''papilio'' is Latin for "butterfly". For the specific epithets of the genus, Linnaeus applied th ...
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Preventive Medicine
Preventive healthcare, or prophylaxis, consists of measures taken for the purposes of disease prevention.Hugh R. Leavell and E. Gurney Clark as "the science and art of preventing disease, prolonging life, and promoting physical and mental health and efficiency. Leavell, H. R., & Clark, E. G. (1979). Preventive Medicine for the Doctor in his Community (3rd ed.). Huntington, NY: Robert E. Krieger Publishing Company. Disease and disability are affected by environmental factors, genetic predisposition, disease agents, and lifestyle choices, and are dynamic processes which begin before individuals realize they are affected. Disease prevention relies on anticipatory actions that can be categorized as primal, primary, secondary, and tertiary prevention. Each year, millions of people die of preventable deaths. A 2004 study showed that about half of all deaths in the United States in 2000 were due to preventable behaviors and exposures. Leading causes included cardiovascular disease, ...
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Antibodies
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few va ...
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Royal Naval Reserve
The Royal Naval Reserve (RNR) is one of the two volunteer reserve forces of the Royal Navy in the United Kingdom. Together with the Royal Marines Reserve, they form the Maritime Reserve. The present RNR was formed by merging the original Royal Naval Reserve, created in 1859, and the Royal Naval Volunteer Reserve (RNVR), created in 1903. The Royal Naval Reserve has seen action in World War I, World War II, the Iraq War, and War in Afghanistan. History Establishment The Royal Naval Reserve (RNR) has its origins in the Register of Seamen, established in 1835 to identify men for naval service in the event of war, although just 400 volunteered for duty in the Crimean War in 1854 out of 250,000 on the Register. This led to a Royal Commission on Manning the Navy in 1858, which in turn led to the Naval Reserve Act of 1859. This established the RNR as a reserve of professional seamen from the British Merchant Navy and fishing fleets, who could be called upon during times of war ...
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Second World War
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies and the Axis powers. World War II was a total war that directly involved more than 100 million personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the only two nuclear weapons ever used in war. World War II was by far the deadliest conflict in human history; it resulted in 70 to 85 million fatalities, mostly among civilians. Tens of millions died due to genocides (including the Holocaust), starvat ...
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Gonville And Caius College, Cambridge
Gonville and Caius College, often referred to simply as Caius ( ), is a constituent college of the University of Cambridge in Cambridge, England. Founded in 1348, it is the fourth-oldest of the University of Cambridge's 31 colleges and one of the wealthiest. The college has been attended by many students who have gone on to significant accomplishment, including fifteen Nobel Prize winners, the second-highest of any Oxbridge college after Trinity College, Cambridge. The college has long historical associations with the teaching of medicine, especially due to its prominent alumni in the medical profession. It also has globally-recognized and prestigious academic programmes in law, economics, English literature, and history. Famous Gonville and Caius alumni include physicians John Caius (who gave the college the caduceus in its insignia) and William Harvey. Other alumni in the sciences include Francis Crick (joint discoverer of the structure of DNA with James Watson), Jam ...
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Peterborough
Peterborough () is a cathedral city in Cambridgeshire, east of England. It is the largest part of the City of Peterborough unitary authority district (which covers a larger area than Peterborough itself). It was part of Northamptonshire until 1974, when county boundary change meant the city became part of Cambridgeshire instead. The city is north of London, on the River Nene which flows into the North Sea to the north-east. In 2020 the built-up area subdivision had an estimated population of 179,349. In 2021 the Unitary Authority area had a population of 215,671. The local topography is flat, and in some places, the land lies below sea level, for example in parts of the Fens to the east and to the south of Peterborough. Human settlement in the area began before the Bronze Age, as can be seen at the Flag Fen archaeological site to the east of the current city centre, also with evidence of Roman occupation. The Anglo-Saxon period saw the establishment of a monastery, Mede ...
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Oundle School
Oundle School is a public school (English independent day and boarding school) for pupils 11–18 situated in the market town of Oundle in Northamptonshire, England. The school has been governed by the Worshipful Company of Grocers of the City of London since its foundation by Sir William Laxton in 1556. The school's alumni – known as Old Oundelians – include renowned entrepreneurs, scientists, politicians, military figures and sportspeople. Oundle has eight boys' houses, five girls' houses, a day house, a junior house and a junior day house. Together these accommodate more than 1100 pupils, generally between the ages of 11 and 18. It is the third-largest boarding school in England after Eton and Millfield. The current Headmistress is Sarah Kerr-Dineen, who in 2015 became the first woman to lead the school. The school is a member of the Headmasters' and Headmistresses' Conference. History The school was founded by Sir William Laxton and originally known as Laxton Gram ...
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