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CYP3A5
Cytochrome P450 3A5 is a protein that in humans is encoded by the ''CYP3A5'' gene. Tissue distribution ''CYP3A5'' encodes a member of the cytochrome P450 superfamily of enzymes. Like most of the cytochrome P450, the CYP3A5 is expressed in the prostate and the liver. It is also expressed in epithelium of the small intestine and large intestine for uptake and in small amounts in the bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level). Clinical significance The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nife ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytochrome P450
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that functions as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In 1963, Estabrook, Cooper, and Rosenthal described the role of CYP as a catalyst in steroid hormone synthesis and drug metabolism. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones. CYP enzymes have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, and archaea, as well as in viruses. However, they are not omnipresent; for example, they have not been found in ''Escherichia coli''. , more than 300,000 distinct CYP proteins are known. CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is deriv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Afar People
The Afar ( aa, Qafár), also known as the Danakil, Adali and Odali, are a Cushitic-speaking ethnic group inhabiting the Horn of Africa. They primarily live in the Afar Region of Ethiopia and in northern Djibouti, as well as the entire southern coast of Eritrea. The Afar speak the Afar language, which is part of the Cushitic branch of the Afroasiatic family. Afars are the only inhabitants of the Horn of Africa whose traditional territories border both the Red Sea and the Gulf of Aden. History Early history The earliest surviving written mention of the Afar is from the 13th-century Andalusian writer Ibn Sa'id, who reported that they inhabited the area around the port of Suakin, as far south as Mandeb, near Zeila. They are mentioned intermittently in Ethiopian records, first as helping Emperor Amda Seyon in a campaign beyond the Awash River, then over a century later when they assisted Emperor Baeda Maryam when he campaigned against their neighbors the Dobe'a. According ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aka People
Aka, AKA or a.k.a. may refer to: * "Also known as", used to introduce an alternative name Languages * Aka language (Sudan) * Aka language, in the Central African Republic * Hruso language, in India, also referred to as Aka * a prefix in the names of Great Andamanese languages * Akan language (ISO 639-2 and ISO 639-3 codes) People * Aka (name), a list of people with the given name or surname * Aka people, in the Central African Republic and Congo * Aka (tribe), of Kameng, Arunachal Pradesh, India * AKA (rapper), stage name of South African Kiernan Forbes (born 1988) Places Japan * Aka, Fukuoka, a village * Mount Aka (Daisetsuzan), Daisetsuzan National Park, Hokkaidō * Mount Aka (Yatsugatake), Yatsugatake Mountains, Honshū * Aka Island, Okinawa Prefecture * Aka River, Yamagata Prefecture Elsewhere * Aka, Hungary, a village * Aka Hills, Arunachal Pradesh, India * Aka, Iran, a village in Khuzestan Province Arts and entertainment Film and television * ''AKA'' (film), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berbers
, image = File:Berber_flag.svg , caption = The Berber ethnic flag , population = 36 million , region1 = Morocco , pop1 = 14 million to 18 million , region2 = Algeria , pop2 = 9 million to ~13 million , region3 = Mauritania , pop3 = 2.9 million , region4 = Niger , pop4 = 2.6 million, Niger: 11% of 23.6 million , region5 = France , pop5 = 2 million , region6 = Mali , pop6 = 850,000 , region7 = Libya , pop7 = 600,000 , region8 = Belgium , pop8 = 500,000 (including descendants) , region9 = Netherlands , pop9 = 467,455 (including descendants) , region10 = Burkina Faso , pop10 = 406,271, Burkina Faso: 1.9% of 21.4 million , region11 = Egypt , pop11 = 23,000 or 1,826,580 , region12 = Tunisia , pop12 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bedouin
The Bedouin, Beduin, or Bedu (; , singular ) are nomadic Arabs, Arab tribes who have historically inhabited the desert regions in the Arabian Peninsula, North Africa, the Levant, and Mesopotamia. The Bedouin originated in the Syrian Desert and Arabian Desert but spread across the rest of the Arab world in Western Asia, West Asia and North Africa after the spread of Islam. The English word ''bedouin'' comes from the Arabic ''badawī'', which means "desert dweller", and is traditionally contrasted with ''ḥāḍir'', the term for Sedentism, sedentary people. Bedouin territory stretches from the vast deserts of North Africa to the rocky sands of the Middle East. They are traditionally divided into tribes, or clans (known in Arabic as ''ʿašāʾir''; or ''qabāʾil'' ), and historically share a common culture of herding camels and goats. The vast majority of Bedouins adhere to Islam, although there are some fewer numbers of Arab Christians, Christian Bedouins present in the Fe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basques
The Basques ( or ; eu, euskaldunak ; es, vascos ; french: basques ) are a Southwestern European ethnic group, characterised by the Basque language, a common culture and shared genetic ancestry to the ancient Vascones and Aquitanians. Basques are indigenous to, and primarily inhabit, an area traditionally known as the Basque Country ( eu, Euskal Herria) — a region that is located around the western end of the Pyrenees on the coast of the Bay of Biscay and straddles parts of north-central Spain and south-western France. Etymology The English word ''Basque'' may be pronounced or and derives from the French ''Basque'' (), itself derived from Gascon ''Basco'' (pronounced ), cognate with Spanish ''Vasco ''(pronounced ). Those, in turn, come from Latin ''Vascō'' (pronounced ; plural '' Vascōnes''—see history section below). The Latin generally evolved into the bilabials and in Gascon and Spanish, probably under the influence of Basque and the related Aquita ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bantu Peoples
The Bantu peoples, or Bantu, are an ethnolinguistic grouping of approximately 400 distinct ethnic groups who speak Bantu languages. They are native to 24 countries spread over a vast area from Central Africa to Southeast Africa and into Southern Africa. There are several hundred Bantu languages. Depending on the definition of "language" or "dialect", it is estimated that there are between 440 and 680 distinct languages. The total number of speakers is in the hundreds of millions, ranging at roughly 350 million in the mid-2010s (roughly 30% of the population of Africa, or roughly 5% of the total world population). About 60 million speakers (2015), divided into some 200 ethnic or tribal groups, are found in the Democratic Republic of the Congo alone. The larger of the individual Bantu groups have populations of several million, e.g. the people of Rwanda and Burundi (25 million), the Bagandapeople of Uganda (10 million as of 2019), the Shona of Zimbabwe (15 million ), the Zulu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Baloch People
The Baloch or Baluch ( bal, بلۏچ, Balòc) are an Iranian people who live mainly in the Balochistan region, located at the southeasternmost edge of the Iranian plateau, encompassing the countries of Pakistan, Iran, and Afghanistan. There are also Baloch diaspora communities in neighbouring regions, including in India, Turkmenistan, and the Arabian Peninsula. The Baloch people mainly speak Balochi, a Northwestern Iranian language, despite their contrasting location on the southeastern side of the Persosphere. The majority of Baloch reside within Pakistan. About 50% of the total ethnic Baloch population live in the Pakistani province of Balochistan, while 40% are settled in Sindh and a significant albeit smaller number reside in Pakistani Punjab. They make up nearly 3.6% of Pakistan's total population, and around 2% of the populations of both Iran and Afghanistan. Etymology The exact origin of the word 'Baloch' is unclear. * Rawlinson (1873) believed that it is de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ashkenazi Jews
Ashkenazi Jews ( ; he, יְהוּדֵי אַשְׁכְּנַז, translit=Yehudei Ashkenaz, ; yi, אַשכּנזישע ייִדן, Ashkenazishe Yidn), also known as Ashkenazic Jews or ''Ashkenazim'',, Ashkenazi Hebrew pronunciation: , singular: , Modern Hebrew: are a Jewish diaspora population who coalesced in the Holy Roman Empire around the end of the first millennium CE. Their traditional diaspora language is Yiddish (a West Germanic language with Jewish linguistic elements, including the Hebrew alphabet), which developed during the Middle Ages after they had moved from Germany and France into Northern Europe and Eastern Europe. For centuries, Ashkenazim in Europe used Hebrew only as a sacred language until the revival of Hebrew as a common language in 20th-century Israel. Throughout their numerous centuries living in Europe, Ashkenazim have made many important contributions to its philosophy, scholarship, literature, art, music, and science. The rabbinical t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ashanti People
The Asante, also known as Ashanti () are part of the Akan ethnic group and are native to the Ashanti Region of modern-day Ghana. Asantes are the last group to emerge out of the various Akan civilisations. Twi is spoken by over nine million Asante people as a first or second language. The wealthy, gold-rich Asante people developed the large and influential Ashanti Empire, along the Lake Volta and Gulf of Guinea. The empire was founded in 1670, and the capital Kumase was founded in 1680 by Asantehene (emperor) Osei Kofi Tutu I on the advice of Okomfo Anokye, his premier. Sited at the crossroads of the Trans-Saharan trade, the Kumase megacity's strategic location contributed significantly to its growing wealth. Over the duration of the Kumase metropolis' existence, a number of peculiar factors have combined to transform the Kumase metropolis into a financial centre and political capital. The main causal factors included the unquestioning loyalty to the Asante rulers and t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Armenian People
Armenians ( hy, հայեր, '' hayer'' ) are an ethnic group native to the Armenian highlands of Western Asia. Armenians constitute the main population of Armenia and the ''de facto'' independent Artsakh. There is a wide-ranging diaspora of around five million people of full or partial Armenian ancestry living outside modern Armenia. The largest Armenian populations today exist in Russia, the United States, France, Georgia, Iran, Germany, Ukraine, Lebanon, Brazil, and Syria. With the exceptions of Iran and the former Soviet states, the present-day Armenian diaspora was formed mainly as a result of the Armenian genocide. Richard G. Hovannisian, ''The Armenian people from ancient to modern times: the fifteenth century to the twentieth century'', Volume 2, p. 421, Palgrave Macmillan, 1997. Armenian is an Indo-European language. It has two mutually intelligible spoken and written forms: Eastern Armenian, today spoken mainly in Armenia, Artsakh, Iran, and the former Soviet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
