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Craniodiaphyseal Dysplasia
Craniodiaphyseal dysplasia (CDD), also known as lionitis, is an extremely rare autosomal recessive bone disorder that causes calcium to build up in the skull, disfiguring the facial features and reducing life expectancy. These calcium deposits decrease the size of cranial foramina, and can decrease the circumference of the cervical spinal canal. In the few cases recorded, most died in childhood. Symptoms and signs Cause The underlying genetics are uncertain. Diagnosis Among the medical signs are dacryocystitis, seizures, intellectual disability, and paralysis, each of which is a complication resulting from the diminutive foramina. A common sign reported as a result of the disease has been widely spaced eyes. Society and culture Peter Bogdanovich's 1985 drama film ''Mask'' drew public attention to the case of Roy Lee "Rocky" Dennis, an American boy with this disorder who died at the age of 16, in 1978. In the American medical drama ''Grey's Anatomy'' episode " Yesterday", Je ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autosomal Recessive
In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the Phenotype, effect of a different variant of the same gene on Homologous chromosome, the other copy of the chromosome. The first variant is termed dominant and the second is called recessive. This state of having Heterozygosity, two different variants of the same gene on each chromosome is originally caused by a mutation in one of the genes, either new (''de novo'') or Heredity, inherited. The terms autosomal dominant or autosomal recessive are used to describe gene variants on non-sex chromosomes (autosomes) and their associated traits, while those on sex chromosomes (allosomes) are termed X-linked dominant, X-linked recessive or Y-linked; these have an inheritance and presentation pattern that depends on the sex of both the parent and the child (see Sex linkage). Since there is only one Y chromosome, Y-linked traits cannot be dominant or recessive. Additionally, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roy L
Roy or Roi is a masculine given name and a family surname with varied origins. France In France, this family name originated from the Normans, the descendants of Norse Vikings who migrated to Amigny, a commune in Manche, Normandy.. The derivation is from the Old French ''roy'', ''roi'' (), meaning "king", which was a Epithet">byname used before the Norman Conquest and a personal name in the Middle Ages. Earliest references cite ''Guillaume de Roy'' (William of Roy), who was a knight of the Knights Templar and one of several knights and feudal lords (seigneur) of the Roy family in France and Switzerland. In Canada and in the United States, the descendants of the families of Roy, Le Roy that immigrated to North America have been granted a coat of arms by the Governor General of Canada. England After the Norman Conquest, the victorious Normans and their allies settled England and eventually formed the ruling class of nobles called Anglo-Normans. Roy, or Roi was a family na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autosomal Recessive Disorders
An autosome is any chromosome that is not a sex chromosome. The members of an autosome pair in a diploid cell have the same morphology, unlike those in allosomal (sex chromosome) pairs, which may have different structures. The DNA in autosomes is collectively known as atDNA or auDNA. For example, humans have a diploid genome that usually contains 22 pairs of autosomes and one allosome pair (46 chromosomes total). The autosome pairs are labeled with numbers (1–22 in humans) roughly in order of their sizes in base pairs, while allosomes are labelled with their letters. By contrast, the allosome pair consists of two X chromosomes in females or one X and one Y chromosome in males. Unusual combinations XYY, XXY, XXX, XXXX, XXXXX or XXYY, among other irregular combinations, are known to occur and usually cause developmental abnormalities. Autosomes still contain sexual determination genes even though they are not sex chromosomes. For example, the SRY gene on the Y chromosome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Congenital Disorders Of Musculoskeletal System
A birth defect is an abnormal condition that is present at birth, regardless of its cause. Birth defects may result in disabilities that may be physical, intellectual, or developmental. The disabilities can range from mild to severe. Birth defects are divided into two main types: structural disorders in which problems are seen with the shape of a body part and functional disorders in which problems exist with how a body part works. Functional disorders include metabolic and degenerative disorders. Some birth defects include both structural and functional disorders. Birth defects may result from genetic or chromosomal disorders, exposure to certain medications or chemicals, or certain infections during pregnancy. Risk factors include folate deficiency, drinking alcohol or smoking during pregnancy, poorly controlled diabetes, and a mother over the age of 35 years old. Many birth defects are believed to involve multiple factors. Birth defects may be visible at birth or diagn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leontiasis Ossea
Leontiasis ossea, also known as leontiasis, lion face or lion face syndrome, is a rare medical condition, characterized by an overgrowth of the facial and cranial bones. It is not a disease in itself, but a symptom of other diseases, including Paget's disease, fibrous dysplasia, hyperparathyroidism and renal osteodystrophy. The common form is that in which one or other maxilla is affected, its size progressively increasing, and thus encroaching on the cavities of the orbit, the mouth, the nose and its accessory sinuses. Exophthalmos gradually develops, going on later to a complete loss of sight due to compression of the optic nerve by the overgrowth of bone. There may also be interference with the nasal respiration and with the taking of food. In the somewhat less common form of this rare disease the overgrowth of bone affects all the cranial bones as well as those of the face, the senses being lost one by one and death finally resulting from cerebral pressure. There is no treatme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Horror Story
''American Horror Story'' (''AHS'') is an American horror film, horror anthology series, anthology television series created by Ryan Murphy (producer), Ryan Murphy and Brad Falchuk for the Cable television, cable network FX (TV channel), FX. The first installment in the ''American Story'' media franchise, seasons of ''AHS'' are mostly conceived as self-contained miniseries, following a different set of characters in a new setting within the same fictional universe (which the show occasionally utilizes for crossover (fiction), crossovers between seasons, and shares with episodic spin-off ''American Horror Stories''), and a storyline with its own "beginning, middle, and end." Some plot elements of each season are loosely inspired by true events. Many actors appear in more than one season, usually playing a new character though sometimes as a returning character. Evan Peters, Sarah Paulson, and Lily Rabe have returned most frequently, with each having appeared in nine seasons, foll ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wildstorm Productions
Wildstorm Productions (stylized as WildStorm) is an American comic book imprint. Originally founded as an independent company established by Jim Lee and Brandon Choi to publish through Image Comics, Wildstorm became a publishing imprint of DC Comics in 1998. Until it was shut down in 2010, the Wildstorm imprint remained editorially separate from DC Comics, with its main studio located in California. The imprint took its name from a portmanteau of the titles of the Jim Lee comic series '' WildC.A.T.S.'' and '' Stormwatch''. Its main fictional universe, the Wildstorm Universe, featured costumed heroes. Wildstorm maintained a number of its core titles from its early period, and continued to publish material expanding its core universe. Its main titles included ''WildC.A.T.S'', ''Stormwatch'', '' Gen13'', '' Wetworks'', and '' The Authority.'' Wildstorm also published creator-owned material, and licensed properties from other companies, covering a wide variety of genres. Its cre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
How I Spent My Summer Vacation
How I Spent My Summer Vacation may refer to: * ''How I Spent My Summer Vacation'' (album), a 2001 album by the Bouncing Souls * ''How I Spent My Summer Vacation'' (1967 film), an American television film * ''How I Spent My Summer Vacation'' (1997 film), an American romantic comedy film * ''How I Spent My Summer Vacation'' (2012 film) or ''Get the Gringo'', an American crime thriller film See also * " How I Spent My Strummer Vacation", a 2002 episode of ''The Simpsons'' * '' Tiny Toon Adventures: How I Spent My Vacation'', a 1992 American animated film {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jesse Plemons
Jesse Plemons (; born April 2, 1988) is an American actor. He began his career as a child actor and achieved a breakthrough with his role as Landry Clarke in the NBC drama series '' Friday Night Lights'' (2006–2011). He subsequently portrayed Todd Alquist in the fifth and final season of the AMC crime drama series ''Breaking Bad'' (2012–2013) and its sequel film '' El Camino: A Breaking Bad Movie'' (2019). For his role as Ed Blumquist in season 2 of the FX anthology series '' Fargo'' (2015), he received his first Primetime Emmy Award nomination and won a Critics' Choice Television Award. He received a second Emmy nomination for his performance in " USS Callister", an episode of the Netflix anthology series '' Black Mirror'' (2017), and reprised the role in its 2025 sequel episode. Plemons has acted in supporting roles in film such as '' The Master'' (2012), '' Bridge of Spies'' (2015), '' Game Night'' (2018), '' The Irishman'' (2019), '' Judas and the Black Messia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grey's Anatomy (Season 2)
The second season of the American television medical drama ''Grey's Anatomy'' commenced airing on the American Broadcasting Company (ABC) on September 25, 2005, and concluded on May 15, 2006. The season was produced by Touchstone Television in conjunction with Shondaland production company and The Mark Gordon Company, the showrunner being Shonda Rhimes. Actors Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, and T. R. Knight reprised their roles as surgical interns Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, and George O'Malley respectively. Previous main cast members Chandra Wilson, James Pickens, Jr., Isaiah Washington and Patrick Dempsey also returned, while Kate Walsh, who began the season in a recurring capacity, was promoted to series-regular status, after appearing in 7 episodes as a guest-star. Internationally, the season was distributed by Buena Vista International Television. The season continued to focus on the surgical residency of five yo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grey's Anatomy
''Grey's Anatomy'' is an American medical drama television series focusing on the personal and professional lives of surgical internship (medicine), interns, residency (medicine), residents, and attending physician, attendings at the fictional Seattle Grace Hospital, later named the Grey Sloan Memorial Hospital. The series premiered on March 27, 2005, on American Broadcasting Company, ABC as a mid-season replacement. The show's title is a reference to ''Gray's Anatomy'', a classic human anatomy textbook. Writer Shonda Rhimes developed the pilot and served as showrunner, head writer, and executive producer until stepping down in 2015. Set in Seattle, Washington, the series is filmed primarily in Los Angeles, California, and Vancouver, British Columbia. The original cast consisted of nine star-billed actors: Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, T. R. Knight, Chandra Wilson, James Pickens Jr., Isaiah Washington, and Patrick Dempsey. For most of its run, the s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Drama
A medical drama is a Television film, television movie or film in which events center upon a hospital, clinic, doctor's office, a paramedic, or any other medical topic or environment. Most recent medical drama (film and television), dramatic programming goes beyond the events pertaining to the characters' jobs and portray some aspects of their personal lives. The longest running prime-time medical drama in the world is the British series ''Casualty (TV series), Casualty'', airing since 1986, and the longest running medical soap opera is ''General Hospital'', running since 1963. History ''City Hospital (U.S. TV series), City Hospital'', which first aired in 1951, is usually considered to be the first televised medical drama. (The first serialized medical drama was probably the ''Dr. Kildare'' film series (1937–1947), starring a number of actors in the eponymous role, and Lionel Barrymore throughout the series.) ''Medic (TV series), Medic'', which featured Richard Boone, ran two se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
