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Class II (other)
Class II may refer to: *Class II antiarrhythmic *Class II appliance *Class II bacteriocin *Class II cabinet * Class II electrical appliance *Class II gaming *Class II gene *Class II PI 3-kinases *Class II railroad *Class II star *MHC class II See also * Class 2 (other) Class 2 may refer to: * BR Standard Class 2 2-6-0, British steam locomotive * BR Standard Class 2 2-6-2T, British steam locomotive * Class 2 Touring Cars, FIA classification for cars in auto racing * Classes of U.S. Senators * L&YR Class 2, Briti ...
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Class II Antiarrhythmic
Antiarrhythmic agents, also known as cardiac dysrhythmia medications, are a group of pharmaceuticals that are used to suppress abnormally fast rhythms (Tachycardia, tachycardias), such as atrial fibrillation, supraventricular tachycardia and ventricular tachycardia. Many attempts have been made to classify antiarrhythmic agents. Many of the antiarrhythmic agents have multiple modes of action, which makes any classification imprecise. Vaughan Williams classification The Vaughan Williams classification was introduced in 1970 by Miles Vaughan Williams.Vaughan Williams, EM (1970) "Classification of antiarrhythmic drugs". In ''Symposium on Cardiac Arrhythmias'' (Eds. Sandoe E; Flensted-Jensen E; Olsen KH). Astra, Elsinore. Denmark (1970) Vaughan Williams was a pharmacology tutor at Hertford College, Oxford. One of his students, Bramah N. Singh, contributed to the development of the classification system. The system is therefore sometimes known as the Singh-Vaughan Williams classifica ...
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Class II Appliance
Appliance classes (also known as protection classes) specify measures to prevent dangerous contact voltages on unenergized parts, such as the metallic casing, of an electronic device. In the electrical appliance manufacturing industry, the following appliance classes are defined in IEC 61140 and used to differentiate between the protective-earth connection requirements of devices. Class 0 These appliances have no protective-earth connection and feature only a single level of insulation between live parts and exposed metalwork. If permitted at all, Class 0 items are intended for use in dry areas only. A single fault could cause an electric shock or other dangerous occurrence, without triggering the automatic operation of any fuse or circuit breaker. Sales of such items have been prohibited in much of the world for safety reasons, for example in the UK by Section 8 of The Low Voltage Electrical Equipment (Safety) Regulations 1989and New Zealand by thElectricity Act A typical examp ...
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Class II Bacteriocin
Class II bacteriocins are a class of small peptides that inhibit the growth of various bacteria. Many Gram-positive bacteria produce ribosomally synthesized antimicrobial peptides, termed bacteriocins. Bacteriocins for which disulfide bonds are the only modification to the peptide are Class II bacteriocins. Class IIa One important and well studied class of bacteriocins is the class IIa or pediocin-like bacteriocins produced by lactic acid bacteria. All class IIa bacteriocins are produced by food-associated strains, isolated from a variety of food products of industrial and natural origins, including meat products, dairy products and vegetables. Class IIa bacteriocins are all cationic, display anti-'' Listeria'' activity, and kill target cells by permeabilizing the cell membrane. Class IIa bacteriocins contain between 37 and 48 residues. Based on their primary structures, the peptide chains of class IIa bacteriocins may be divided roughly into two regions: a hydrophilic, ...
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Class II Cabinet
A biosafety cabinet (BSC)—also called a biological safety cabinet or microbiological safety cabinet—is an enclosed, ventilated laboratory workspace for safely working with materials contaminated with (or potentially contaminated with) pathogens requiring a defined biosafety level. Several different types of BSC exist, differentiated by the degree of biocontainment they provide. BSCs first became commercially available in 1950. Purposes The primary purpose of a BSC is to serve as a means to protect the laboratory worker and the surrounding environment from pathogens. All exhaust air is HEPA-filtered as it exits the biosafety cabinet, removing harmful bacteria and viruses. This is in contrast to a laminar flow clean bench, which blows unfiltered exhaust air towards the user and is not safe for work with pathogenic agents. Neither are most BSCs safe for use as fume hoods. Likewise, a fume hood fails to provide the environmental protection that HEPA filtration in a BSC would pr ...
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Appliance Classes
Appliance classes (also known as protection classes) specify measures to prevent dangerous contact voltages on unenergized parts, such as the metallic casing, of an electronic device. In the electrical appliance manufacturing industry, the following appliance classes are defined in IEC 61140 and used to differentiate between the protective-earth connection requirements of devices. Class 0 These appliances have no protective-earth connection and feature only a single level of insulation between live parts and exposed metalwork. If permitted at all, Class 0 items are intended for use in dry areas only. A single fault could cause an electric shock or other dangerous occurrence, without triggering the automatic operation of any fuse or circuit breaker. Sales of such items have been prohibited in much of the world for safety reasons, for example in the UK by Section 8 of The Low Voltage Electrical Equipment (Safety) Regulations 1989and New Zealand by thElectricity Act A typical examp ...
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Class II Gaming
The Indian Gaming Regulatory Act (, ''et seq.'') is a 1988 United States federal law that establishes the jurisdictional framework that governs Indian gaming. There was no federal gaming structure before this act. The stated purposes of the act include providing a legislative basis for the operation/regulation of Indian gaming, protecting gaming as a means of generating revenue for the tribes, encouraging economic development of these tribes, and protecting the enterprises from negative influences (such as organized crime). The law established the National Indian Gaming Commission and gave it a regulatory mandate. The law also delegated new authority to the U.S. Department of the Interior and created new federal offenses, giving the U.S. Department of Justice authority to prosecute them. The law has been the source of extensive controversy and litigation. One of the key questions is whether the National Indian Gaming Commission and Department of Interior can be effective in reg ...
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Class II Gene
A class II gene is a type of gene that codes for a protein. Class II genes are transcribed by RNAP II . Class II genes have a promoter that may contain a TATA box In molecular biology, the TATA box (also called the Goldberg–Hogness box) is a sequence of DNA found in the core promoter region of genes in archaea and eukaryotes. The bacterial homolog of the TATA box is called the Pribnow box which has .... Basal transcription of class II genes requires the formation of a preinitiation complex. They are transcribed by RNA polymerase II, include both intron and exon, and code for polypeptide. Major histocompatibility complex (MHC) class II genes are important in the immune response. Major histocompatibility complex (MHC) II is found on antigen-presenting cells (APCs) and functions to present exogenous proteins to CD4+ T cells. MHC II thus plays an important role in activating the immune system in response to extracellular pathogens via activation of CD4+ T cells. MHC ...
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Class II PI 3-kinases
Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation. Class II PI 3-kinases were the most recently identified class of PI 3-kinases. There are three class II PI 3-kinase isoforms expressed in mammalian cells; *PI3K-C2α encoded by the PIK3C2A gene *PI3K-C2β encoded by the PIK3C2B gene *PI3K-C2γ encoded by the PIK3C2G gene See also * Phosphoinositide 3-kinase Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which i ... References *Stein RC (2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment ''Endocr Relat Cancer'' 8:237-24*Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family ''J Cell Sci'' 116:3037 ...
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Class II Railroad
In the United States, railroad carriers are designated as Class I, II, or III, according to annual revenue criteria originally set by the Surface Transportation Board in 1992. With annual adjustments for inflation, the 2019 thresholds were US$504,803,294 for Class I carriers and US$40,384,263 for Class II carriers. (Smaller carriers were Class III by default.) There are seven Class I freight railroad companies in the United States including two Canadian carriers with subsidiary trackage in the United States: BNSF Railway, Canadian National Railway (via its subsidiary Grand Trunk Corporation), Canadian Pacific Railway (via its subsidiary Soo Line Corporation), CSX Transportation, Kansas City Southern Railway, Norfolk Southern Railway, and Union Pacific Railroad. (Mexico's Ferromex and Kansas City Southern de México would qualify as Class I, but do not operate within the United States.) In addition, the national passenger railroad in the United States, Amtrak, would qualify as ...
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Class II Star
A giant star is a star with substantially larger radius and luminosity than a main-sequence (or ''dwarf'') star of the same surface temperature.Giant star, entry in ''Astronomy Encyclopedia'', ed. Patrick Moore, New York: Oxford University Press, 2002. . They lie above the main sequence (luminosity class V in the Yerkes spectral classification) on the Hertzsprung–Russell diagram and correspond to luminosity classes II and III.giant, entry in ''The Facts on File Dictionary of Astronomy'', ed. John Daintith and William Gould, New York: Facts On File, Inc., 5th ed., 2006. . The terms ''giant'' and ''dwarf'' were coined for stars of quite different luminosity despite similar temperature or spectral type by Ejnar Hertzsprung about 1905. Giant stars have radii up to a few hundred times the Sun and luminosities between 10 and a few thousand times that of the Sun. Stars still more luminous than giants are referred to as supergiants and hypergiants. A hot, luminous main-sequence star ...
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MHC Class II
MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses. The antigens presented by class II peptides are derived from extracellular proteins (not cytosolic as in MHC class I). Loading of a MHC class II molecule occurs by phagocytosis; extracellular proteins are endocytosed, digested in lysosomes, and the resulting epitopic peptide fragments are loaded onto MHC class II molecules prior to their migration to the cell surface. In humans, the MHC class II protein complex is encoded by the human leukocyte antigen gene complex (HLA). HLAs corresponding to MHC class II are HLA-DP, HLA-DM, HLA-DOA, HLA-DOB, HLA-DQ, and HLA-DR. Mutations in the HLA gene complex can lead to bare lymphocyte syndrome (BLS), which is a ty ...
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