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Cambridge Antibody Technology
Cambridge Antibody Technology Group Plc, (commonly referred to as CAT) was a biotechnology company headquartered in Cambridge, England. Its core focus was on antibody therapeutics, primarily using phage display, Phage Display and ribosome display, Ribosome Display technology. Phage display, Phage Display Technology was used by CAT to create adalimumab, the first fully human antibody blockbuster drug. Humira, the brand name of adalimumab, is an anti-TNF antibody discovered by CAT as D2E7, then developed in the clinic and marketed by Abbvie, formerly Abbott Laboratories. CAT was also behind belimumab, the anti-BlyS antibody drug marketed as Benlysta and the first new approved drug for systemic lupus in more than 50 years. In 2018, the Nobel Prize organisation awarded one quarter of the Nobel Prize in Chemistry to a founding member of CAT, Greg Winter, Sir Greg Winter FRS "for the phage display of peptides and antibodies". Founded in 1989, CAT was acquired by AstraZeneca for £702 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Public Limited Company
A public limited company (legally abbreviated to PLC or plc) is a type of public company under United Kingdom company law, some Commonwealth of Nations, Commonwealth jurisdictions, and Republic of Ireland, Ireland. It is a limited liability company whose shares may be freely sold and traded to the public (although a PLC may also be privately held, often by another PLC), with a minimum share capital of £50,000 and usually with the letters PLC after its name. Similar companies in the United States are called Public company, ''publicly traded companies''. A PLC can be either an unlisted or listed company on the stock exchanges. In the United Kingdom, a public limited company usually must include the words "public limited company" or the abbreviation "PLC" or "plc" at the end and as part of the legal company name. Welsh companies may instead choose to end their names with , an abbreviation for '. However, some public limited companies (mostly nationalization, nationalised concer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humira
Adalimumab, sold under the brand name Humira and others, is a disease-modifying antirheumatic drug and monoclonal antibody used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis. It is administered by subcutaneous injection (injection under the skin). It works by inactivating tumor necrosis factor-alpha ( TNFα). Common side effects include upper respiratory tract infections, pain at the site of injection, rash, and headache. Other side effects may include serious infections, cancer, anaphylaxis, reactivation of hepatitis B, new onset or exacerbation of demyelinating diseases (such as multiple sclerosis), heart failure, liver failure, and aplastic anemia. Use during pregnancy is not recommended, but some sources show use during breastfeeding may be safe. Adalimumab was approved for medical use in the United States in 2002. It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polysome
A polyribosome (or polysome or ergosome) is a group of ribosomes bound to an mRNA molecule like “beads” on a “thread”. It consists of a complex of an mRNA molecule and two or more ribosomes that act to translate mRNA instructions into polypeptide Peptides are short chains of amino acids linked by peptide bonds. A polypeptide is a longer, continuous, unbranched peptide chain. Polypeptides that have a molecular mass of 10,000 Da or more are called proteins. Chains of fewer than twenty ...s. Originally coined "ergosomes" in 1963, they were further characterized by Jonathan Warner, Paul M. Knopf, and Alex Rich. Polysomes are formed during the elongation phase when ribosomes and elongation factors synthesize the encoded polypeptide. Multiple ribosomes move along the coding region of mRNA, creating a polysome. The ability of multiple ribosomes to function on an mRNA molecule explains the limited abundance of mRNA in the cell. Polyribosome structure differs between p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NASDAQ
The Nasdaq Stock Market (; National Association of Securities Dealers Automated Quotations) is an American stock exchange based in New York City. It is the most active stock trading venue in the U.S. by volume, and ranked second on the list of stock exchanges by market capitalization of shares traded, behind the New York Stock Exchange. The exchange platform is owned by Nasdaq, Inc. (which the exchange also lists; ticker symbol NDAQ), which also owns the Nasdaq Nordic stock market network and several U.S.-based stock and options exchanges. Although it trades stock of healthcare, financial, media, entertainment, retail, hospitality, and food businesses, it focuses more on technology stocks. The exchange is made up of both American and foreign firms, with China and Israel being the largest foreign sources. History 1972–2000 Nasdaq, Inc. was founded in 1971 by the National Association of Securities Dealers (NASD), which is now known as the Financial Industry Regulatory A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
César Milstein
César Milstein, CH, FRS (8 October 1927 – 24 March 2002) was an Argentine biochemist in the field of antibody research. Milstein shared the Nobel Prize in Physiology or Medicine in 1984 with Niels Kaj Jerne and Georges J. F. Köhler for developing the hybridoma technique for the production of monoclonal antibodies. Biography Milstein was born in Bahía Blanca, Argentina. His parents were Máxima (Vanarks) and Lázaro Milstein, a Jewish Ukrainian immigrant. He graduated from the University of Buenos Aires and obtained a PhD under Professor Stopani (Professor of Biochemistry). Later he became a member of the Medical Research Council Laboratory of Molecular Biology, Cambridge, England; he acquired British citizenship and had dual British-Argentinian nationality. In 1956, he received an award from the Sociedad Argentina de Investigation eon Bio Quimica (SAIB) for his work on enzyme kinetics with the enzyme aldehyde dehydrogenase. In 1958, funded by the British Council, he j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Sainsbury, Baron Sainsbury Of Turville
David John Sainsbury, Baron Sainsbury of Turville (born 24 October 1940) is a British politician, businessman and philanthropist. From 1992 to 1997, he served as chairman of Sainsbury's, the supermarket chain established by his great-grandfather John James Sainsbury in 1869. He was made a life peer in 1997 as a member of the Labour Party (UK), Labour Party, and was on a leave of absence from the House of Lords from 15 July 2013 to his retirement in 2021. He served in the government as Parliamentary Under-Secretary of State for Science and Innovation from 1998 and 2006. He is a major donor to the University of Cambridge and, in 2011, was elected Chancellor of the University of Cambridge. He also made the largest donation in British political history, giving £8 million to the Liberal Democrats (UK), Liberal Democrats in 2019. Early life and business career The son of Sir Robert Sainsbury (1906–2000) and Lisa Ingeborg ( van den Bergh; 1912–2014), Sainsbury attended Eton Co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rosalind Franklin
Rosalind Elsie Franklin (25 July 192016 April 1958) was a British chemist and X-ray crystallographer. Her work was central to the understanding of the molecular structures of DNA (deoxyribonucleic acid), RNA (ribonucleic acid), viruses, coal, and graphite. Although her works on coal and viruses were appreciated in her lifetime, Franklin's contributions to the discovery of the structure of DNA were largely unrecognised during her life, for which Franklin has been variously referred to as the "wronged heroine", the "dark lady of DNA", the "forgotten heroine", a "feminist icon", and the "Sylvia Plath of molecular biology". Franklin graduated in 1941 with a degree in Natural Sciences (Cambridge), natural sciences from Newnham College, Cambridge, and then enrolled for a PhD in physical chemistry under Ronald George Wreyford Norrish, the 1920 Chair of Physical Chemistry at the University of Cambridge. Disappointed by Norrish's lack of enthusiasm, she took up a research position und ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science Park
A science park (also called a "university research park", "technology park", "technopark", "technopolis", "technopole", or a "science and technology park" [STP]) is defined as being a property-based development that accommodates and fosters the growth of tenant firms and that are affiliated with a university (or government and private research bodies) based on proximity, ownership, and/or governance. This is so that knowledge can be shared, innovation promoted, technology transferred, and research outcomes progressed to viable commercial products. Science parks are also often perceived as contributing to national economic development, stimulating the formation of new high-technology firms, attracting foreign investment and promoting exports. Background The world's first university research park, Stanford Research Park was launched in 1951 as a cooperative venture between Stanford University and the Palo Alto, California, City of Palo Alto. Another early university research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genome
The human genome is a complete set of nucleic acid sequences for humans, encoded as the DNA within each of the 23 distinct chromosomes in the cell nucleus. A small DNA molecule is found within individual Mitochondrial DNA, mitochondria. These are usually treated separately as the nuclear genome and the Human mitochondrial genetics, mitochondrial genome. Human genomes include both protein-coding DNA sequences and various types of non-coding DNA, DNA that does not encode proteins. The latter is a diverse category that includes DNA coding for non-translated RNA, such as that for ribosomal RNA, transfer RNA, ribozymes, small nuclear RNAs, and several types of RNA#Regulatory RNA, regulatory RNAs. It also includes Promoter (biology), promoters and their associated Cis-regulatory element, gene-regulatory elements, DNA playing structural and replicatory roles, such as Scaffold/matrix attachment region, scaffolding regions, telomeres, centromeres, and Origin of replication, origins of repl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
London Stock Exchange
The London Stock Exchange (LSE) is a stock exchange based in London, England. the total market value of all companies trading on the LSE stood at US$3.42 trillion. Its current premises are situated in Paternoster Square close to St Paul's Cathedral. Since 2007, it has been part of the London Stock Exchange Group (LSEG, which the exchange also lists (ticker symbol LSEG)). Despite a post-Brexit exodus of stock listings from the LSE, it was the most valued stock exchange in Europe as of 2023. According to the 2020 Office for National Statistics report, approximately 12% of UK-resident individuals reported having investments in stocks and shares. According to a 2020 Financial Conduct Authority report, approximately 15% of British adults reported having investments in stocks and shares. History Coffee House The Royal Exchange, London, Royal Exchange had been founded by the English financier Thomas Gresham and Sir Richard Clough on the model of the The Belgian bourse of Antwerp, An ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Babraham Institute
The Babraham Institute is a life sciences research institution focussing on healthy ageing. The Babraham Institute is based on the Babraham Research Campus, partly occupying a former manor house, but also laboratory and science facility buildings on the campus, surrounded by an extensive parkland estate, just south of Cambridge, England. It is an independent and charitable organization which is involved in biomedical research, including healthy aging and molecular biology. The director is Dr Simon Cook who also leads the Institute's signalling research programme. The Babraham Institute is a member of EU-LIFE, an alliance of leading life sciences research centres in Europe. It is also a partner organisation of the University of Cambridge History The institute is located on the historic Babraham Hall Estate (now called the Babraham Research Campus), situated six miles south-east of Cambridge University, near the Gog Magog Hills. It is close to where the ancient Roman Via De ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
