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Bungarotoxin
Bungarotoxins are toxins found in the venom of snakes and kraits. Bites from these animals can result in severe symptoms including bleeding or hemorrhage, paralysis and tissue damage that can result in amputation. The paralytic effects of venom are particularly dangerous as they can impair breathing. These symptoms are the result of bungarotoxin presence in the venom. In actuality, venom contains several distinct bungarotoxins, each varying in which receptors they act on and how powerful they are. History Bungarotoxins are a group of closely related neurotoxic proteins of the three-finger toxin superfamily found in the venom of kraits including '' Bungarus multicinctus'' (the many-banded krait). These toxins alter neurotransmission to yield powerful paralytic effects on skeletal muscle. Venom of the many-banded krait began to be studied by Chuan-Chiung Chang and Chen-Yuan Lee of the National Taiwan University in the 1950s; however, it was not until 1963 that its components were ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Three-finger Toxin
Three-finger toxins (abbreviated 3FTx) are a protein superfamily of small toxin proteins found in the venom of snakes. Three-finger toxins are in turn members of a larger superfamily of three-finger protein domains which includes non-toxic proteins that share a similar protein fold. The group is named for its common structure consisting of three beta strand loops connected to a central core containing four conserved disulfide bonds. The 3FP protein domain has no enzymatic activity and is typically between 60 and 74 amino acid residues long. Despite their conserved structure, three-finger toxin proteins have a wide range of pharmacological effects. Most members of the family are neurotoxins that act on cholinergic intercellular signaling; the alpha-neurotoxin family interacts with muscle nicotinic acetylcholine receptors (nAChRs), the kappa-bungarotoxin family with neuronal nAChRs, and muscarinic toxins with muscarinic acetylcholine receptors (mAChRs). Structure The three-f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors, or nAChRs, are Receptor (biochemistry), receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms. At the neuromuscular junction they are the primary receptor in muscle for motor nerve-muscle communication that controls muscle contraction. In the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the Sympathetic nervous system, sympathetic and parasympathetic nervous system, and (2) they are the receptors found on skeletal muscle that receive acetylcholine released to signal for muscular contraction. In the immune system, nAChRs regulate inflammatory processes and signal through distinct intracellular pathways. In insects, the cholinergic system is limited to the central nervous system. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chuan-Chiung Chang
Chang Chuan-chiung (; 23 October 1928 – 1 February 2024) was a Taiwanese pharmacologist and professor emeritus of pharmacology at National Taiwan University. He is best known for having isolated bungarotoxin, a still-important agent in neurobiological research. Education and career He earned a B.S. from National Taiwan University in 1950, and a Ph.D. at the University of Tokyo in 1965. He later taught at National Taiwan University. Chang Chuan-chiung was elected a member of Academia Sinica in 1976, within the division of life sciences, for his research into the isolation of bungarotoxin. He was the founding editor of the '' Journal of Biomedical Science'', established by Taiwan's National Science Council The National Science and Technology Council (NSTC; ) is a statutory agency of Executive Yuan of the Republic of China (Taiwan) for the promotion and funding of academic research, development of science and technology and science parks. NSTC is ... in January 1994. Ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Krait
''Bungarus'' (commonly known as kraits ) is a genus of venomous snakes in the Family (biology), family Elapidae. The genus is native to Asia. Often found on the floor of tropical forests in South Asia, Southeast Asia and Southern China, they are medium-sized, highly venomous snakes with a total length (including tail) typically not exceeding . These are nocturnal ophiophagy, ophiophagious predators which prey primarily on other snakes at night, occasionally taking lizards, amphibians and rodents. Most species are with banded patterns acting as a aposematism, warning sign to their predators. Despite being considered as generally docile and timid, kraits are capable of delivering highly potent neurotoxins, neurotoxic venom which is medically significant with potential lethality to humans. The genus currently holds 18 species and 5 subspecies. Distribution Kraits are found in tropical and subtropical South Asia, South and Southeast Asia and Indochina, ranging in the west from Iran, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bungarus Multicinctus
''Bungarus'' (commonly known as kraits ) is a genus of venomous snakes in the family Elapidae. The genus is native to Asia. Often found on the floor of tropical forests in South Asia, Southeast Asia and Southern China, they are medium-sized, highly venomous snakes with a total length (including tail) typically not exceeding . These are nocturnal ophiophagious predators which prey primarily on other snakes at night, occasionally taking lizards, amphibians and rodents. Most species are with banded patterns acting as a warning sign to their predators. Despite being considered as generally docile and timid, kraits are capable of delivering highly potent neurotoxic venom which is medically significant with potential lethality to humans. The genus currently holds 18 species and 5 subspecies. Distribution Kraits are found in tropical and subtropical South and Southeast Asia and Indochina, ranging in the west from Iran, east through the Indian subcontinent (including Bangladesh, Nepal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chen-Yuan Lee
Chen-Yuan Lee (; December 4, 1915 – November 1, 2001), was a Taiwanese pharmacologist and political activist. He is famous for his research on snake venom. He was a recipient of the prestigious Redi Award from the International Society on Toxinology (IST), and was also a former president of the society. He was a former dean of the National Taiwan University College of Medicine. After his retirement from researching, he focused on participating in the Taiwan independence movement and many democratic movement. Lee had founded many political organizations such as the "100 Action Union" (100行動聯盟), Foundation of Medical Professionals Alliance in Taiwan. He was also the first chairperson of the Taiwan Independence Party. Early years Lee was born in Takao Prefecture (present-day Kaohsiung), Taiwan in 1915. Both of his parents were from Tainan. Lee chose to become a medical doctor after his father and three of his siblings died of malaria and infectious diseases. L ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bleeding
Bleeding, hemorrhage, haemorrhage or blood loss, is blood escaping from the circulatory system from damaged blood vessels. Bleeding can occur internally, or externally either through a natural opening such as the mouth, nose, ear, urethra, vagina, or anus, or through a puncture in the skin. Hypovolemia is a massive decrease in blood volume, and death by excessive loss of blood is referred to as exsanguination. Typically, a healthy person can endure a loss of 10–15% of the total blood volume without serious medical difficulties (by comparison, blood donation typically takes 8–10% of the donor's blood volume). The stopping or controlling of bleeding is called hemostasis and is an important part of both first aid and surgery. Types * Upper head ** Intracranial hemorrhage — bleeding in the skull. ** Cerebral hemorrhage — a type of intracranial hemorrhage, bleeding within the brain tissue itself. ** Intracerebral hemorrhage — bleeding in the brain caused by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Latin America
Latin America is the cultural region of the Americas where Romance languages are predominantly spoken, primarily Spanish language, Spanish and Portuguese language, Portuguese. Latin America is defined according to cultural identity, not geography, and as such it includes countries in both North and South America. Most countries south of the United States tend to be included: Mexico and the countries of Central America, South America and the Caribbean. Commonly, it refers to Hispanic America plus Brazil. Related terms are the narrower Hispanic America, which exclusively refers to Spanish-speaking nations, and the broader Ibero-America, which includes all Iberic countries in the Americas and occasionally European countries like Spain, Portugal and Andorra. Despite being in the same geographical region, English- and Dutch language, Dutch-speaking countries and territories are excluded (Suriname, Guyana, the Falkland Islands, Jamaica, Trinidad and Tobago, Belize, etc.), and French- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticholinergic
Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central nervous system, central and peripheral nervous system. These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movement of Smooth muscle tissue, smooth muscles present in the gastrointestinal tract, urinary tract, lungs, sweat glands, and many other parts of the body. In broad terms, anticholinergics are divided into two categories in accordance with their specific targets in the central and peripheral nervous system and at the neuromuscular junction: antimuscarinic agents and antinicotinic agents (ganglionic blockers, neuromuscular blockers). The term "anticholinergic" is typically used to refer to antimuscarinics that competitively inhibit the binding of ACh to muscarinic a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antivenom
Antivenom, also known as antivenin, venom antiserum, and antivenom immunoglobulin, is a specific treatment for envenomation. It is composed of antibodies and used to treat certain venomous bites and stings. Antivenoms are recommended only if there is significant toxicity or a high risk of toxicity. The specific antivenom needed depends on the species involved. It is given by injection. Side effects may be severe. They include serum sickness, shortness of breath, and allergic reactions including anaphylaxis. Antivenom is traditionally made by collecting venom from the relevant animal and injecting small amounts of it into a domestic animal. The antibodies that form are then collected from the domestic animal's blood and purified. Versions are available for spider bites, snake bites, fish stings, and scorpion stings. Due to the high cost of producing antibody-based antivenoms and their short shelf lives when not refrigerated, alternative methods of production of antiven ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholine
Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Parts in the body that use or are affected by acetylcholine are referred to as cholinergic. Acetylcholine is the neurotransmitter used at the neuromuscular junction. In other words, it is the chemical that motor neurons of the nervous system release in order to activate muscles. This property means that drugs that affect cholinergic systems can have very dangerous effects ranging from paralysis to convulsions. Acetylcholine is also a neurotransmitter in the autonomic nervous system, both as an internal transmitter for both the sympathetic nervous system, sympathetic and the parasympathetic nervous system, and as the final product released by the parasympathetic nervous system. Acetylcholine is the primary neurotransmitter of the parasympathet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Three-finger Protein
Three-finger proteins or three-finger protein domains (3FP or TFPD) are a protein superfamily consisting of small, roughly 60-80 amino acid residue protein domains with a common tertiary structure: three beta strand loops extended from a hydrophobic core stabilized by disulfide bonds. The family is named for the outstretched "fingers" of the three loops. Members of the family have no enzymatic activity, but are capable of forming protein-protein interactions with high specificity and affinity. The founding members of the family, also the best characterized by structure, are the three-finger toxins found in snake venom, which have a variety of pharmacological effects, most typically by disruption of cholinergic signaling. The family is also represented in non-toxic proteins, which have a wide taxonomic distribution; 3FP domains occur in the extracellular domains of some cell-surface receptors as well as in GPI-anchored and secreted globular proteins, usually involved in signaling. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
