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Bundibugyo Virus
The species ''Bundibugyo ebolavirus'' ( ) is the taxonomic home of one virus, Bundibugyo virus (BDBV), that forms filamentous virions and is closely related to the infamous Ebola virus (EBOV). The virus causes severe disease in humans in the form of viral hemorrhagic fever and is a Select agent, World Health Organization Risk Group 4 Pathogen (requiring Biosafety Level 4-equivalent containment), National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogen, Centers for Disease Control and Prevention Category A Bioterrorism Agent, and is listed as a Biological Agent for Export Control by the Australia Group. Use of term The species ''Bundibugyo ebolavirus'' is a virological taxon (i.e. a man-made concept) that was suggested in 2008 to be included in the genus ''Ebolavirus'', family ''Filoviridae'', order ''Mononegavirales''. The species has a single virus member, Bundibugyo virus (BDBV). The members of the species are called B ...
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Ebola Virus
''Orthoebolavirus zairense'' or Zaire ebolavirus, more commonly known as Ebola virus (; EBOV), is one of six known species within the genus ''Ebolavirus''. Four of the six known ebolaviruses, including EBOV, cause a severe and often fatal viral hemorrhagic fever, hemorrhagic fever in humans and other mammals, known as Ebola virus disease (EVD). Ebola virus has caused the majority of human deaths from EVD, and was the cause of the Western African Ebola virus epidemic, 2013–2016 epidemic in western Africa, which resulted in at least suspected cases and confirmed deaths. Ebola virus and its genus were both originally named for Zaire (now the Democratic Republic of the Congo), the country where it was List of Ebola outbreaks, first described, and was at first suspected to be a new "strain" of the closely related Marburg virus. The virus was renamed "Ebola virus" in 2010 to avoid confusion. Ebola virus is the single member of the species ''Zaire ebolavirus'', which is assigned t ...
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Taxonomy (biology)
In biology, taxonomy () is the science, scientific study of naming, defining (Circumscription (taxonomy), circumscribing) and classifying groups of biological organisms based on shared characteristics. Organisms are grouped into taxon, taxa (singular: taxon), and these groups are given a taxonomic rank; groups of a given rank can be aggregated to form a more inclusive group of higher rank, thus creating a taxonomic hierarchy. The principal ranks in modern use are domain (biology), domain, kingdom (biology), kingdom, phylum (''division'' is sometimes used in botany in place of ''phylum''), class (biology), class, order (biology), order, family (biology), family, genus, and species. The Swedish botanist Carl Linnaeus is regarded as the founder of the current system of taxonomy, having developed a ranked system known as Linnaean taxonomy for categorizing organisms. With advances in the theory, data and analytical technology of biological systematics, the Linnaean system has transfo ...
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Ravn Virus
Ravn virus (; RAVV) is a close relative of Marburg virus (MARV). RAVV causes Marburg virus disease, a form of viral hemorrhagic fever in humans and nonhuman primates. RAVV is a select agent, World Health Organization Risk Group 4 Pathogen (requiring Biosafety Level 4-equivalent containment), National Institutes of Health/ National Institute of Allergy and Infectious Diseases Category A Priority Pathogen, Centers for Disease Control and Prevention Category A Bioterrorism Agent, and listed as a Biological Agent for Export Control by the Australia Group. Use of term Ravn virus (today abbreviated RAVV, but then considered identical to Marburg virus) was first described in 1987 and is named after a 15-year old Danish boy who fell ill and died from it. Today, the virus is classified as one of two members of the species '' Marburg marburgvirus'', which is included into the genus '' Marburgvirus'', family '' Filoviridae'', order '' Mononegavirales''. The name Ravn virus is derived ...
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Marburg Virus
Marburg virus (MARV) is a hemorrhagic fever virus of the '' Filoviridae'' family of viruses and a member of the species '' Marburg marburgvirus'', genus '' Marburgvirus''. It causes Marburg virus disease in primates, a form of viral hemorrhagic fever. The World Health Organization (WHO) rates it as a Risk Group 4 Pathogen (requiring biosafety level 4-equivalent containment). In the United States, the National Institute of Allergy and Infectious Diseases ranks it as a Category A Priority Pathogen and the Centers for Disease Control and Prevention lists it as a Category A Bioterrorism Agent. It is also listed as a biological agent for export control by the Australia Group. The virus can be transmitted by exposure to one species of fruit bats or it can be transmitted between people via body fluids through unprotected sex and broken skin. The disease can cause haemorrhage, fever, and other symptoms similar to Ebola, which belongs to the same family of viruses. According to t ...
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Democratic Republic Of The Congo
The Democratic Republic of the Congo (DRC), also known as the DR Congo, Congo-Kinshasa, or simply the Congo (the last ambiguously also referring to the neighbouring Republic of the Congo), is a country in Central Africa. By land area, it is the List of African countries by area, second-largest country in Africa and the List of countries and dependencies by area, 11th-largest in the world. With a population of around 112 million, the DR Congo is the most populous nominally List of countries and territories where French is an official language, Francophone country in the world. Belgian French, French is the official and most widely spoken language, though there are Languages of the Democratic Republic of the Congo, over 200 indigenous languages. The national capital and largest city is Kinshasa, which is also the economic center. The country is bordered by the Republic of the Congo, the Cabinda Province, Cabinda exclave of Angola, and the South Atlantic Ocean to the west; the Cen ...
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Province Orientale
Orientale Province () is one of the former provinces of the Democratic Republic of the Congo and its predecessors the Congo Free State and the Belgian Congo. It went through a series of boundary changes between 1898 and 2015, when it was divided into smaller units. The District of Orientale Province was created from Stanley Falls District on 15 July 1898. The district was expanded to become Orientale Province in 1913. It was divided in 1933 into Costermansville (later Kivu) and Stanleyville Province. Stanleyville Province was renamed Orientale Province from 1947 to 1963, when it was broken up into Kibali-Ituri, Uélé and Haut-Congo provinces. Orientale Province was reconstituted in 1966. Between 1971 and 1997 it was called Haut-Zaïre, then it returned to the name of Orientale. The province contained the Bas-Uele, Haut-Uele, Ituri and Tshopo districts. These were elevated to provinces in 2015 under the 2006 constitution. The province lay in the northeast of the country. Ori ...
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Ebola Virus Disease
Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after infection. The first symptoms are usually fever, sore throat, Myalgia, muscle pain, and headaches. These are usually followed by vomiting, diarrhoea, rash and decreased liver and kidney function, at which point some people begin to bleeding, bleed both internal bleeding, internally and externally. It kills between 25% and 90% of those infected – about 50% on average. Death is often due to hypovolemic shock, shock from fluid loss, and typically occurs between 6 and 16 days after the first symptoms appear. Early treatment of symptoms increases the survival rate considerably compared to late start.Ebola in Uganda: An Ebola vaccine was approved by the US FDA in December 2019. The virus spreads through direct contact with body fluids, such as bl ...
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Nucleotide
Nucleotides are Organic compound, organic molecules composed of a nitrogenous base, a pentose sugar and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all Life, life-forms on Earth. Nucleotides are obtained in the diet and are also synthesized from common Nutrient, nutrients by the liver. Nucleotides are composed of three subunit molecules: a nucleobase, a pentose, five-carbon sugar (ribose or deoxyribose), and a phosphate group consisting of one to three phosphates. The four nucleobases in DNA are guanine, adenine, cytosine, and thymine; in RNA, uracil is used in place of thymine. Nucleotides also play a central role in metabolism at a fundamental, cellular level. They provide chemical energy—in the form of the nucleoside triphosphates, adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP), and uridine triph ...
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Genome
A genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of junk DNA with no evident function. Almost all eukaryotes have mitochondrial DNA, mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplast DNA, chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been Whole-genome sequencing, sequenced and various regions have been annotated. The first genome to be sequenced was that of the virus φX174 in 1977; the first genome sequence of a prokaryote (''Haemophilus influenzae'') was published in 1995; the yeast (''Saccharomyces cerevisiae'') genome was the first eukaryotic genome to be sequenced in 1996. The Human Genome Project ...
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Article (grammar)
In grammar, an article is any member of a class of dedicated words that are used with noun phrases to mark the identifiability of the referents of the noun phrases. The category of articles constitutes a part of speech. In English language, English, both "the" and "a(n)" are articles, which combine with nouns to form noun phrases. Articles typically specify the grammatical definiteness of the noun phrase, but in many languages, they carry additional grammatical information such as grammatical gender, gender, grammatical number, number, and grammatical case, case. Articles are part of a broader category called determiners, which also include demonstratives, possessive determiners, and Quantifier (linguistics), quantifiers. In linguistic interlinear glossing, articles are list of glossing abbreviations, abbreviated as . Types of article Definite article A definite article is an article that marks a definiteness, definite noun phrase. Definite articles, such as the English ''t ...
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Italic Type
In typography, italic type is a cursive font based on a stylised form of calligraphic handwriting. Along with blackletter and roman type, it served as one of the major typefaces in the history of Western typography. Owing to the influence from calligraphy, italics normally slant slightly to the right, ''like so''. Different glyph shapes from roman type are usually usedanother influence from calligraphyand upper-case letters may have Swash (typography), swashes, flourishes inspired by ornate calligraphy. Historically, italics were a distinct style of type used entirely separately from roman type, but they have come to be used in conjunction—most fonts now come with a roman type and an oblique type, oblique version (generally called "italic" though often not true italics). In this usage, italics are a way to emphasise key points in a printed text, to identify many types of creative works, to cite foreign words or phrases, or, when quoting a speaker, a way to show which w ...
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Capitalization
Capitalization ( North American spelling; also British spelling in Oxford) or capitalisation (Commonwealth English; all other meanings) is writing a word with its first letter as a capital letter (uppercase letter) and the remaining letters in lower case, in writing systems with a case distinction. The term also may refer to the choice of the casing applied to text. Conventional writing systems ( orthographies) for different languages have different conventions for capitalization, for example, the capitalization of titles. Conventions also vary, to a lesser extent, between different style guides. In addition to the Latin script, capitalization also affects the Armenian, Cyrillic, Georgian and Greek alphabets. The full rules of capitalization in English are complicated. The rules have also changed over time, generally to capitalize fewer words. The conventions used in an 18th-century document will be unfamiliar to a modern reader; for instance, many common nouns were capital ...
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