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BPIFA4P
BPI fold containing family A, member 4 (BPIFA4) is a non-human protein encoded by the ''Bpifa4'' gene in mammals such as monkey, cat, and cow but does not appear in rodents and humans. It is also known as Latherin in horse, encoded by the ''Lath/Bpifa4'' gene but is somewhat divergent from the other species. Latherin/BPIFA4 is a secreted protein found in saliva and sweat. In humans, no functional protein is expressed, therefore ''BPIFB4P'' is referred to as a pseudogene. However, a non-functional protein does appear; it known as BASE protein, secreted by breast cancer cell lines and salivary gland tissue (see section below). Superfamily BPIFA3 is a member of a BPI fold protein superfamily defined by the presence of the bactericidal/permeability-increasing protein fold (BPI fold) which is formed by two similar domains in a "boomerang" shape. This superfamily is also known as the BPI/LBP/PLUNC family or the BPI/ LPB/ CETP family. The BPI fold creates apolar binding pockets th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipid-binding Serum Glycoprotein
In molecular biology, the lipid-binding serum glycoproteins family, also known as the BPI/LBP/Plunc family or LBP/BPI/CETP family represents a Protein family, family which includes mammalian lipid-binding Serum (blood), serum glycoproteins and/or proteins containing a structural motif known as the ''BPI fold''. Members of this family include: *Bactericidal/permeability-increasing protein, Bactericidal permeability-increasing protein (BPI) *Lipopolysaccharide-binding protein (LBP) *Cholesterylester transfer protein, Cholesteryl ester transfer protein (CETP) *Phospholipid transfer protein (PLTP) *Plunc, Palate, lung and nasal epithelium carcinoma-associated protein (PLUNC) Structure These proteins consist of N-terminal, N- and C-terminal protein domain, domains, which share a similar two-layer alpha/beta structure, but show little sequence (biology), sequence identity to each other. These domains were first described as being arranged in a "boomerang" shape that creates the BPI ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
