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Asao Hirano
was a Japanese physician, academic, medical researcher and neuropathologist. He is credited with having first observed Hirano bodies which are intracellular aggregates of actin and actin-associated proteins in the neurons (nerve cells). Career Dr. Hirano was a professor of pathology at Albert Einstein College of Medicine. Selected works In a statistical overview derived from writings by and about Asao Hirano, OCLC/WorldCat encompasses roughly 30 works in 50+ publications in 5 languages and 1,000+ library holdings. * ''Electron Microscopic Atlas of Brain Tumors'' (1971), with Tung Pui Poon * ''Atlas of Neuropathology'' (1974), with by Nathan Malamud * ''An Atlas of the Human Brain for Computerized Tomography'' (1978), with Takayoshi Matsui * ''Color Atlas of Pathology of the Nervous System'' (1980) * ''A Guide to Neuropathology'' (1981) * Atlas d'anatomie pathologique du système nerveux (1981) * ''Neuropsychiatric Disorders in the Elderly'' (1983) * ''Praktischer Leitfaden de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuropathology
Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies. Neuropathologists usually work in a department of anatomic pathology, but work closely with the clinical disciplines of neurology, and neurosurgery, which often depend on neuropathology for a diagnosis. Neuropathology also relates to forensic pathology because brain disease or brain injury can be related to cause of death. Neuropathology should not be confused with neuropathy, which refers to disorders of the nerves themselves (usually in the peripheral nervous system) rather than the tissues. In neuropathology, the branches of the specializations of nervous system as well as the tissues come together into one field of study. Methodology The work of the neuropathologist consists largely of examining autopsy or biopsy tissue from the brain and spinal cord to aid in diagnosis of disease. Tissues are also observed through the eyes, muscle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hirano Body
Hirano bodies are intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano in 1965. The eponym ‘Hirano bodies’ was not introduced until 1968, by Schochet ''et al.'', three years after Hirano first observed the proteins. Hirano bodies are found in the nerve cells of individuals afflicted with certain neurodegenerative disorders, such as Alzheimer's disease and Creutzfeldt–Jakob disease. Hirano bodies were first described in the CA1 in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS-PDC). Hirano bodies (Hb) are found mostly in the neuronal processes in the pyramidal layer in the Sommer’s sector (CA1) of the hippocampus, mostly arising from age related changes in the microfilament system. Hirano bodies are often described as rod-shaped, crystal-like, and eosinophilic (pink after staining with haematoxylin and eosin). They are frequently seen in hippocampal pyramidal cells. An e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Montefiore Medical Center
Montefiore Medical Center is a premier academic medical center and the primary teaching hospital of the Albert Einstein College of Medicine in the Bronx, New York City. Its main campus, the Henry and Lucy Moses Division, is located in the Norwood section of the northern Bronx. It is named for Moses Montefiore and is one of the 50 largest employers in New York. In 2020, Montefiore was ranked No. 6 New York City metropolitan area hospitals by '' U.S. News & World Report''. Adjacent to the main hospital is the Children's Hospital at Montefiore, which serves infants, children, teens, and young adults aged 0–21. History The birth of Montefiore Hospital arose from a series of meetings held in early 1884 among representatives of New York City's synagogues, convened by Dr. Henry Pereira Mendes, to honor Sir Moses Montefiore on his forthcoming one-hundredth birthday. Out of these meetings, held in the rooms of Congregation Shearith Israel, the Montefiore Home for Chronic Invalids, no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Einstein College Of Medicine
Albert Einstein College of Medicine is a research-intensive medical school located in the Morris Park neighborhood of the Bronx in New York City. Founded in 1953, Einstein operates as an independent degree-granting institution as part of the integrated health care system, Montefiore Health System (Montefiore Medicine), which includes affiliates such as Jacobi Medical Center. Admission to Einstein is highly competitive, with one of the lowest acceptance rates among medical schools in the United States (3.3% in 2021). Einstein ranks 13th among top U.S. medical schools for graduate success in academic medicine and biomedical research (i.e., awards, publications, grants, and clinical trials), and its NIH funding per investigator consistently ranks among the highest in the nation (7th among US universities in 2019). Einstein offers a M.D. program, a Ph.D. program in the biomedical sciences and clinical investigation, and two Master of Science (M.S.) degrees. In 2021, the MD ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japanese People
The are an East Asian ethnic group native to the Japanese archipelago."人類学上は，旧石器時代あるいは縄文時代以来，現在の北海道〜沖縄諸島（南西諸島）に住んだ集団を祖先にもつ人々。" () Japanese people constitute 97.9% of the population of the country of Japan. Worldwide, approximately 129 million people are of Japanese descent; of these, approximately 122.5 million are residents of Japan. People of Japanese ancestry who live outside Japan are referred to as , the Japanese diaspora. Depending on the context, the term may be limited or not to mainland Japanese people, specifically the Yamato (as opposed to Ryukyuan and Ainu people). Japanese people are one of the largest ethnic groups in the world. In recent decades, there has also been an increase in the number of multiracial people with both Japanese and non-Japanese roots, including half Japanese people. History Theories of origins Archaeological evidence ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of over 100 μM; its mass is roughly 42 kDa, with a diameter of 4 to 7 nm. An actin protein is the monomeric subunit of two types of filaments in cells: microfilaments, one of the three major components of the cytoskeleton, and thin filaments, part of the contractile apparatus in muscle cells. It can be present as either a free monomer called G-actin (globular) or as part of a linear polymer microfilament called F-actin (filamentous), both of which are essential for such important cellular functions as the mobility and contraction of cells during cell division. Actin participates in many important cellular processes, including muscle contraction, cell motility, cell division and cytokinesis, vesicle and organelle movement ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuron
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. Non-animals like plants and fungi do not have nerve cells. Neurons are typically classified into three types based on their function. Sensory neurons respond to stimuli such as touch, sound, or light that affect the cells of the sensory organs, and they send signals to the spinal cord or brain. Motor neurons receive signals from the brain and spinal cord to control everything from muscle contractions to glandular output. Interneurons connect neurons to other neurons within the same region of the brain or spinal cord. When multiple neurons are connected together, they form what is called a neural circuit. A typical neuron consists of a cell body ( soma), dendrites, and a single axon. The soma is a compact structure, and the axo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
OCLC
OCLC, Inc., doing business as OCLC, See also: is an American nonprofit cooperative organization "that provides shared technology services, original research, and community programs for its membership and the library community at large". It was founded in 1967 as the Ohio College Library Center, then became the Online Computer Library Center as it expanded. In 2017, the name was formally changed to OCLC, Inc. OCLC and thousands of its member libraries cooperatively produce and maintain WorldCat, the largest online public access catalog (OPAC) in the world. OCLC is funded mainly by the fees that libraries pay (around $217.8 million annually in total ) for the many different services it offers. OCLC also maintains the Dewey Decimal Classification system. History OCLC began in 1967, as the Ohio College Library Center, through a collaboration of university presidents, vice presidents, and library directors who wanted to create a cooperative, computerized network for librar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WorldCat
WorldCat is a union catalog that itemizes the collections of tens of thousands of institutions (mostly libraries), in many countries, that are current or past members of the OCLC global cooperative. It is operated by OCLC, Inc. Many of the OCLC member libraries collectively maintain WorldCat's database, the world's largest bibliographic database. The database includes other information sources in addition to member library collections. OCLC makes WorldCat itself available free to libraries, but the catalog is the foundation for other subscription OCLC services (such as resource sharing and collection management). WorldCat is used by librarians for cataloging and research and by the general public. , WorldCat contained over 540 million bibliographic records in 483 languages, representing over 3 billion physical and digital library assets, and the WorldCat persons dataset ( mined from WorldCat) included over 100 million people. History OCLC was founded in 1967 under the lea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Order Of The Rising Sun
The is a Japanese order, established in 1875 by Emperor Meiji. The Order was the first national decoration awarded by the Japanese government, created on 10 April 1875 by decree of the Council of State. The badge features rays of sunlight from the rising sun. The design of the Rising Sun symbolizes energy as powerful as the rising sunEmbassy of Japan in Australia in parallel with the "rising sun" concept of Japan ("Land of the Rising Sun"). The Order of the Rising Sun is awarded to people who have rendered distinguished service to the state in various fields except military service. Since there is no order for military achievements under the current Japanese system, |
National Institutes Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research ins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Neurological Diseases And Blindness
The National Institute of Neurological Disorders and Stroke (NINDS) is a part of the U.S. National Institutes of Health (NIH). It conducts and funds research on brain and nervous system disorders and has a budget of just over US$2.03 billion. The mission of NINDS is "to reduce the burden of neurological disease—a burden borne by every age group, every segment of society, and people all over the world". NINDS has established two major branches for research: an extramural branch that funds studies outside the NIH, and an intramural branch that funds research inside the NIH. Most of NINDS' budget goes to fund extramural research. NINDS' basic science research focuses on studies of the fundamental biology of the brain and nervous system, genetics, neurodegeneration, learning and memory, motor control, brain repair, and synapses. NINDS also funds clinical research related to diseases and disorders of the brain and nervous system, e.g. AIDS, Alzheimer's disease, epilepsy, muscular d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
