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Alexander Schmidt (physiologist)
Hermann Adolf Alexander Schmidt ( – ) was a Baltic German physiologist from what was then the Governorate of Livonia in the Russian Empire. He was born on the island of Moon, which is today known by its Estonian name Muhu, in present-day Estonia. In 1858, he received his medical doctorate from the University of Dorpat, and later was an assistant to Felix Hoppe-Seyler (1825-1895) in Berlin, and to Carl Ludwig (1816-1895) in Leipzig. In 1869 he succeeded Friedrich Bidder (1810-1894) as professor of physiology at Dorpat, where he remained for the rest of his life. From 1885 to 1889 he served as university rector. Schmidt is remembered for his research involving the process of blood coagulation by demonstrating that the transformation of fibrinogen into fibrin was the result of an enzymatic process. He named the hypothetical enzyme "thrombin", and he called its precursor "prothrombin". Schmidt is credited for providing a foundation for the creation of anti-coagulation systems ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liiva, Muhu Parish
Liiva is a village on the Estonian island Muhu. (retrieved 28 July 2021) It is the administrative centre of Muhu Parish in Saare County and also is the largest village in the municipality with a population of 189 (as of 1 January 2012). Liiva is situated in the heart of the island by the main road (segment of the Risti–Kuressaare road, nr 10). Liiva is the location of the Early Gothic Muhu St. Catherine's Church from the 13th century. Not far from the church there is a rectory from 1832, where a famous physiologist, founder of the coagulation Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a thrombus, blood clot. It results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The process of co ... theory Alexander Schmidt was born. Liiva is home to the Muhu Primary School with about 100 pupils. There's also a library, supermarket (Konsum), post office and a pharmacy in the villa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Felix Hoppe-Seyler
Ernst Felix Immanuel Hoppe-Seyler (''né'' Felix Hoppe; 26 December 1825 – 10 August 1895) was a German physiologist and chemist, and the principal founder of the disciplines of biochemistry and molecular biology. He had discovered Yeast nucleic acid which is now called RNA in his attempts to follow up and confirm Miescher's results by repeating parts of Miescher's experiments. He took the name Hoppe-Seyler family, Seyler when he was adopted by his brother-in-law, a grandson of the famous theatre principal Abel Seyler. Biography Hoppe-Seyler was born in Freyburg, Germany, Freyburg an der Unstrut in the Province of Saxony. He originally trained to be a physician in University of Halle-Wittenberg, Halle and University of Leipzig, Leipzig, and received his medical doctorate from Humboldt University of Berlin, Berlin in 1851. Afterwards, he was an assistant to Rudolf Virchow at the pathology, Pathological Institute in Berlin. Hoppe-Seyler preferred scientific research to medicine, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Transfusion
Blood transfusion is the process of transferring blood products into a person's Circulatory system, circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern medical practice commonly uses only components of the blood, such as red blood cells, blood plasma, plasma, platelets, and other clotting factors. White blood cells are transfused only in very rare circumstances, since granulocyte transfusion has limited applications. Whole blood has come back into use in the Major trauma, trauma setting. Red blood cells (RBC) contain hemoglobin and supply the Cell (biology), cells of the body with oxygen. White blood cells are not commonly used during transfusions, but they are part of the immune system and also fight infections. Plasma is the "yellowish" liquid part of blood, which acts as a buffer and contains proteins and other important substances needed for the body's overall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prothrombin
Prothrombin (coagulation factor II) is encoded in the human by the F2-gene. It is proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin. Thrombin (Factor IIa) (, fibrose, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, that converts fibrinogen into strands of insoluble fibrin, as well as catalyzing many other coagulation-related reactions. History After the description of fibrinogen and fibrin, Alexander Schmidt hypothesised the existence of an enzyme that converts fibrinogen into fibrin in 1872. Prothrombin was discovered by Pekelharing in 1894. Physiology Synthesis Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). The activity of factor Xa is greatly enhanced by binding to activated Factor V (Va), termed the prothrombinase complex. Prothrombin is prod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecules known as product (chemistry), products. Almost all metabolism, metabolic processes in the cell (biology), cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme, pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts include Ribozyme, catalytic RNA molecules, also called ribozymes. They are sometimes descr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibrin
Fibrin (also called Factor Ia) is a fibrous protein, fibrous, non-globular protein involved in the Coagulation, clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerization, polymerize. The polymerized fibrin, together with platelets, forms a hemostasis, hemostatic plug or clot over a wound site. When the lining of a blood vessel is broken, platelets are attracted, forming a platelet plug. These platelets have thrombin receptors on their surfaces that bind serum thrombin molecules, which in turn convert soluble fibrinogen in the serum into fibrin at the wound site. Fibrin forms long strands of tough insoluble protein that are bound to the platelets. Factor XIII completes the cross-linking of fibrin so that it hardens and contracts. The cross-linked fibrin forms a mesh atop the platelet plug that completes the clot. Fibrin was discovered by Marcello Malpighi in 1666. Role in disease Excessive generation of fibrin due ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibrinogen
Fibrinogen (coagulation factor I) is a glycoprotein protein complex, complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted Enzyme, enzymatically by thrombin to fibrin and then to a fibrin-based Thrombus, blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, Capillary action, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing. Reduced and/or dysfunctional fibrinogens occur in various congenital and acquired human List of fibrinogen disorders, fibrinogen-related disorders. These disorders represent a group of rare conditions in which individuals may present with severe episodes of pathological bleed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Coagulation
Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The process of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. Coagulation begins almost instantly after an injury to the endothelium that lines a blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial platelet tissue factor to coagulation factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called ''primary hemostasis. Secondary hemostasis'' occurs simultaneously: additional coagulation factors beyond factor VII ( listed below) respond in a cascade to form fibrin strands, which strengthen the platelet plug. Coagulation is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Who Named It
''Whonamedit?'' is an online English-language dictionary of medical eponyms and the people associated with their identification. Though it is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliographies. The dictionary is hosted in Norway Norway, officially the Kingdom of Norway, is a Nordic countries, Nordic country located on the Scandinavian Peninsula in Northern Europe. The remote Arctic island of Jan Mayen and the archipelago of Svalbard also form part of the Kingdom of ... and was developed by medical historian Ole Daniel Enersen. References External links * Medical websites Medical dictionaries Eponyms in medicine {{online-dict-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rector (academia)
A rector (Latin language, Latin for 'ruler') is a senior official in an educational institution, and can refer to an official in either a university or a secondary school. Outside the English-speaking world, the rector is often the most senior official in a university, while in the United States, the equivalent is often referred to as the President (education), president, and in the United Kingdom and Commonwealth of Nations, the equivalent is the Vice-chancellor (education), vice-chancellor. The term and office of a rector can be referred to as a rectorate. The title is used widely in universities in EuropeEuropean nations where the word ''rector'' or a cognate thereof (''rektor'', ''recteur'', etc.) is used in referring to university administrators include Albania, Austria, Benelux, the Benelux, Bosnia and Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, Germany, Greece, Hungary, Iceland, Italy, Latvia, Malta, Moldova, North Macedonia, Poland, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Friedrich Bidder
Georg Friedrich Karl Heinrich Bidder ( – ) was a Baltic German physiologist and anatomist from what was then the Governorate of Livonia in the Russian Empire. In 1834 he received his doctorate from the University of Dorpat, where he became a professor of anatomy (1842), and physiology and pathology (1843). He was a corresponding member (1857) and honorary member (1884) of the Saint Petersburg Academy of Sciences (today Russian Academy of Sciences). He was the president of the Naturalists' Society at the University of Dorpat from 1877 to 1890. Bidder is primarily remembered for his studies of nutrition and gastric physiology. From 1847 to 1852 he performed physiological-chemical studies of digestive juices and metabolism with chemist Carl Ernst Heinrich Schmidt (1822–1894). He also conducted important investigations of the sympathetic nervous system with Alfred Wilhelm Volkmann (1801–1877) and of the spinal cord with Karl Wilhelm von Kupffer (1829–1902). Bidder's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
