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ATF7
Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ''ATF7'' gene. Homonym In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, Protein-protein interaction, interacts with PTP4A1. This ATF-7 is actually ATF5 and not ATF7, as noted by the authors at the end of their paper ("Note Added in Proof—While this manuscript was under review, sequences for mouse and human ATF-5 were deposited in GenBankTM. It appears that ATF-7 and ATF-5 are likely to be the same protein. In addition, an unrelated sequence named ATF7 has also been deposited in GenBankTM. In order to avoid confusion, future work on the protein described in this publication will likely refer to it as either ATF-5 or ATF-5/7.") References Further reading * * * * * * * * * * External links * * Transcription factors {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PTP4A1
Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the ''PTP4A1'' gene. The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. Interactions PTP4A1 has been shown to Protein-protein interaction, interact with ATF7. References Further reading * * * * * * * * * * * * * * * * * * * {{gene-6-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid resid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ATF5
Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ''ATF5'' gene. Function First described by Nishizawa and Nagata, ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family. ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types. ATF5 expression is regulated at both the transcriptional and translational level. ATF5 is expressed in VZ and SVZ during brain development. The human ATF5 protein is made up of 282 amino acids. ATF5 is a transcription factor that contains a bZip domain. See also * Activating transcription factor Interactions ATF5 has been shown to interact with DISC1 and TRIB3 Tribbles homolog 3 is a protein that in humans is encoded by the ''TRIB3'' gene. Function The protein encoded by this gene is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
