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4-HO-DET
4-HO-DET, also known as 4-hydroxy-''N'',''N''-diethyltryptamine as well as ethocin or CZ-74, is a psychedelic drug of the tryptamine family. It is a substituted tryptamine, structurally related to psilocin, ethocybin, and 4-HO-DIPT. Use ''TiHKAL'' reports moderate effects at 10 to 25mg ingested orally. Effects 4-HO-DET produces psychedelic effects similar to psilocybin. Its duration is 4 to 6hours. Interactions Pharmacology The pharmacology of 4-HO-DET has been studied. Chemistry Analogues 4-HO-DET is the N,N-diethyl analog of psilocin. The acetic acid ester of 4-HO-DET is known as 4-AcO-DET and the phosphoric acid ester of 4-HO-DET is known as 4-phosphoryloxy-DET, CEY-19, or ethocybin. These compounds may likely be prodrugs of 4-HO-DET as has been shown with the acetate and phosphate esters of other methylated tryptamines such as psilocin. History 4-HO-DET received the lab code CZ-74 in the late 1950s by the inventors of the substance, Albert Hofmann and Franz Troxler. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethocybin
Ethocybin (code name CEY-19), also known as 4-phosphoryloxy-''N'',''N''-diethyltryptamine (4-PO-DET), is a homologue of the mushroom alkaloid psilocybin, and a semi-synthetic psychedelic alkaloid of the tryptamine family. Pharmacology Ethocybin may be dephosphorylated in vivo to 4-HO-DET (ethocin), analogously to how psilocybin is metabolized to psilocin. This chemical reaction takes place under strongly acidic conditions or enzymatically by phosphatases in the body. 4-HO-DET acts as a partial agonist at the 5-HT2A serotonin receptor. History Albert Hofmann was the first to produce ethocybin, soon after his discovery of psilocin and psilocybin. It was first described by 1963. The drug was known under the code name CEY-19. Legal status United States Ethocybin is not controlled in the United States, but possession or sale may be considered illegal under the Federal Analog Act. Research Ethocybin has been studied as a treatment for several disorders since the early 1960s, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychedelic Drug
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic hallucinogens or serotonergic hallucinogens, the term ''psychedelic'' is sometimes used more broadly to include various other types of hallucinogens as well, such as those which are atypical or adjacent to psychedelia like salvia and MDMA, respectively. Classic psychedelics generally cause specific psychological, visual, and auditory changes, and oftentimes a substantially altered state of consciousness. They have had the largest influence on science and culture, and include mescaline, LSD, psilocybin, and DMT. There are a large number of both naturally occurring and synthetic serotonergic psychedelics. Most psychedelic drugs fall into one of the three families of chemical compounds: tryptamines, phenethylamines, or lysergamides. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-AcO-DET
4-AcO-DET, also known as 4-acetoxy-''N'',''N''-diethyltryptamine as well as ethacetin or ethylacybin, is a psychedelic tryptamine. It was first synthesized in 1958 by Albert Hofmann in the Sandoz lab.Erowid 4-Acetoxy-DET Vaults : Primer Accessed on April 19, 2007. Use and effects 4-Acetoxy-DET is orally active, and dosages of 10–25 mg are common. Effects last 4–6 hours. The free base is also active when smoked in a dose range of 5–20 mg. Smoking 4-acetoxy-DET greatly speeds up the onset; |
Serotonergic Psychedelic
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic hallucinogens or serotonergic hallucinogens, the term ''psychedelic'' is sometimes used more broadly to include various other types of hallucinogens as well, such as those which are atypical or adjacent to psychedelia like salvia and MDMA, respectively. Classic psychedelics generally cause specific psychological, visual, and auditory changes, and oftentimes a substantially altered state of consciousness. They have had the largest influence on science and culture, and include mescaline, LSD, psilocybin, and DMT. There are a large number of both naturally occurring and synthetic serotonergic psychedelics. Most psychedelic drugs fall into one of the three families of chemical compounds: tryptamines, phenethylamines, or lysergamides. They pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychedelic Drug
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic hallucinogens or serotonergic hallucinogens, the term ''psychedelic'' is sometimes used more broadly to include various other types of hallucinogens as well, such as those which are atypical or adjacent to psychedelia like salvia and MDMA, respectively. Classic psychedelics generally cause specific psychological, visual, and auditory changes, and oftentimes a substantially altered state of consciousness. They have had the largest influence on science and culture, and include mescaline, LSD, psilocybin, and DMT. There are a large number of both naturally occurring and synthetic serotonergic psychedelics. Most psychedelic drugs fall into one of the three families of chemical compounds: tryptamines, phenethylamines, or lysergamides. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Tryptamine
Substituted tryptamines, or simply tryptamines, also known as serotonin analogues (i.e., 5-hydroxytryptamine analogues), are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino group, amino (NH2) group via an ethyl (−CH2–CH2−) side chain, sidechain. In substituted tryptamines, the indole ring, sidechain, and/or amino group are modified by substituting another group for one of the hydrogen (H) atoms. Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle. Tryptamine alkaloids are found in fungi, plants and animals; and sometimes used by humans for the neurological or psychotropic effects of the substance. Prominent examples of tryptamine alkaloids include psilocybin (from "psilocybin mushrooms") and dimethyltryptamine, DMT. In South America, dimethyltryptamine is obtained f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TiHKAL
''TiHKAL: The Continuation'' is a 1997 book written by Alexander Shulgin and Ann Shulgin about a family of psychoactive drugs known as tryptamines. A sequel to '' PiHKAL: A Chemical Love Story'', ''TiHKAL'' is an acronym that stands for "Tryptamines I Have Known and Loved". Content ''TIHKAL'', much like its predecessor ''PIHKAL'', is divided into two parts. The first part, for which all rights are reserved, begins with a fictionalized autobiography, picking up where the similar section of ''PIHKAL'' left off; it then continues with a collection of essays on topics ranging from psychotherapy and the Jungian mind to the prevalence of DMT in nature, ayahuasca and the War on Drugs. The second part of ''TIHKAL'', which may be conditionally distributed for non-commercial reproduction , is a detailed synthesis manual for 55 psychedelic compounds (many discovered by Alexander Shulgin himself), including their chemical structures, dosage recommendations, and qualitative comments. Shul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-HO-DIPT
4-HO-DiPT, also known as 4-hydroxy-''N'',''N''-diisopropyltryptamine or as iprocin, is a synthetic compound, synthetic psychedelic drug of the substituted tryptamine, tryptamine family. It is a higher homologous series, homologue of psilocin and 4-HO-DET and is a positional isomer of 4-HO-DPT. Use and dosage In ''TiHKAL'', Alexander Shulgin reported that 4-HO-DiPT had a dose range of 15 to 20mg oral administration, orally and a duration of action, duration of 2 to 3hours. However, a wider recreational drug, recreational dose range of 3 to 30mg or more orally has also been reported. The drug is active at around 3mg and above, and its effects last for 2 to 3hours. Shulgin has stated that 4-HO-DiPT has an especially steep dose–response curve and narrow dose range, with doses below 10mg having few to no effects and there having been no trials above 20mg due to the intensity of its effects. Effects The effects of 4-HO-DiPT are broadly comparable to those of other serotonergic psych ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prodrug
A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted (ADME). Prodrugs are often designed to improve bioavailability when a drug itself is poorly absorbed from the gastrointestinal tract. A prodrug may be used to improve how selectively the drug interacts with cells or processes that are not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. History Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, sal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphoric Acid
Phosphoric acid (orthophosphoric acid, monophosphoric acid or phosphoric(V) acid) is a colorless, odorless phosphorus-containing solid, and inorganic compound with the chemical formula . It is commonly encountered as an 85% aqueous solution, which is a colourless, odourless, and non- volatile syrupy liquid. It is a major industrial chemical, being a component of many fertilizers. The compound is an acid. Removal of all three ions gives the phosphate ion . Removal of one or two protons gives dihydrogen phosphate ion , and the hydrogen phosphate ion , respectively. Phosphoric acid forms esters, called organophosphates. The name "orthophosphoric acid" can be used to distinguish this specific acid from other " phosphoric acids", such as pyrophosphoric acid. Nevertheless, the term "phosphoric acid" often means this specific compound; and that is the current IUPAC nomenclature. Production Phosphoric acid is produced industrially by one of two routes, wet processes and dry. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Franz Troxler
Franz may refer to: People * Franz (given name) * Franz (surname) Places * Franz (crater), a lunar crater * Franz, Ontario, a railway junction and unorganized town in Canada * Franz Lake, in the state of Washington, United States – see Franz Lake National Wildlife Refuge Businesses * Franz Deuticke, a scientific publishing company based in Vienna, Austria * Franz Family Bakeries, a food processing company in Portland, Oregon * Franz-porcelains, a Taiwanese brand of pottery based in San Francisco Other uses * ''Franz'' (1971 film), a Belgian film * Franz (2025 film), an upcoming biographical film of Franz Kafka * Franz Lisp, a dialect of the Lisp programming language See also * Frantz (other) * Franzen (other) * Frantzen (other) Frantzen or Frantzén is a surname. Notable people with the surname include: * Allen Frantzen (born 1947/48), American medievalist * Björn Frantzén (born 1977), Swedish chef and restaurateur * Jean-Pierre Fran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Hofmann
Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann's team also isolated, named and synthesized the principal psychedelic mushroom compounds psilocybin and psilocin. He authored more than 100 scientific articles and numerous books, including ''LSD: Mein Sorgenkind'' (''LSD: My Problem Child''). In 2007, he shared first place with Tim Berners-Lee on a list of the 100 greatest living geniuses published by ''The Daily Telegraph'' newspaper. Early life and education Albert Hofmann was born in Baden, Switzerland, on 11 January 1906. He was the first of four children to factory toolmaker Adolf Hofmann and Elisabeth ( Schenk) and was baptized Protestant. When his father became ill, Hofmann obtained a position as a commercial apprentice in concurrence with his studies. Owing to his father's low income, Albert's godfather paid for his e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
