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Α,N,N,O-TeMS
α,''N'',''N'',''O''-Tetramethylserotonin (α,''N'',''N'',''O''-TeMS), also known as 5-methoxy-α,''N'',''N''-trimethyltryptamine (5-MeO-α,''N'',''N''-TMT), is a little-known synthetic compound of the tryptamine, α-alkyltryptamine, and 5-methoxytryptamine families. It is the combined derivative of α-methyltryptamine (αMT) and 5-methoxy-''N'',''N''-dimethyltryptamine (5-MeO-DMT). The drug was described by Alexander Shulgin in his book ''TiHKAL'' (''Tryptamines I Have Known and Loved'') as a putative psychedelic drug. However, Shulgin does not appear to have ever synthesized or assayed it. As such, α,''N'',''N'',''O''-TeMS's effects, dosage, and duration are all unknown. α,''N'',''N'',''O''-TeMS is also the ''N'',''N''- dimethylated derivative of 5-methoxy-α-methyltryptamine (5-MeO-αMT or α,''O''-DMS) and the ''N''-methylated derivative of 5-methoxy-α,''N''-dimethyltryptamine (5-MeO-α,''N''-DMT or α,''N'',''O''-TMS). 5-MeO-α,''N''-DMT is less potent and long-l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthetic Compound
Some chemical authorities define an organic compound as a chemical compound that contains a carbon–hydrogen or carbon–carbon bond; others consider an organic compound to be any chemical compound that contains carbon. For example, carbon-containing compounds such as alkanes (e.g. methane ) and its derivatives are universally considered organic, but many others are sometimes considered inorganic, such as certain compounds of carbon with nitrogen and oxygen (e.g. cyanide ion , hydrogen cyanide , chloroformic acid , carbon dioxide , and carbonate ion ). Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The study of the properties, reactions, and syntheses of organic compounds comprise the discipline known as organic chemistry. For historical reasons, a few classes of carbon-containing compounds (e.g., carbonate salts and cyanide salts), along with a few other exceptions (e.g., carbon dioxide, and even hydrogen cy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methyl Group
In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms, having chemical formula (whereas normal methane has the formula ). In formulas, the group is often abbreviated as Me. This hydrocarbon group occurs in many organic compounds. It is a very stable group in most molecules. While the methyl group is usually part of a larger molecule, bonded to the rest of the molecule by a single covalent bond (), it can be found on its own in any of three forms: methanide anion (), methylium cation () or methyl radical (). The anion has eight valence electrons, the radical seven and the cation six. All three forms are highly reactive and rarely observed. Methyl cation, anion, and radical Methyl cation The methylium cation () exists in the gas phase, but is otherwise not encountered. Some compounds are considered to be sources of the cation, and this simplification is used pervasively in organic chemistry. For ex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-Alkyltryptamines
Substituted tryptamines, or simply tryptamines, also known as serotonin analogues (i.e., 5-hydroxytryptamine analogues), are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino group, amino (NH2) group via an ethyl (−CH2–CH2−) side chain, sidechain. In substituted tryptamines, the indole ring, sidechain, and/or amino group are modified by substituting another group for one of the hydrogen (H) atoms. Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle. Tryptamine alkaloids are found in fungi, plants and animals; and sometimes used by humans for the neurological or psychotropic effects of the substance. Prominent examples of tryptamine alkaloids include psilocybin (from "psilocybin mushrooms") and dimethyltryptamine, DMT. In South America, dimethyltryptamine is obtained f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Analog
A structural analog, also known as a chemical analog or simply an analog, is a chemical compound, compound having a chemical structure, structure similar to that of another compound, but differing from it in respect to a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound. Structural analogs are often isoelectronicity, isoelectronic. Despite a high chemical similarity, structural analogs are not necessarily functional analog (chemistry), functional analogs and can have very different physical, chemical, biochemical, or pharmacological properties. In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study or a database is virtual screening, screened for structural analogs of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isotryptamine
Isotryptamine, also known as 2-(1-indolyl)ethylamine, is a chemical compound and positional isomer of tryptamine (2-(3-indolyl)ethylamine). A variety of isotryptamine chemical derivative, derivatives, or chemical substituent, substituted isotryptamines, have been developed, including serotonergic psychedelics and psychoplastogens like 6-MeO-isoDMT; non-hallucinogenic psychoplastogens like isoDMT, 5-MeO-isoDMT, and zalsupindole (DLX-001; AAZ-A-154); serotonin 5-HT2C receptor, 5-HT2C receptor agonists like 5,6-difluoro-isoAMT, (''S'')-5,6-difluoro-isoAMT, Ro60-0175 ((''S'')-5-fluoro-6-chloro-isoAMT), and PNU-181731; serotonin 5-HT6 receptor, 5-HT6 receptor receptor modulator, modulators; and dual monoamine releasing agents and serotonin receptor agonists like α-methylisotryptamine, isoAMT (PAL-569). JRT (drug), JRT is the isotryptamine analogue of LSD and may be considered a cyclic compound, cyclized isotryptamine. References Isotryptamines, Serotonin receptor modulato ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zalsupindole
Zalsupindole,https://iris.who.int/bitstream/handle/10665/380497/9789240107038-eng.pdf "zalsupindolum zalsupindole (2R)-1-(5-methoxy-1H-indol-1-yl)-N,N-dimethylpropan-2-amine antidepressant" also known by its developmental code names DLX-001 and AAZ-A-154 and as (''R'')-5-methoxy-''N'',''N''-dimethyl-α-methylisotryptamine, is a novel isotryptamine derivative which acts as a serotonin 5-HT2A receptor agonist discovered and synthesized by the lab of Professor David E. Olson at the University of California, Davis. It is being developed for the treatment of major depressive disorder and other central nervous system disorders. Pharmacology Animal studies suggest that it produces antidepressant effects without the psychedelic action typical of drugs from this class. In tests, zalsupindole had antidepressant-like effects in mice without causing the head-twitch response linked to hallucinogenic effects. Due to the rapidly-induced and enduring neuroplasticity, zalsupindole is a member ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
α,N,N-Trimethyltryptamine
α,''N'',''N''-Trimethyltryptamine (α,''N'',''N''-TMT, α-TMT, or ATMT), also known as α-methyl-''N'',''N''-dimethyltryptamine (α-methyl-DMT or α-Me-DMT), as well as Alpha-N, is a psychedelic drug of the tryptamine family. It is similar in structure to other psychoactive tryptamines such as ''N'',''N''-dimethyltryptamine (DMT) and α-methyltryptamine (αMT). The drug has been tested in animals and compared with αMT. It was found to produce similar effects, such as hyperlocomotion and reversal of reserpine-induced behavioral depression, but with only around half the potency of αMT. α,''N'',''N''-TMT was briefly mentioned by Alexander Shulgin in his 1997 book ''TiHKAL'' (''Tryptamines I Have Known and Loved''), but he did not mention having tested it and did not describe its effects, dosage, or duration. In 2025, Hamilton Morris described having synthesized and assayed α,''N'',''N''-TMT. He reported that it was an active psychedelic taken orally but was much less po ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edgewood Arsenal
Aberdeen Proving Ground (APG) is a U.S. Army facility located adjacent to Aberdeen, Harford County, Maryland, United States. More than 7,500 civilians and 5,000 military personnel work at APG. There are 11 major commands among the tenant units, including: * United States Army Communications-Electronics Command (CECOM) * United States Army Combat Capabilities Development Command (CCDC) * United States Army Test and Evaluation Command (ATEC) * Edgewood Arsenal * Adelphi Laboratory Center ** The Army Reserve Information Operations Command ** Unified Cross Domain Services Management Office ** HQ, U.S. Army Contracting Command (Army Contracting Command –APG, Adelphi Contracting Division) ** U.S. Army 93rd Signal Network - Network Enterprise Center ** Logistics Readiness Center ** U.S. Army Cyber Operation Group – 335th Signal Command ** Blossom Point Research Facility History APG is the U.S. Army's oldest active proving ground, established on October 20, 1917, six months aft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Potency (pharmacology)
In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. A highly potent drug (e.g., fentanyl, clonazepam, risperidone, benperidol, bumetanide) evokes a given response at low concentrations, while a drug of lower potency (e.g. morphine, alprazolam, ziprasidone, haloperidol, furosemide) evokes the same response only at higher concentrations. Higher potency does not necessarily mean greater effectiveness nor more side effects nor less side effects. Types of potency The International Union of Basic and Clinical Pharmacology (IUPHAR) has stated that "potency is an imprecise term that should always be further defined", and lists of types of potency as follows: Miscellaneous Lysergic acid diethylamide (LSD) is one of the most potent psychoactive drug A psychoactive drug, psychopharmaceutical, mind-altering drug, consciousness-altering drug, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
