NADP+

NADP

In general, NADP is synthesized before NADPH is. Such a reaction usually starts with NAD from either the de-novo or the salvage pathway, with NAD kinase adding the extra phosphate group. ADP-ribosyl cyclase allows for synthesis from nicotinamide in the salvage pathway, and NADP phosphatase can convert NADPH back to NADH to maintain a balance. Some forms of the NAD kinase, notably the one in mitochondria, can also accept NADH to turn it directly into NADPH. The prokaryotic pathway is less well understood, but with all the similar proteins the process should work in a similar way.