Autosomes

Humans

Autosomes still contain sexual determination genes even though they are not sex chromosomes. For example, mutations of the SOX9 gene on chromosome 17 can cause humans with a typical Y chromosome to develop as females. The transcription factor TDF (encoded by the SRY gene on the Y sex chromosome), a protein vital for male sex determination during development, functions by activating SOX9 and that the mutation on SOX9 causes the gene to be activated without the TDR transcription factor.