1944 World Series

As both teams called Sportsman's Park home, the traditional 2–3–2 home field assignment was used (instead of the wartime 3–4). The Junior World Series of that same year, partly hosted in Baltimore's converted football stadium, easily outdrew the "real" Series and attracted attention to Baltimore as a potential major league city. Ten years later, the Browns relocated there and became the Orioles. The Orioles would go on to win the 1966 World Series, becoming the last of the AL's eight charter franchises to do so. Another all-Missouri World Series was played 41 years later, with the Kansas City Royals defeating the Cardinals in seven games.

The Series was also known as the "Trolley Series," "Streetcar Series," or the "St. Louis Showdown." Coincidentally, this World Series was played the same year Metro-Goldwyn-Mayer released the musical film Meet Me in St. Louis. It remains one of two World Series played that featured two teams from the same city other than New York; the other was the 1906 World Series between the two Chicago teams. The 1989 World Series featured two teams from the San Francisco metropolitan area, but not the same city. It was also the first World Series in which both teams played west of the Mississippi River.

This is currently the earliest World Series in which one of the teams (St. Louis Browns), has had no personnel eventually elected to the Hall of Fame.

To date, the St. Louis Cardinals of 1942, 1943, and 1944 are the most recent National League team to appear in the World Series in three consecutive seasons.

This is the only World Series to date in which neither team was credited with a stolen base.

This would also be the final World Series where Kenesaw Mountain Landis was the commissioner of baseball. Landis died six weeks later on November 25.

This was the only time the Baltimore Orioles franchise made the World Series (and by extension the postseason) while based in St. Louis. The next time they did either was in 1966, by which time the franchise had relocated to Baltimore.