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Codeine

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Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. It is commonly used as a recreational drug. It is found naturally in the sap of the opium poppy, Papaver somniferum. It is typically used to treat mild to moderate degrees of pain. Greater benefit may occur when combined with paracetamol (acetaminophen) as codeine/paracetamol or a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin or ibuprofen.

4-Caffeoyl-1,5-quinide4-Caffeoyl-1,5-quinide (4-caffeoylquinic-1,5-lactone or 4-CQL) is found in roasted coffee beans. It is formed by lactonization of 4-O-caffeoylquinic acid during the roasting process. It is reported to possess opioid antagonist properties in mice. Referencesδ-opioid(DOR)κ-opioid(KOR)Nociceptin(NOP)OthersEnkephalinase inhibitors:AmastatinCandoxatrilD-PhenylalanineEcadotril (sinorphan)KelatorphanRacecadotril (acetorphan)RB-101RB-120RB-3007SelankSemaxSpinorphinThiorphanTynorphinUbenimex (bestatin)Propeptides:β-Li...

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