The globose nucleus is one of the

deep cerebellar nuclei There are four paired deep cerebellar nuclei embedded in the white matter centre of the cerebellum. The nuclei are the fastigial, globose, emboliform, and dentate nuclei. In lower mammals the emboliform nucleus appears to be continuous with t ...

. It is located medial to the

emboliform nucleus The emboliform nucleus is a deep cerebellar nucleus that lies immediately to the medial side of the dentate nucleus, partly covering its hilum. It is one of the four pairs of deep cerebellar nuclei, which are from lateral to medial: the dent ...

, and lateral to the

fastigial nucleus The fastigial nucleus (roof nucleus-1) is located in each cerebellar hemisphere. It is one of the four paired deep cerebellar nuclei of the cerebellum. It is made up of two sections: the rostral fastigial nucleus and the caudal fastigial nucle ...

. The ''globose nucleus'' and emboliform nucleus are known collectively as the interposed nuclei. The globose nucleus is part of a neural circuit giving rise to descending motor tracts involved in motor control of distal musculature of the upper and lower limbs.

Anatomy

Afferents

Purkinje cell Purkinje cells or Purkinje neurons, named for Czech physiologist Jan Evangelista Purkyně who identified them in 1837, are a unique type of prominent, large neuron located in the Cerebellum, cerebellar Cortex (anatomy), cortex of the brain. Wi ...

s of (the paravermal cortex of) the

spinocerebellum The anatomy of the cerebellum can be viewed at three levels. At the level of gross anatomy, the cerebellum consists of a tightly folded and crumpled layer of Cerebellar cortex, cortex, with white matter underneath, several deep nuclei embedded i ...

Anterior spinocerebellar tract The spinocerebellar tracts are nerve tracts originating in the spinal cord and terminating in the same side ( ipsilateral) of the cerebellum. The two main tracts are the dorsal spinocerebellar tract, and the ventral spinocerebellar tract. Both of ...

(via

restiform body The inferior cerebellar peduncle is formed by fibers of the restiform body that join with fibers from the much smaller juxtarestiform body. The inferior cerebellar peduncle is the smallest of the three cerebellar peduncles. The upper part of th ...

inferior cerebellar peduncle The inferior cerebellar peduncle is formed by fibers of the restiform body that join with fibers from the much smaller juxtarestiform body. The inferior cerebellar peduncle is the smallest of the three cerebellar peduncles. The upper part of t ...

)

Efferents

* Contralateral (magnocellular division of)

red nucleus The red nucleus or nucleus ruber is a structure in the rostral midbrain involved in motor coordination. The red nucleus is pale pink, which is believed to be due to the presence of iron in at least two different forms: hemoglobin and ferritin. ...

(via the

superior cerebellar peduncle In the human brain, the superior cerebellar peduncle (brachium conjunctivum) is one of the three paired cerebellar peduncles of bundled fibers that connect the cerebellum to the brainstem. The superior cerebellar peduncle connects to the midbrain. ...

). This is the major major efferent projection of the globose nucleus. The red nucleus in turn gives rise to the

rubrospinal tract The rubrospinal tract is one of the descending tracts of the spinal cord. It is a motor control pathway that originates in the red nucleus. It is a part of the lateral indirect extrapyramidal tract. The rubrospinal tract fibers are efferent ne ...

. * Ipsilateral ventral lateral nucleus of thalamus. The VL nucleus in turn projects to the

primary motor cortex The primary motor cortex ( Brodmann area 4) is a brain region that in humans is located in the dorsal portion of the frontal lobe. It is the primary region of the motor system and works in association with other motor areas including premotor c ...

and

premotor cortex The premotor cortex is an area of the motor cortex lying within the frontal lobe of the brain just anterior to the primary motor cortex. It occupies part of Brodmann's area 6. It has been studied mainly in primates, including monkeys and human ...

(which then give rise to the

lateral corticospinal tract Lateral is a geometric term of location which may also refer to: Biology and healthcare * Lateral (anatomy), a term of location meaning "towards the side" * Lateral cricoarytenoid muscle, an intrinsic muscle of the larynx * Lateral release ( ...

Cell biology

This nucleus contains primarily large and small multipolar neurons.

References

External links

* https://web.archive.org/web/20150621011739/http://www.mona.uwi.edu/fpas/courses/physiology/neurophysiology/Cerebellum.htm * https://web.archive.org/web/20080405060224/http://www.lib.mcg.edu/edu/eshuphysio/program/section8/8ch6/s8ch6_30.htm
NIF Search - Globose Nucleus
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