Zenarestat (FK-366; FR-74366) is an

aldose reductase inhibitor Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. Mechanism Their target, aldose reductase, is an enzyme that is normally present in many other parts of the body, and ca ...

. It was investigated as a treatment of

diabetic neuropathy Diabetic neuropathy includes various types of nerve damage associated with diabetes mellitus. The most common form, diabetic peripheral neuropathy, affects 30% of all diabetic patients. Studies suggests that cutaneous nerve branches, such as the s ...

and

cataract A cataract is a cloudy area in the lens (anatomy), lens of the eye that leads to a visual impairment, decrease in vision of the eye. Cataracts often develop slowly and can affect one or both eyes. Symptoms may include faded colours, blurry or ...

, but its development was terminated.

References

* M. Hashimoto et al., EP 218999; eidem, US 4734419 (1987, 1988 both to Fujisawa) * Inhibition kinetics and effect on sorbitol accumulation: S. Ao et al., Metabolism 40, 77 (1991) * Pharmacokinetics and metabolism in diabetic rats: Y. Tanaka et al., Drug Metab. Dispos. 21, 677 (1993) * M. Kanamaru et al., J. Clin. Pharmacol. 33, 1122 (1993). Abandoned drugs Aldose reductase inhibitors Orphan drugs {{gastrointestinal-drug-stub