ZSC may refer to:
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Zamalek SC
Zamalek Sporting Club (), commonly referred to as Zamalek, is an List of football clubs in Egypt, Egyptian Club based in Cairo, Egypt. The club is best known for its professional men's Association football, football team, which plays in the Egy ...
, an Egyptian sports club
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ZSC Lions
The Zürcher Schlittschuh Club Lions are a professional ice hockey team located in Zürich, Switzerland, playing in the National League (NL). Their home arena is the 12,000-seat Swiss Life Arena. The team was founded in 1930 and played at the ...
, a Swiss ice hockey club
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