''Yotsuba'' may refer to:
* ''
Yotsuba&!'', a Japanese manga by Kiyohiko Azuma
*
Yotsuba Koiwai, the title character from ''Yotsuba&!''
* Yotsuba, a character from the manga and anime ''
Sister Princess''
* Yotsuba Nakano, a character from the manga and anime ''
The Quintessential Quintuplets''
* Yotsuba Group,
the name of a group in the Japanese manga and anime ''Death Note''
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