is a Japanese
cell biologist specializing in
autophagy
Autophagy (or autophagocytosis; from the Greek language, Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-depe ...
, the process that cells use to destroy and recycle cellular components. Ohsumi is a professor at
Institute of Science Tokyo's Institute of Innovative Research.
[Yoshinori Ohsumi's ] He received the
Kyoto Prize
The is Japan's highest private award for lifetime achievement in the arts and sciences. It is given not only to those that are top representatives of their own respective fields, but to "those who have contributed significantly to the scientific, ...
for Basic Sciences in 2012, the 2016
Nobel Prize
The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...
in
Physiology or Medicine
The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute, Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single ...
, and the 2017
Breakthrough Prize in Life Sciences
for his discoveries of mechanisms for autophagy.
Biography

Ohsumi was born on February 9, 1945, in
Fukuoka
is the List of Japanese cities by population, sixth-largest city in Japan and the capital city of Fukuoka Prefecture, Japan. The city is built along the shores of Hakata Bay, and has been a center of international commerce since ancient times. ...
. He received a
B.Sci. in 1967 and a D.Sci. in 1974, both from the
University of Tokyo
The University of Tokyo (, abbreviated as in Japanese and UTokyo in English) is a public research university in Bunkyō, Tokyo, Japan. Founded in 1877 as the nation's first modern university by the merger of several pre-westernisation era ins ...
. In 1974–77 he was a
postdoctoral fellow at the
Rockefeller University
The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...
in New York City.
He returned to the University of Tokyo in 1977 as a
research associate
Research associates are researchers (scholars and professionals) that usually have an advanced degree beyond a Bachelor's degree such as a master's degree or a PhD.
In some universities/research institutes, such as Harvard/Harvard Medical Scho ...
; he was appointed Lecturer there in 1986, and promoted to Associate Professor in 1988. In 1996, he moved to the
National Institute for Basic Biology, Japan in
Okazaki City, where he was appointed as a professor. From 2004 to 2009, he was also professor at the
Graduate University for Advanced Studies in
Hayama. In 2009, he transitioned to a three-way appointment as an
emeritus professor
''Emeritus/Emerita'' () is an honorary title granted to someone who retires from a position of distinction, most commonly an academic faculty position, but is allowed to continue using the previous title, as in "professor emeritus".
In some c ...
at the National Institute for Basic Biology and at the
Graduate University for Advanced Studies, and a professorship at the Advanced Research Organization, Integrated Research Institute,
Tokyo Institute of Technology
The Tokyo Institute of Technology () was a public university in Meguro, Tokyo, Japan. It merged with Tokyo Medical and Dental University to form the Institute of Science Tokyo on 1 October 2024.
The Tokyo Institute of Technology was a De ...
(Tokyo Tech). After his retirement in 2014, he continued to serve as Professor at Institute of Innovative Research, Tokyo Institute of Technology. Currently, he is head of the Cell Biology Research Unit, Institute of Innovative Research, Tokyo Institute of Technology.
Christian de Duve
Christian René Marie Joseph, Viscount de Duve (2 October 1917 – 4 May 2013) was a Nobel Prize-winning Belgian cytologist and biochemist. He made serendipitous discoveries of two cell organelles, peroxisomes and lysosomes, for which he sh ...
coined the term
autophagy
Autophagy (or autophagocytosis; from the Greek language, Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-depe ...
in 1963 whereas Ohsumi began his work in 1988. Prior to that time, less than 20 papers per year were published on this subject.
During the 1990s, Ohsumi's group described the morphology of autophagy in yeast, and performed mutational screening on yeast cells that identified essential genes for cells to be capable of autophagy.
In 2016, he was awarded the
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...
"for his discoveries of mechanisms for
autophagy
Autophagy (or autophagocytosis; from the Greek language, Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-depe ...
".
He is the 25th Japanese person to be awarded a Nobel Prize.
Ohsumi's spouse Mariko, a Professor of
Teikyo University of Science, collaborated on his research. She is a co-author of many academic papers with him.
Recognition

Source:
*2005 – Fujihara Award, Fujihara Foundation of Science
*2006 –
Japan Academy Prize,
Japan Academy
The Japan Academy ( Japanese: 日本学士院, ''Nihon Gakushiin'') is an honorary organisation and science academy founded in 1879 to bring together leading Japanese scholars with distinguished records of scientific achievements. The Academy is ...
*2007 – Science Award,
*2008 –
Asahi Prize
The , established in 1929, is an award presented by the Japanese newspaper ''Asahi Shimbun'' and Asahi Shimbun Foundation to honor individuals and groups that have made outstanding accomplishments in the fields of arts and academics and have greatl ...
, ''
Asahi Shimbun
is a Japanese daily newspaper founded in 1879. It is one of the oldest newspapers in Japan and Asia, and is considered a newspaper of record for Japan.
The ''Asahi Shimbun'' is one of the five largest newspapers in Japan along with the ''Yom ...
''
*2012 –
Kyoto Prize in Basic Sciences
*2013 –
Thomson Reuters Citation Laureate
*2015 –
Gairdner Foundation International Award
*2015 –
International Prize for Biology
*2015 –
Keio Medical Science Prize
The Keio Medical Science Prize ( Japanese: 慶應医学賞) is a Japanese prize in medical sciences.
Introduction
The prize is awarded to scientists who made significant contributions to the field of medical sciences or life sciences. And these c ...
*2015 –
Person of Cultural Merit
*2015 –
Rosenstiel Award
*2016 –
Wiley Prize in Biomedical Sciences
*2016 –
Dr. Paul Janssen Award for Biomedical Research
*2016 –
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...
*2016 and 2017 –
Asian Scientist 100
The Asian Scientist 100 is an annually published list of 100 prize-winning Asian researchers, academicians, innovators and business leaders from across the Asia-Pacific region and a range of scientific disciplines. Recipients "must have received ...
, ''
Asian Scientist
''Asian Scientist'' is an English language science and technology magazine published in Singapore.
History and profile
''Asian Scientist'' was launched as a blog in March 2011 by Juliana Chan. The blog's popularity eventually led to a partnersh ...
''
*2017 –
Breakthrough Prize in Life Sciences
*2017 – Honorary doctorate from
Kyoto University
, or , is a National university, national research university in Kyoto, Japan. Founded in 1897, it is one of the former Imperial Universities and the second oldest university in Japan.
The university has ten undergraduate faculties, eighteen gra ...
, Japan
Yoshinori Ohsumi awarded Honorary Doctorate, delivers special lecture (13 July 2017) , 京都大學
/ref>
Selected publications
His original findings about autophagy in yeast cells:
*
Follow up with more research on yeast:
*
Others
*
*
*
*
*
*
*
*
*
*
*
See also
* List of Japanese Nobel laureates
* List of Nobel laureates affiliated with the University of Tokyo
References
External links
* inclkuding the Nobel Lecture December 7, 2016 ''Molecular Mechanisms of Autophagy in Yeast''
{{DEFAULTSORT:Ohsumi, Yoshinori
Japanese cell biologists
21st-century Japanese biologists
Nobel laureates in Physiology or Medicine
Academic staff of the University of Tokyo
Academic staff of Tokyo Institute of Technology
1945 births
Living people
People from Fukuoka
Scientists from Fukuoka
Kyoto laureates in Basic Sciences
University of Tokyo alumni
Persons of Cultural Merit
Members of the European Molecular Biology Organization
Japanese Nobel laureates
Recipients of the Order of Culture