YKL-05-099 is an experimental drug which acts as an inhibitor of the

salt-inducible kinase Salt-inducible kinases, also known as SIK enzymes, are a family of proteins found in most animal species. They are a type of serine-threonine kinase enzymes. They were originally isolated from the adrenal glands of rats fed with a high-salt diet. S ...

(SIK) enzymes. It has

antiinflammatory Anti-inflammatory is the property of a substance or treatment that reduces inflammation, fever or swelling. Anti-inflammatory drugs, also called anti-inflammatories, make up about half of analgesics. These drugs reduce pain by inhibiting mechani ...

effects and is used for research into the potential applications of salt-inducible kinase inhibitors in treating several conditions including

leukemia Leukemia ( also spelled leukaemia; pronounced ) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or '' ...

osteoporosis Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in Bone fracture, fracture risk. It is the most common reason f ...

and

obesity Obesity is a medical condition, considered by multiple organizations to be a disease, in which excess Adipose tissue, body fat has accumulated to such an extent that it can potentially have negative effects on health. People are classifi ...

References

{{reflist Experimental drugs Chlorobenzene derivatives Pyrimidopyrimidines Methoxy compounds Disubstituted pyridines Piperidines Protein kinase inhibitors