XLR-12 is an
indole
Indole is an organic compound with the formula . Indole is classified as an aromatic heterocycle. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indoles are derivatives of indole ...
-based
synthetic cannabinoid
Synthetic cannabinoids, or neocannabinoids, are a class of designer drug molecules that Binding affinity, bind to the same receptors to which cannabinoids (Tetrahydrocannabinol, THC, Cannabidiol, CBD and many others) in cannabis plants attach. Th ...
drug that was invented by
Abbott Laboratories
Abbott Laboratories is an American multinational medical devices and health care company with headquarters in Abbott Park, Illinois, in the United States. The company was founded by Chicago physician Wallace Calvin Abbott in 1888 to formulate k ...
in 2006.
It is an analogue of
XLR-11 where the 5-fluoropentyl chain has been replaced with a 4,4,4-trifluorobutyl chain. XLR-12 is relatively highly selective for the CB
2 receptor, with a K
i of 0.09 nM and 167x selectivity over the related CB
1 receptor, however it still retains appreciable affinity for CB
1 with a K
i of 15 nM.
Legal status
XLR-12 is illegal in Hungary and Japan.
See also
*
UR-144
*
FUB-144
*
JTE 7-31
References
Cannabinoids
Designer drugs
Tetramethylcyclopropanoylindoles
{{cannabinoid-stub