The Working formulation is an obsolete classification of
non-Hodgkin lymphoma
Non-Hodgkin lymphoma (NHL), also known as non-Hodgkin's lymphoma, is a group of blood cancers that includes all types of lymphomas except Hodgkin lymphomas. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and tire ...
s, first proposed in 1982.
It has since been replaced by other
lymphoma
Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). In current usage the name usually refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enl ...
classifications, the latest published by the
WHO in 2016
but is still used by cancer agencies for compilation of lymphoma statistics.
Low Grade
*Malignant lymphoma, small lymphocytic (
chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). Early on, there are typically no symptoms. Later, non-painful lymph node swelling, feeling tired, fever, n ...
)
*Malignant lymphoma,
follicular, predominantly small cleaved cell
*Malignant lymphoma,
follicular, mixed (small cleaved and
large cell
Large cell is a term used in oncology. It does not refer to a particular type of cell; rather it refers to cells that are larger than would be normally expected for that type. It is frequently used when describing lymphoma and lung cancer.
It was ...
)
Intermediate grade
*Malignant lymphoma,
follicular, predominantly large cell
*Malignant lymphoma, diffuse, small cleaved cell
*Malignant lymphoma, diffuse, mixed small and large cell
*Malignant lymphoma, diffuse, large cell
High grade
*Malignant lymphoma, large cell, immunoblastic
*Malignant lymphoma,
lymphoblastic
*Malignant lymphoma, small noncleaved cells (
Burkitt lymphoma
Burkitt lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa. ...
)
Miscellaneous
*Composite
*
Mycosis fungoides
Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma. It generally affects the skin, but may progress internally over time. Symptoms include rash, tumors, skin lesions ...
*
Histiocytic
A histiocyte is a vertebrate cell that is part of the mononuclear phagocyte system (also known as the reticuloendothelial system or lymphoreticular system). The mononuclear phagocytic system is part of the organism's immune system. The histiocy ...
*
Extramedullary plasmacytoma
Plasmacytoma is a plasma cell dyscrasia in which a plasma cell tumour grows within soft tissue or within the axial skeleton.
The International Myeloma Working Group lists three types: solitary plasmacytoma of bone (SPB); extramedullary plasmac ...
*Unclassifiable
References
{{Lymphoid malignancy
Lymphoma