William Jephson may refer to:
* Sir
William Jephson (died 1615), MP for Hampshire
*
William Jephson (died 1658), MP for Stockbridge and Cork
*
William Jephson (died 1691), MP for East Grinstead and Wycombe
*
William Jephson (died 1698), MP for Mallow
*
William Jephson (died 1716), MP for
Mallow
*
William Jephson (died 1779), MP for
Mallow
*
William Jephson (priest) (died 1720), dean of Lismore
*
William Jephson (cricketer) (1873–1956), English cricketer
{{hndis, Jephson, William