Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''WNK3''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
WNK3 is a protein belonging to the 'with no lysine' family of
serine-threonine protein kinases. These family members lack the catalytic
lysine
Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins. Lysine contains an α-amino group (which is in the protonated form when the lysine is dissolved in water at physiological pH), an α-carboxylic acid group ( ...
in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular
Ca2+ transport pathway, and it plays a role in the increase of cell survival in a
caspase 3
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the ''CASP3'' gene. ''CASP3'' orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are als ...
dependent pathway.
References
Further reading
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EC 2.7.11
{{gene-X-stub