Vitamin D3 24-hydroxylase
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Vitamin D3 24-hydroxylase (, ''
CYP24A1 Cytochrome P450 family 24 subfamily A member 1 (abbreviated CYP24A1) is a member of the cytochrome P450 superfamily of enzymes encoded by the ''CYP24A1'' gene. It is a mitochondrial monooxygenase which catalyzes reactions including 24-hydroxylatio ...
'') is an
enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ...
''calcitriol,NADPH:oxygen oxidoreductase (24-hydroxylating)''. This enzyme catalyses the following
chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: (1) calcitriol + NADPH + H+ + O2 \rightleftharpoons calcitetrol + NADP+ + H2O : (2) calcidiol + NADPH + H+ + O2 \rightleftharpoons secalciferol + NADP+ + H2O Vitamin D3 24-hydroxylase is a
heme Heme (American English), or haem (Commonwealth English, both pronounced /Help:IPA/English, hi:m/ ), is a ring-shaped iron-containing molecule that commonly serves as a Ligand (biochemistry), ligand of various proteins, more notably as a Prostheti ...
-
thiol In organic chemistry, a thiol (; ), or thiol derivative, is any organosulfur compound of the form , where R represents an alkyl or other organic substituent. The functional group itself is referred to as either a thiol group or a sulfhydryl grou ...
ate enzyme (P-450).


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* {{Portal bar, Biology, border=no EC 1.14.13