The ventral nerve cord is a major structure of the

invertebrate Invertebrates are animals that neither develop nor retain a vertebral column (commonly known as a ''spine'' or ''backbone''), which evolved from the notochord. It is a paraphyletic grouping including all animals excluding the chordata, chordate s ...

central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain, spinal cord and retina. The CNS is so named because the brain integrates the received information and coordinates and influences the activity o ...

. It is the functional equivalent of the

vertebrate Vertebrates () are animals with a vertebral column (backbone or spine), and a cranium, or skull. The vertebral column surrounds and protects the spinal cord, while the cranium protects the brain. The vertebrates make up the subphylum Vertebra ...

spinal cord The spinal cord is a long, thin, tubular structure made up of nervous tissue that extends from the medulla oblongata in the lower brainstem to the lumbar region of the vertebral column (backbone) of vertebrate animals. The center of the spinal c ...

. The ventral nerve cord coordinates neural signaling from the brain to the body and vice versa, integrating sensory input and locomotor output. Because arthropods have an

open circulatory system In vertebrates, the circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the body. It includes the cardiovascular system, or vascular system, that consists of the heart a ...

, decapitated insects can still walk, groom, and mate — illustrating that the circuitry of the ventral nerve cord is sufficient to perform complex motor programs without brain input.

Structure

The ventral nerve cord runs down the

ventral Standard anatomical terms of location are used to describe unambiguously the anatomy of humans and other animals. The terms, typically derived from Latin or Greek roots, describe something in its standard anatomical position. This position prov ...

("belly", as opposed to back) plane of the organism. It is made of nervous tissue and is connected to the brain. Ventral nerve cord neurons are physically organized into neuromeres that process signals for each body segment. Anterior neuromeres control the anterior body segments, such as the forelegs, and more posterior neuromeres control the posterior body segments, such as the hind legs. Neuromeres are connected longitudinally, anterior to posterior, by fibrous nerve tracts called connectives. Pairs of hemisegments, corresponding to the left and right side of the ventral nerve cord, are connected horizontally by fibrous tracts called commissures. In the small worm Meara stichopi there is a pair of dorsal nerve cords instead.

Function

Like the vertebrate spinal cord, the function of the ventral nerve cord is to integrate and transmit nerve signals. It contains ascending and descending neurons that relay information to and from the brain,

motor neuron A motor neuron (or motoneuron), also known as efferent neuron is a neuron whose cell body is located in the motor cortex, brainstem or the spinal cord, and whose axon (fiber) projects to the spinal cord or outside of the spinal cord to directly o ...

s that project into the body and synapse onto muscles,

axon An axon (from Greek ἄξων ''áxōn'', axis) or nerve fiber (or nerve fibre: see American and British English spelling differences#-re, -er, spelling differences) is a long, slender cellular extensions, projection of a nerve cell, or neuron, ...

s from

sensory neuron Sensory neurons, also known as afferent neurons, are neurons in the nervous system, that convert a specific type of stimulus, via their receptors, into action potentials or graded receptor potentials. This process is called sensory transduc ...

s that receive information from the body and environment, and

interneuron Interneurons (also called internuncial neurons, association neurons, connector neurons, or intermediate neurons) are neurons that are not specifically motor neurons or sensory neurons. Interneurons are the central nodes of neural circuits, enab ...

s that coordinate circuitry of all of these neurons. In addition to spiking

neuron A neuron (American English), neurone (British English), or nerve cell, is an membrane potential#Cell excitability, excitable cell (biology), cell that fires electric signals called action potentials across a neural network (biology), neural net ...

s which transmit

action potential An action potential (also known as a nerve impulse or "spike" when in a neuron) is a series of quick changes in voltage across a cell membrane. An action potential occurs when the membrane potential of a specific Cell (biology), cell rapidly ri ...

s, some neural information is transmitted via non-spiking interneurons. These interneurons filter, amplify, and integrate internal and external neural signals to guide and control movement and behavior.

Evolution

Ventral nerve cords are found in some

phyla Phyla, the plural of ''phylum'', may refer to: * Phylum, a biological taxon between Kingdom and Class * by analogy, in linguistics, a large division of possibly related languages, or a major language family which is not subordinate to another Phy ...

of the

bilaterian Bilateria () is a large clade of animals characterised by bilateral symmetry during embryonic development. This means their body plans are laid around a longitudinal axis with a front (or "head") and a rear (or "tail") end, as well as a left–r ...

s, particularly within the

nematode The nematodes ( or ; ; ), roundworms or eelworms constitute the phylum Nematoda. Species in the phylum inhabit a broad range of environments. Most species are free-living, feeding on microorganisms, but many are parasitic. Parasitic worms (h ...

annelid The annelids (), also known as the segmented worms, are animals that comprise the phylum Annelida (; ). The phylum contains over 22,000 extant species, including ragworms, earthworms, and leeches. The species exist in and have adapted to vario ...

s and the

arthropod Arthropods ( ) are invertebrates in the phylum Arthropoda. They possess an arthropod exoskeleton, exoskeleton with a cuticle made of chitin, often Mineralization (biology), mineralised with calcium carbonate, a body with differentiated (Metam ...

s. Ventral nerve cords are well-studied within

insect Insects (from Latin ') are Hexapoda, hexapod invertebrates of the class (biology), class Insecta. They are the largest group within the arthropod phylum. Insects have a chitinous exoskeleton, a three-part body (Insect morphology#Head, head, ...

s, have been described in over 300 species covering all the major orders, and have remarkable morphological diversity. Many insects have a rope-ladder-like ventral nervous cord, composed of physically separated

segmental ganglia The segmental ganglia (singular: s. ganglion) are ganglia of the annelid and arthropod central nervous system that lie in the segmented ventral nerve cord The ventral nerve cord is a major structure of the invertebrate central nervous syste ...

. In contrast, in ''Drosophila'', the thoracic and abdominal neuromeres are contiguous and the whole ventral nerve cord is considered to be one ganglion. The presumed common ancestral structure is rarely observed; instead the ventral nerve cords of most insects show extensive modification as well as

convergence Convergence may refer to: Arts and media Literature *''Convergence'' (book series), edited by Ruth Nanda Anshen *Convergence (comics), "Convergence" (comics), two separate story lines published by DC Comics: **A four-part crossover storyline that ...

. Modifications include shifts in

neuromere Neuromeres are distinct groups of neural crest cells, forming segments in the neural tube of the early embryonic development of the brain. There are three classes of neuromeres in the central nervous system – prosomeres (for the prosencephalon ...

positions, their fusion to form composite ganglia, and, potentially, their separation to revert to individual ganglia. In organisms with fused neuromeres, the connectives are still there but are very reduced in length.

Development

The insect ventral nerve cord develops according to a body plan based on a segmental set of 30 paired and one unpaired

neuroblast In vertebrates, a neuroblast or primitive nerve cell is a postmitotic cell that does not divide further, and which will develop into a neuron after a migration phase. In invertebrates such as ''Drosophila,'' neuroblasts are neural progenitor cells ...

s. A neuroblast can be uniquely identified based on its position in the array, its pattern of molecular expression, and the suite of early neurons that it produces. Each neuroblast gives rise to two hemilineages: an "A" hemilineage characterized by active Notch signalling, and a "B" hemilineage characterized by an absence of active Notch signalling. Research in the fruit fly '' D. melanogaster'' suggests that all neurons of a given hemilineage release the same primary

neurotransmitter A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a Chemical synapse, synapse. The cell receiving the signal, or target cell, may be another neuron, but could also be a gland or muscle cell. Neurotra ...

. Engrailed is a

transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription (genetics), transcription of genetics, genetic information from DNA to messenger RNA, by binding t ...

that helps regulate the gene ''frazzled'' in order to separate

s during embryonic development. The segregation of neuroblasts is essential for the formation and development of the ventral nerve cord.

References

External links