Velneperit (S-2367) is a drug developed by Shionogi, which acts as a potent and selective

antagonist An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ...

for the Neuropeptide Y receptor Y₅. It has anorectic effects and was developed as a possible treatment for obesity, but was discontinued from further development after disappointing results in Phase II clinical trials. However it was still considered a successful proof of concept of the potential of Y₅ receptor antagonists as possible anti-obesity agents in future.

References

Neuropeptide Y antagonists Tert-butyl compounds Sulfonamides Trifluoromethyl compounds Carboxamides {{nervous-system-drug-stub