Vacuolar segregation protein 7 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in yeast is encoded by the ''VAC7''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. VAC7 is a component of the PI(3,5)P2 regulatory complex, composed of ATG18,

FIG4 Polyphosphoinositide phosphatase also known as phosphatidylinositol 3,5-bisphosphate 5-phosphatase or SAC domain-containing protein 3 (Sac3) is an enzyme that in humans is encoded by the ''FIG4'' gene. Fig4 is an abbreviation for Factor-Induced G ...

, FAB1,

VAC14 Protein VAC14 homolog, also known as ArPIKfyve (Associated Regulator of PIKfyve), is a protein that in humans is encoded by the ''VAC14'' gene. Function The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membran ...

and VAC7.

Function

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of

phosphatidylinositol 3,5-bisphosphate Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is one of the seven phosphoinositides found in eukaryotic cell membranes. In quiescent cells, the PtdIns(3,5)P2 levels, typically quantified by HPLC, are the lowest amongst the constitutively ...

(PtdIns(3,5)P2). VAC7 activates FAB1 kinase for example during hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of

and

. VAC7 is directly involved in

vacuolar A vacuole () is a membrane-bound organelle which is present in plant and fungal cells and some protist, animal, and bacterial cells. Vacuoles are essentially enclosed compartments which are filled with water containing inorganic and organic mol ...

membrane scission and is required for normal vacuole acidification, inheritance and morphology.

UniProt UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived fro ...

References

Saccharomyces cerevisiae genes {{protein-stub