VPS29 is a human
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
coding for the vacuolar protein sorting
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
Vps29, a component of the
retromer
Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the ''trans''-Golgi network (TGN) and directly back to the plasma membrane. Mutations in retromer and its associated pro ...
complex.
Yeast homolog
The homologous protein (one that performs the same function) in yeast is Vacuolar protein sorting 29 homolog (S. cerevisiae).
Function
VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of
vacuolar hydrolase
In biochemistry, hydrolases constitute a class of enzymes that commonly function as biochemical catalysts that use water to break a chemical bond:
:\ce \quad \xrightarrowtext\quad \ce
This typically results in dividing a larger molecule into s ...
s.
The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the
retromer
Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the ''trans''-Golgi network (TGN) and directly back to the plasma membrane. Mutations in retromer and its associated pro ...
complex, which is involved in retrograde transport of proteins from endosomes to the
trans-Golgi network
The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles insi ...
. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment.
variants encoding different isoforms, and usage of multiple
polyadenylation
Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In euka ...
sites have been found for this gene.
References
Further reading
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