The Upjohn Company was an American pharmaceutical manufacturing firm (est. 1886) in

Hastings, Michigan Hastings ( ) is a city in the U.S. state of Michigan. It is the county seat of Barry County, as well as the county's only city. The population was 7,514 at the 2020 census. The city borders Hastings Charter Township on the north, east, and ...

, by Dr. William E. Upjohn, an 1875 graduate of the

University of Michigan The University of Michigan (U-M, U of M, or Michigan) is a public university, public research university in Ann Arbor, Michigan, United States. Founded in 1817, it is the oldest institution of higher education in the state. The University of Mi ...

medical school. The company was originally formed to make ''friable pills'', specifically designed to crush easily, and thus be easier for patients to digest. Upjohn initially marketed the pills to doctors by sending them a wooden plank along with a rival’s pill and one of Upjohn’s, with instructions to try to hammer the pills into the plank.

History

Upjohn developed a process for the large scale production of

cortisone Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug. Cortisol is converted by the action of the enzyme corticosteroid 11-beta-dehydrogenase ...

. The oxygen atom group must be in position 11 for this steroid to function. There are, however, no known natural starting materials with an oxo-group in position 11. The only method for preparing cortisone prior to 1952 was a lengthy synthesis, starting from cholic acid isolated from bile. In 1952, two Upjohn biochemists, Dury Peterson and Herb Murray, announced that they had invented a new method by fermenting the steroid

progesterone Progesterone (; P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the ma ...

with a common mold of the genus Rhizopus. Over the next several years, a group of chemists headed by John Hogg developed a process for preparing cortisone from the soybean sterol

stigmasterol Stigmasterol – a plant sterol (''phytosterol'') – is among the most abundant of plant sterols, having a major function to maintain the structure and physiology of cell membranes. In the European Union, it is a food additive listed with E nu ...

. The microbiological oxygenation invented by Peterson and Murry is a key step in this process. Subsequently, Upjohn (together with

Pharmacia Pharmacia was a pharmaceutical and biotechnological company in Sweden that merged with the American pharmaceutical company Upjohn in 1995. History Pharmacia company was founded in 1911 in Stockholm, Sweden by pharmacist Gustav Felix Grönfel ...

) biochemically converted cortisone into the more potent

steroid A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes t ...

prednisone Prednisone is a glucocorticoid medication mostly used to immunosuppressive drug, suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also used to treat high blood calcium ...

via bacterial fermentation. In chemical research, the company is known for the development of the Upjohn dihydroxylation by V. VanRheenen, R. C. Kelly, and D. Y. Cha in 1976. Upjohn's best known drugs before its acquisition by Pfizer were

Xanax Alprazolam, sold under the brand name Xanax among others, is a fast-acting, potent tranquilizer of moderate duration within the triazolobenzodiazepine group of chemicals called benzodiazepines. Alprazolam is most commonly prescribed in the ...

, Halcion, Motrin, Lincocin, and Rogaine. In 1995, Upjohn merged with

AB to form

Pharmacia & Upjohn Pharmacia & Upjohn was a global pharmaceutical company formed by the merger of Sweden-based Pharmacia AB and the American company Upjohn in 1995. Today the remainder of the company is owned by Pfizer. In 1997, Pharmacia & Upjohn sold several b ...

. The company was owned by

Pfizer Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...

from 2002 until 2020. In 2015, Pfizer resurrected the Upjohn brand name for a division which manufactures and licenses drugs with patents that have expired. Pfizer planned to divest itself of this business in 2020. In July 2019, Pfizer announced plans to merge Upjohn with

Mylan Mylan N.V. was a global generic and specialty pharmaceuticals company. In November 2020, Mylan merged with Upjohn, Pfizer's off-patent medicine division, to form Viatris. Previously, the company was domiciled in the Netherlands, with principa ...

. The merger was expected to close in the first half of 2020, was delayed due to the

COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began with an disease outbreak, outbreak of COVID-19 in Wuhan, China, in December ...

, and finally completed in November 2020. The resultant entity was named Viatris.

References

External links

Memories of The Upjohn Company
* {{Authority control 1886 establishments in Michigan 1995 disestablishments in Michigan 1995 mergers and acquisitions Companies based in Kalamazoo, Michigan Pharmaceutical companies established in 1886 Pharmaceutical companies disestablished in 1995 Defunct pharmaceutical companies of the United States Pfizer Life sciences industry Companies formerly listed on the New York Stock Exchange

History

See also

References

Further reading

External links