Umeclidinium bromide, sold under the brand name Incruse Ellipta among others, is a long-acting

muscarinic antagonist A muscarinic acetylcholine receptor antagonist, also simply known as a muscarinic antagonist or as an antimuscarinic agent, is a type of anticholinergic drug that blocks the activity of the muscarinic acetylcholine receptors (mAChRs). The muscarin ...

approved for the maintenance treatment of

chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by chronic respiratory symptoms and airflow limitation. GOLD defines COPD as a heterogeneous lung condition characterized by chronic respiratory s ...

(COPD). It is also approved for this indication in combination with

vilanterol Vilanterol is an ultra-long-acting β2-adrenoceptor agonist which was approved in May 2013 in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of chronic obstructive pulmonary disease (COPD). T ...

(as umeclidinium bromide/vilanterol), and also as a triple-therapy combination as

fluticasone furoate/umeclidinium bromide/vilanterol Fluticasone furoate/umeclidinium bromide/vilanterol, sold under the brand name Trelegy Ellipta among others, is a fixed-dose combination inhaled medication that is used for the maintenance treatment of chronic obstructive pulmonary disease (COP ...

. It is on the

World Health Organization's List of Essential Medicines The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health s ...

. In 2020, it was the 245th most commonly prescribed medication in the United States, with more than 1million prescriptions.

References

Bromides Drugs acting on the respiratory system Drugs developed by GSK plc Muscarinic antagonists Quaternary ammonium compounds Quinuclidines Bronchodilators {{respiratory-system-drug-stub