UV radiation resistance-associated gene protein is a
protein that in humans is encoded by the ''UVRAG''
gene.
This gene complements the
ultraviolet sensitivity of
xeroderma pigmentosum group C cells and encodes a protein with a
C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting
autophagy
Autophagy (or autophagocytosis; from the Ancient Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent re ...
and suppressing the proliferation and tumorigenicity of human colon cancer cells.
Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with
colon cancer
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel mo ...
.
References
Further reading
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